Pyrimidine to guanine PDE inhibitors: Determination of chemical course via structure elucidation

Tetrahedron Letters

Volumn 44, Issue 13, 2003, Pages 2717-2720

  Gala, Dinesh ^a   DiBenedetto, Donald J ^a   Kugleman, Max ^a   Puar, Mohindar S ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE DERIVATIVE; PHOSPHODIESTERASE INHIBITOR; PYRIMIDINE DERIVATIVE;

ARTICLE; DRUG SYNTHESIS; HYDROGEN BOND; STRUCTURE ANALYSIS; SYNTHESIS;

EID: 0037463736     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(03)00340-X     Document Type: Article

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6. NMR work on 14 and 16 implies that the lack of reaction is not due to the existence of any ring strained in 15. In addition, during the reduction of the nitro group to amine, no appreciable dehalogenation resulted.
7. 3 method did not melt past 275°C.
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