A facile synthesis of 4- and 6-chloromethyl-1H-indole-2-carboxylates: Replacement of a sulfonic acid functionality by chlorine

Tetrahedron Letters

Volumn 44, Issue 12, 2003, Pages 2537-2539

  Pete, Béla ^a   Parlagh, Gyula ^a  

^a BUDAPEST UNIVERSITY OF TECHNOLOGY AND ECONOMICS   (Hungary)

Author keywords

4 (chloromethyl)indoles; 6 (chloromethyl)indoles; Desulfination; Fischer synthesis

Indexed keywords

CARBOXYLIC ACID DERIVATIVE; CHLORINE; METHYL GROUP; SULFONIC ACID DERIVATIVE;

ARTICLE; CHEMICAL REACTION; CHLORINATION; FISCHER TYPE INDOLIZATION; SYNTHESIS;

EID: 0037450930     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(03)00327-7     Document Type: Article

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12. 3) for 7a and 7b: 7a: δ 1.40 (3H, t, J=7 Hz), 1.98 (2H, m), 2.24 (6H, s), 2.45 (2H, m), 3.36 (2H, m), 3.65 (3H, s), 3.68 (2H, s), 4.39 (2H, q, J=7 Hz), 6.96 (1H, d, J=8 Hz), 7.21 (1H, t, J=8 Hz), 7.26 (1H, d, J=8 Hz), 8.78 (1H, s). 7b: δ 1.41 (3H, t, J=7 Hz), 2.01 (2H, m), 2.30 (6H, s), 2.36 (2H, m), 3.14 (2H, m), 3.57 (2H, s), 3.63 (3H, s), 4.39 (2H, q, J=7 Hz), 7.09 (1H, d, J=8.3 Hz), 7.35 (1H, s), 7.61 (1H, d, J=8.3 Hz), 8.83 (1H, s).
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