A short synthesis of staurosporinone (K-252c)

Tetrahedron Letters

Volumn 44, Issue 12, 2003, Pages 2577-2578

  Gaudêncio, Susana P ^a   Santos, Maria M M ^a   Lobo, Ana M ^a   Prabhakar, Sundaresan ^a  

^a UNIVERSIDADE NOVA DE LISBOA   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALOID; K 252C; STAUROSPORINONE; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; INFRARED SPECTROSCOPY; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 0037450946     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(03)00279-X     Document Type: Article

References (26)

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23. 2 was taken up in EtOAc and washed with a bicarbonate solution. The solid obtained (1.14 g) on evaporation of the combined organic solutions was chromatographed (silica; EtOAc-MeOH, 40:1) to furnish, in increasing order of polarity the unreacted 3 (146.6 mg, 28%), the imide 5a (133 mg, 15%) and the lactam 5b (390 mg; 57%). Based on recovered 3 and the conversion of 5a into 5b (see below) the overall yield of the latter compound is >95%.
24. 3O: 313.12150. Found: 313.12143.
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