Structure-based design of inhibitors of human L-xylulose reductase modelled into the active site of the enzyme

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 8, 2003, Pages 1469-1474

  Carbone, Vincenzo ^a   Darmanin, Connie ^a   Ishikura, Shuhei ^b   Hara, Akira ^b   El Kabbani, Ossama ^a  

^a MONASH UNIVERSITY   (Australia)

^b GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CARBONYL DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; HOLOENZYME; HYDROXYL GROUP; LEVO XYLULOSE OXIREDUCTASE; METHYL GROUP; OXIDOREDUCTASE; OXIDOREDUCTASE INHIBITOR; PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG ACTIVITY; DRUG BINDING; DRUG DESIGN; DRUG INHIBITION; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME BINDING; STRUCTURE ACTIVITY RELATION;

EID: 0037451818     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(03)00166-5     Document Type: Article

References (18)

1. Touster O., Reynolds V.H., Hutcheson R.M. J. Biol. Chem. 221:1954;697.
2. Hollmans, S.; Touster, O. In: Non-Glycolytic Pathways of Metabolism of Glucose. New York/London, Academic Press, 1964, pp 107-113.
3. Sochor M., Baquer N.Z., Mclean P. Arch. Biochem. Biophys. 198:1979;632.
4. Weingrad A.I., Burden C.L. New Eng. J. Med. 274:1966;298.
5. Nakagawa J., Ishikura S., Asami J., Isaji T., Usami N., Hara A., Sakurai T., Tsuritani K., Oda K., Takahashi M., Yoshimoto M., Otsuka N., Kitamura K. J. Biol. Chem. 277:2002;17883.
6. Goode D., Lewis M.E., Crabbe J.C. FEBS Lett. 395:1996;174.
7. Jörnvall H., Persson B., Krook M., Atrian S., Gonzalez-Duarte R., Jeffery J., Ghosh D. Biochemistry. 34:1995;6003.
8. Ishikura, S.; Isaji, T.; Usami, N.; Nakagawa, J.; El-Kabbani, O.; Hara, A. Chem.-Biol. Interact. In press.
9. Nakanishi M., Deyashiki Y., Ohshima K., Hara A. Eur. J. Biochem. 228:1995;381.
10. Thompson J.D., Higgins D.G., Gibson T.J. Nucleic Acids Res. 22:1994;4673.
11. Tanaka N., Nonaka T., Nakanishi M., Deyashiki Y., Hara A., Mitsui Y. Structure. 4:1996;33.
12. Roussel A., Fontecilla-Camps J.C., Cambillau C. Acta Crystallogr. Sect. A. 46:1990;C66.
13. Brünger A.T., Krukowski A., Erickson J.W. Acta Crystallogr. Sect. A. 46:1990;585.
14. Ewing, T. University of California, CA. 1998, DOCK manual version 4.0.
15. Goodford P. J. Med. Chem. 28:1985;849.
16. Darmanin C., El-Kabbani O. Bioorg. Med. Chem. Lett. 11:2001;3133.
17. Darmanin C., El-Kabbani O. Bioorg. Med. Chem. Lett. 10:2000;1101.
18. Kraulis P.J. J. Appl. Cryst. 24:1991;946.