Scale-up in the 4th dimension in the field of granulation and drying or how to avoid classical scale-up

Powder Technology

Volumn 130, Issue 1-3, 2003, Pages 225-230

  Leuenberger, Hans ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Batch versus continuous process; Glatt Multicell a quasi continuous production line of granules; Just in time production; Lights out operation; Reduction of time to market; Scale up

Indexed keywords

DRYING; GRANULATION; INVESTMENTS; PRODUCTION;

CAPITAL INVESTMENTS;

DRUG PRODUCTS PLANTS;

DRYING; GRANULATION; PROCESSING TECHNIQUE; SCALE EFFECT;

BATCH PROCESS; CAPITAL; CLEANING; CONCEPT FORMATION; CONFERENCE PAPER; CONTINUOUS PROCESS; DRUG FORMULATION; DRUG GRANULATION; DRUG GRANULE; DRUG INDUSTRY; DRUG QUALITY; EQUIPMENT; INVESTMENT; SCALE UP; TABLET MANUFACTURE; TIME;

EID: 0037453886     PISSN: 00325910     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0032-5910(02)00270-X     Document Type: Conference Paper

References (9)

1. A. Schade, Herstellung von pharmazeutischen Granulaten in einem kombinierten Feuchtgranulations-und Mehrkammer-Wirbelschichttrocknungsverfahren, Dissertation Universität Basel, 1992.
2. Schade A., Leuenberger H. Herstellung pharmazeutischer Granulate in einem kombinierten Feuchtgranulations-und Mehrkammer-Wirbelschicuttrockungsverfahren. Chem.-Ing.-Tech. 64(11):1992;1016-1018.
3. B. Dörr, Entwicklung einer Anlage zur quasikontinuierlichen Feuchtgranulierung und Mehrkammer-Wirbelschichttrocknung von pharmazeutischen Granulaten, Dissertation Universität Basel, 1996.
4. Dörr B., Leuenberger H. Development of a quasi-continuous production line - a concept to avoid scale-up problems. Leuenberger H. Preprints First European Symposium on Process Technologies in Pharmaceutical and Nutritional Sciences, PARTEC 98 Nürnberg. 1998;247-256 Nürnberg Wesse, GmbH, D-90471, Nürnberg.
5. Leuenberger H. New trends in the production of pharmaceutical granules: the classical batch concept and the problem of scale-up. Eur. J. Pharm. Biopharm. 52:2001;279-288.
6. Leuenberger H. New trends in the production of pharmaceutical granules: batch versus continuous processing. Eur. J. Pharm. Biopharm. 52:2001;289-298.
7. Leuenberger H. Scale-up in the 4th dimension in the field of granulation and drying. (Chapter 6) Levin M. Pharmaceutical Process Scale-up. Drugs and Pharmaceutical Sciences. vol. 118:2001;151-170 Marcel Dekker, New York, Basel. (ISBN 0-8247-0625-0).
8. Leuenberger H. Scale-up in the 4th dimension in the field of granulation and drying. Preprints, 7th Int. Symposium on Agglomeration 2001, Albi, France, May 29-31. 2001;375-389.
9. B. Dörr, private communication.