Anti-MRSA cephems. Part 3: Additional C-7 acid derivatives

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 2, 2003, Pages 281-291

  Springer, Dane M ^a,b   Luh, Bing Yu ^a   Goodrich, Jason T ^a   Bronson, Joanne J ^a  

^a BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

^b Rib X Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; AROMATIC COMPOUND; CEPHALOSPORIN DERIVATIVE; CINNAMIC ACID DERIVATIVE; IMIPENEM; VANCOMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DRUG SYNTHESIS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; STILLE REACTION; SUBSTITUTION REACTION; ANIMAL; CHEMISTRY; DISEASE MODEL; DRUG EFFECT; LD 50; MICROBIOLOGICAL EXAMINATION; MICROBIOLOGY; PATHOGENICITY; PENICILLIN RESISTANCE; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-BACTERIAL AGENTS; CEPHALOSPORINS; DISEASE MODELS, ANIMAL; LETHAL DOSE 50; METHICILLIN RESISTANCE; MICE; MICROBIAL SENSITIVITY TESTS; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037449357     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(02)00335-8     Document Type: Article

References (6)

1. Springer, D. M.; Luh, B.-Y.; Goodrich, J. T.; Bronson, J. J.
2. Springer D.M., Luh B.-Y., D'Andrea S.V., Hudyma T.W., Kim O.K. International Patent Application WO-9823621, 1998. Chem. Abstr. 129:1998;54236.
3. Huffman G.W. US Patent 3,907,784, 1975. Chem. Abstr. 84:1975;17395.
4. Singh J., Kim O.K., Kissick T.P., Natalie K.J., Zhang B., Crispino G.A., Springer D.M., Wichtowski J.A., Zhang Y., Goodrich J., Ueda Y., Luh B.Y., Burke B.D., Brown M., Dutta A.P., Zheng B., Hsieh D.M., Humora M.J., North J.T., Pullockaran A.J., Livshits J., Swaminathan S., Gao Z., Schierling P., Ermann P., Perrone R.K., Lai M.C., Gougoutas J.Z., DiMarco J.D., Bronson J.J., Heikes J.E., Grosso J.A., Kronenthal D.R., Denzel T.W., Mueller R.H. Org. Process Res. Dev. 4:2000;488.
5. For a description of the synthesis of this type of compound, see ref 1, footnote 13.
6. The sodium salt of methyl mercaptoacetate is made fresh prior to use. For a discussion of the synthesis and handling of this reagent, see ref 1.