Revisiting monomeric HIV-1 protease: Characterization and redesign for improved properties

Journal of Biological Chemistry

Volumn 278, Issue 8, 2003, Pages 6085-6092

  Louis, John M ^a   Ishima, Rieko ^b   Nesheiwat, Issa ^a   Pannell, Lewis K ^a   Lynch, Shannon M ^a   Torchia, Dennis A ^b   Gronenborn, Angela M ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIMERIZATION; MONOMERS; PROTEINS; VIRUSES;

DIMER STABILITY;

BIOCHEMISTRY;

ARGININE; ASPARTIC ACID; DISULFIDE; POLYPEPTIDE; PROTEINASE; CYSTEINE; RECOMBINANT PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; DIMERIZATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME STABILITY; HUMAN IMMUNODEFICIENCY VIRUS 1; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN INTERACTION; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; CHEMICAL STRUCTURE; CHEMISTRY; GENETIC VARIABILITY; KINETICS; METABOLISM; MOLECULAR GENETICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARGININE; ASPARTIC ACID; CYSTEINE; DIMERIZATION; DISULFIDES; ENZYME STABILITY; HIV PROTEASE; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; PROTEIN FOLDING; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; VARIATION (GENETICS);

EID: 0037458740     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M209726200     Document Type: Article

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