K-antigen-specific, but not O-antigen-specific natural human serum antibodies promote phagocytosis of Klebsiella pneumoniae

FEMS Immunology and Medical Microbiology

Volumn 35, Issue 2, 2003, Pages 93-98

  Lepper, Philipp M ^a   Möricke, Angelika ^a   Held, Thomas K ^b   Schneider, E Marion ^a   Trautmann, Matthias ^a,c  

^a UNIVERSITY HOSPITAL ULM   (Germany)

^b HUMBOLDT UNIVERSITY   (Germany)

^c KATHARINENHOSPITAL   (Germany)

Author keywords

Antibody; IgG; IgM; Innate immunity; Klebsiella; Phagocytosis

Indexed keywords

ANTIGEN; HYPERIMMUNE GLOBULIN; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; POLYSACCHARIDE;

ANTIBODY BLOOD LEVEL; ANTIGEN SPECIFICITY; ARTICLE; BACTERIAL VIRULENCE; BACTERICIDAL ACTIVITY; CELL COUNT; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENCAPSULATION; HUMAN; KLEBSIELLA PNEUMONIAE; NEUTROPHIL; NONHUMAN; NORMAL HUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; SEPSIS;

EID: 0037456634     PISSN: 09288244     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-8244(02)00459-5     Document Type: Article

References (28)

1. Berendt R.F., Knutsen G.L., Powanda M.C. Nonhuman primate model for the study of respiratory Klebsiella pneumoniae infection. Infect. Immun. 22:1978;275-281.
2. Carpenter J.L. Klebsiella pulmonary infections: occurrence at one medical center and review. Rev. Infect. Dis. 12:1990;672-682.
3. Cryz S.J., Mortimer P.M., et al. Seroepidemiologic of Klebsiella bacteremic isolates and implications for vaccine development. J. Clin. Microbiol. 23:1986;687-690.
4. de la Torre M.G., Romero-Vivas J., et al. Klebsiella bacteremia: an analysis of 100 episodes. Rev. Infect. Dis. 7:1985;143-150.
5. Donta S.T., Peduzzi P., et al. Immunoprophylaxis against Klebsiella and Pseudomonas infections. J. Infect. Dis. 174:1996;537-543.
6. Fung C.P., Hu B.S., et al. A 5-year study of the seroepidemiology of Klebsiella pneumoniae: high prevalence of capsular serotype K1 in Taiwan and implications for vaccine efficacy. J. Infect. Dis. 181:2000;2075-2079.
7. Glanz, S.A. and Slinker, B.K. (1990) Primer of Applied Regression and Analysis of Variance. MacGraw-Hill, New York.
8. Hansen D.S., Mestre F., et al. Klebsiella pneumoniae lipopolysaccharide O typing: revision of prototype strains and O-group distribution among clinical isolates from different sources and countries. J. Clin. Microbiol. 37:1999;56-62.
9. Held T.K., Jendrike N.J., et al. Binding to and opsonophagocytic activity of O-antigen specific monoclonal antibodies against encapsulated and nonencapsulated Klebsiella pneumoniae serotype O1 strains. Infect. Immun. 68:2000;2402-2409.
10. Held T.K., Trautmann M., et al. Monoclonal antibodies against Klebsiella capsular polysaccharide reduces severity and hematogenic spread of experimental Klebsiella pneumoniae pneumonia. Infect. Immun. 60:1992;1771-1778.
11. Jong G.M., Hsiue T.R., et al. Rapidly fatal outcome of bacteremic Klebsiella pneumoniae pneumonia in alcoholics. Chest. 107:1995;214-217.
12. Mandine E., Salles E.F., et al. Murine monoclonal antibodies to Klebsiella pneumoniae protect against lethal endotoxinemia and experimental infection with capsulated Klebsiella pneumoniae. Infect. Immun. 58:1990;2828-2833.
13. Meno Y., Amano K. Morphological evidence for penetration of anti-O antibodies through the capsule of Klebsiella pneumoniae. Infect. Immun. 58:1990;1421-1428.
14. Pollack M. Significance of circulating capsular antigen in Klebsiella infections. Infect. Immun. 13:1976;1543-1548.
15. Rukavina T., Ticac B., et al. Protective effect of antilipopolysaccharide monoclonal antibodies in experimental Klebsiella infection. Infect. Immun. 65:1997;1754-1760.
16. Tomas J.M., Camprubi S., et al. Surface exposure of O1 serotype lipopolysaccharide in Klebsiella pneumoniae strains expressing different K antigens. Infect. Immun. 59:1991;2006-2011.
17. Trautmann M., Cross A.S., et al. Evaluation of a competitive ELISA method for the determination of Klebsiella O antigens. J. Med. Microbiol. 44:1996;44-51.
18. Trautmann M., Cryz S.J., et al. A murine monoclonal antibody against Klebsiella capsular polysaccharide is opsonic in vitro and protects against experimental Klebsiella pneumoniae infection. Microb. Pathogen. 5:1988;177-187.
19. Trautmann M., Ghandchi A., et al. An enzyme-linked immunosorbent assay for the detection of soluble Klebsiella pneumoniae capsular polysaccharide. J. Microb. Methods. 13:1991;305-313.
20. Trautmann M., Held T.K., et al. Bacterial lipopolysaccharide-specific antibodies in commercial human immunoglobulin preparations: superior antibody content of an IgM-enriched product. Clin. Exp. Immunol. 111:1998;81-90.
21. Trautmann M., Ruhnke M., et al. O-antigen seroepidemiology of Klebsiella clinical isolates and implications for immunoprophylaxis of Klebsiella infections. Clin. Diagn. Lab. Immunol. 4:1997;550-555.
22. Trautmann M., Vogt K., et al. A murine monoclonal antibody defines a unique epitope shared by Klebsiella lipopolysaccharides. Infect. Immun. 62:1994;1282-1288.
23. Cortes G., Borrell N., et al. Molecular analysis of the contribution of the capsular polysaccharide and the lipopolysaccharide O side chain to the virulence of Klebsiella pneumoniae in a murine model of pneumonia. Infect. Immun. 70:2002;2583-2590.
24. Cryz S.J., Cross A.S., et al. Activity of intravenous immune globulins against Klebsiella. J. Lab. Clin. Med. 108:1986;182-189.
25. Alberti S., Alvarez D., et al. Analysis of complement C3 deposition and degradation on Klebsiella pneumoniae. Infect. Immun. 64:1996;4726-4732.
26. Tomas J.M., Benedi V.J., et al. Role of capsule and O antigen in resistance of Klebsiella pneumoniae to serum bactericidal activity. Infect. Immun. 54:1986;85-89.
27. Alvarez D., Merino S., et al. Capsular polysaccharide is a major complement resistance factor in lipopolysaccharide O side chain-deficient Klebsiella pneumoniae clinical isolates. Infect. Immun. 68:2000;953-955.
28. Lepper P.M., Held T.K., et al. Clinical implications of antibiotic induced endotoxin release in septic shock. Intensive Care Med. 28:2002;824-833.