Intravenous injection of naked plasmid DNA encoding hepatitis B virus (HBV) produces HBV and induces humoral immune response in mice

Biochemical and Biophysical Research Communications

Volumn 300, Issue 3, 2003, Pages 784-788

  Suzuki, Takahiro ^a   Takehara, Tetsuo ^a   Ohkawa, Kazuyoshi ^a   Ishida, Hisashi ^a   Jinushi, Masahisa ^a   Miyagi, Takuya ^a   Sasaki, Yutaka ^a   Hayashi, Norio ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Animal model; Gene expression; Gene transfer; Hepatitis B virus; Hydrodynamics based gene delivery; Mouse; Naked plasmid DNA; Replication

Indexed keywords

CORE PROTEIN; DEOXYRIBONUCLEASE I; MEMBRANE ANTIGEN; PLASMID DNA; VIRUS ANTIGEN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DENSITY; FRACTIONATION; GENETIC CODE; GENOME; HEPATITIS B VIRUS; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOCOMPETENCE; LIVER CELL; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TAIL; TIME; VIRUS MUTATION; VIRUS REPLICATION; VIRUS TRANSCRIPTION;

ANIMALIA; HEPATITIS B VIRUS; PRIMATES;

EID: 0037449866     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)02889-9     Document Type: Article

References (15)

1. Araki K., Miyazaki J., Hino O., Tomita N., Chisaka O., Matsubara K., Yamamura K. Expression and replication of hepatitis B virus genome in transgenic mice. Proc. Natl. Acad. Sci. USA. 86:1989;207-211.
2. Guidotti L.G., Matzke B., Schaller H., Chisari F.V. High level hepatitis B virus replication in transgenic mice. J. Virol. 69:1995;6158-6169.
3. Takehara T., Hayashi N., Miyamoto Y., Yamamoto M., Mita E., Fusamoto H., Kamada T. Expression of the hepatitis C virus genome in rat liver after cationic liposome-mediated in vivo gene transfer. Hepatology. 21:1995;746-751.
4. Takahashi H., Fujimoto J., Hanada S., Isselbacher K.J. Acute hepatitis in rats expressing human hepatitis B virus transgenes. Proc. Natl. Acad. Sci. USA. 92:1995;1470-1474.
5. Sprinzl M.F., Oberwinkler H., Schaller H., Protzer U. Transfer of hepatitis B virus genome by adenovirus vectors into cultured cells and mice: crossing the species barrier. J. Virol. 75:2001;5108-5118.
6. Liu F., Song Y.K., Liu D. Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA. Gene Ther. 6:1999;1258-1266.
7. Zhang G., Budker V., Wolff J.A. High levels of foreign gene expression in hepatocytes after tail vein injection of naked plasmid DNA. Hum. Gene Ther. 10:1999;1735-1737.
8. Bruss V., Ganem D. The role of envelope proteins in hepatitis B virus assembly. Proc. Natl. Acad. Sci. USA. 88:1991;1059-1063.
9. Ishida H., Ueda K., Ohkawa K., Kanazawa Y., Hosui A., Nakanishi F., Mita E., Kasahara A., Sasaki Y., Hori M., Hayashi N. Identification of multiple transcription factors, HLF, FTF, and E4BP4, controlling hepatitis B virus enhancer II. J. Virol. 74:2000;1241-1251.
10. Jiang J., Yamato E., Miyazaki J. Intravenous delivery of naked plasmid DNA for in vivo cytokine expression. Biochem. Biophys. Res. Commun. 289:2001;1088-1092.
11. Kawanishi Y., Hayashi N., Katayama K., Ueda K., Takehara T., Miyoshi E., Mita E., Kasahara A., Fusamoto H., Kamada T. Tumor necrosis factor-. α and interleukin- γ inhibit synergistically viral replication in hepatitis B virus-replicating cells J. Med. Virol. 47:1995;272-277.
12. Takehara T., Hayashi N., Yamamoto M., Miyamoto Y., Fusamoto H., Kamada T. In vivo gene transfer and expression in rat stomach by submucosal injection of plasmid DNA. Hum. Gene Ther. 7:1996;589-593.
13. Nassal M., Schaller H. Hepatitis B virus replication - an update. J. Viral. Hepat. 3:1996;217-226.
14. Kaplan P.M., Ford E.C., Purcell R.H., Gerin J.L. Demonstration of subpopulation of Dane particles. J. Virol. 17:1976;885-893.
15. Yang P.L., Althage A., Chung J., Chisari F.V. Hydrodynamic injection of viral DNA: a mouse model of acute hepatitis B virus infection. Proc. Natl. Acad. Sci. USA. 99:2002;13825-13830.