Confirmation of ofloxacin precipitation in corneal deposits by microbore liquid chromatography-quadrupole time-of-flight tandem mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 785, Issue 1, 2003, Pages 193-196

  Sinnaeve, Bart A ^a   Decaestecker, Tineke N ^a   Claerhout, Ilse J ^b   Kestelyn, Philippe ^b   Remon, Jean Paul ^a   Van Bocxlaer, Jan F ^a  

^a GHENT UNIVERSITY   (Belgium)

^b GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

Corneal precipitate; Ofloxacin

Indexed keywords

DISEASES; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRECIPITATION (CHEMICAL);

CORNEAL SCRAPPINGS;

CHROMATOGRAPHIC ANALYSIS;

OFLOXACIN;

ARTICLE; CASE REPORT; CORNEA; DRUG DETERMINATION; HUMAN; HUMAN TISSUE; LIQUID CHROMATOGRAPHY; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; VERNAL CONJUNCTIVITIS;

ANTI-INFECTIVE AGENTS; CHILD; CHROMATOGRAPHY, LIQUID; CORNEA; HUMANS; KERATOCONJUNCTIVITIS; MALE; MASS SPECTROMETRY; OFLOXACIN; PRECIPITATION;

EID: 0037465104     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1570-0232(02)00854-1     Document Type: Article

References (4)

1. Konishi M., Yamada M., Mashima Y. Corneal ulcer associated with deposits of norfloxacin. Am. J. Opthalmol. 125:1998;256.
2. Castillo A., DelCastillo J.M.B., Toledano N., DiazValle D., Sayagues O., GarciaSanchez J. Deposits of topical norfloxacin in the treatment of bacterial keratitis. Cornea. 16:1997;420.
3. Eiferman R.A., Snyder J.P., Nordquist R.E. Ciprofloxacin microprecipitates and macroprecipitates in the human corneal epithelium. J. Cataract Refract. Surg. 27:2001;1701.
4. Firestone B.A., Dickason M.A., Tran T. Solubility characteristics of three fluoroquinolone ophthalmic solutions in an in vitro tear model. Int. J. Pharm. 164:1998;119.