Epimerization at carbon-5′ of (5′R)-[5′-2H]adenosylcobalamin by ribonucleoside triphosphate reductase: Cysteine 408-independent cleavage of the Co-C5′ bond

Biochemistry

Volumn 42, Issue 15, 2003, Pages 4578-4584

  Chen, Dawei ^a   Abend, Andreas ^a   Stubbe, JoAnne ^b   Frey, Perry A ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON; CATALYST ACTIVITY; CHEMICAL BONDS; RATE CONSTANTS; REDUCTION; SOLVENTS; STEREOCHEMISTRY;

EPIMERIZATION;

BIOCHEMISTRY;

CYANOCOBALAMIN; DEOXYGUANOSINE TRIPHOSPHATE; DEUTERIUM; MUTANT PROTEIN; RIBONUCLEOSIDE DERIVATIVE; RIBONUCLEOSIDE TRIPHOSPHATE REDUCTASE; THIOL GROUP; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; CATALYSIS; CHEMICAL BOND; CHEMICAL REACTION; ENZYME DEGRADATION; EPIMERIZATION; PRIORITY JOURNAL; PROTEIN VARIANT; PROTON TRANSPORT; STEREOCHEMISTRY; WILD TYPE;

COBALT; OXIDOREDUCTASES; PROTEIN BINDING; VITAMIN B 12;

LACTOBACILLUS LEICHMANNII;

EID: 0037461322     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi030018x     Document Type: Article

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