Effect of domperidone on ventilation and polycythemia after 5 weeks of chronic hypoxia in rats

Respiratory Physiology and Neurobiology

Volumn 135, Issue 1, 2003, Pages 1-8

  Gamboa, J ^a   Macarlupu J L ^a   Rivera Chira, M ^a   Monge C , C ^a   Leon Velarde F ^a  

^a UNIVERSIDAD PERUANA CAYETANO HEREDIA   (Peru)

Author keywords

Control of breathing; Hemoglobinpolycythemia; Hypoxiadopamine receptors; Hypoxic ventilatory response; Mammalsrat; Pharmacological agentsdomperidone; Receptorsdopamine

Indexed keywords

DOMPERIDONE; DOPAMINE RECEPTOR BLOCKING AGENT; HEMOGLOBIN; NETAPH;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMOSENSITIVITY; CONTROLLED STUDY; DOPAMINE RECEPTOR BLOCKING; DRUG EFFECT; HEMOGLOBIN DETERMINATION; HYPOBARISM; HYPOXIA; LUNG CAPACITY; LUNG MINUTE VOLUME; LUNG VENTILATION; MALE; NONHUMAN; POLYCYTHEMIA; PRIORITY JOURNAL; RAT; RESPIRATORY FUNCTION;

EID: 0037447243     PISSN: 15699048     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1569-9048(03)00065-X     Document Type: Article

References (38)

1. Arias-Stella A., Valcarcel J. Chief cell hyperplasia in the human carotid body at high altitude. Human Pathol. 7:1976;361-373.
2. Bartlett D. Jr., Tenney S.M. Control of Breathing in experimental anemia. Respir. Physiol. 10:1970;384-395.
3. Bee D., Pallot D.J. Acute hypoxic ventilation, carotid body cell division, and dopamine content during early hypoxia in rats. J. Appl. Physiol. 79:1995;1504-1511.
4. Champion M.C. Domperidone. Gen. Pharmac. 19:1988;499-505.
5. Dhillon D.P., Barer G.R., Walsh M. The enlarged carotid body of the chronically hypoxic and hypercapnic rat: a morphometric study. Quart. J. Exp. Physiol. 69:1984;301-317.
6. Edwards C., Heath D., Harris P., Castillo Y., Kruger H., Arias-Stella J. The carotid body in animal at high altitude. J. Pathol. 104:1971;231-238.
7. Gonzalez C., Almaraz L., Obeso A., Rigual R. Carotid body chemoreceptors: from natural stimuli to sensory discharges. Physiol. Rev. 74:1994;829-898.
8. Gonzalez C., Lopez-Lopez J.R., Obeso A., Perez-García M.T., Rocher A. Cellular mechanisms of chemoreception in the carotid body. Respir. Physiol. 102:1995;137-147.
9. Hellstrom S., Hanbauer I., Costa E. Selective decrease of dopamine content in rat carotid body during exposure to hypoxic conditions. Brain Res. 118:1976;352-355.
10. Hsiao C., Lahiri S., Mokashi A. Peripheral and central dopamine receptors in respiratory control. Respir. Physiol. 76:1989;327-336.
11. Huey K.A., Low M.J., Kelly M.A., Juarez R., Szewczak J.M., Powell F.L. Ventilatory responses to acute and chronic hypoxia in mice: effects of dopamine D(2) receptors. J. Appl. Physiol. 89:(3):2000;1142-1150.
12. Huey K.A., Brown I.P., Jordan M.C., Powell F.L. Changes in dopamine D2-receptor modulation of the hypoxic ventilatory response with chronic hypoxia. Respir. Physiol. 123:2000;177-187.
13. Huey K.A., Powell F.L. Time dependent changes in dopamine D2-mRNA in the arterial chemoreflex pathway with chronic hypoxia. Brain Res. Mol. 75:2000;264-270.
14. Iturriaga R., Larrain C., Zapata P. Effects of dopaminergic blockade upon carotid chemosensory activity and its hypoxia-induced excitation. Brain Res. 663:1994;145-154.
15. Janssen P., O'Halloran K., Pizarro J., Dwinell M., Bisgard G.E. Carotid body dopaminergic mechanisms are functional after acclimatization to hypoxia in goats. Respir. Physiol. 111:1998;23-32.
16. Kryger M., McCullough R.E., Doekel R., Collins D.D., Weil J.V., Grover R.F. Excessive polycythemia of high altitude: role of ventilatory drive and lung disease. Am. Rev. Respir. Dis. 118:1978;659-666.
17. 2 sensing with special reference to the carotid body. Horbein T.F., Schoene R.B. High Altitude. An Exploration of Human Adaptation. Lung Biology in Health and Disease. 161:2001;101-121 Marcel Dekker, New York.
18. León-Velarde, F., Arregui, A., Monge, C.C., Ruiz y Ruiz, H., 1993. Ruiz y Ruiz H. Aging at high altitudes and the risk of chronic mountain sickness, J. Wild. Med., 4, 183-188.
19. McGregor K.H., Gil J., Lahiri S. A morphometric study of the carotid body in chronically hypoxic rats. J. Appl. Physiol. 57:1984;1430-1438.
20. Monge C.C., León-Velarde F., Arregui A. Pathophysiology and epidemiology of chronic mountain sickness. Int. J. Sports Med. 13:(Suppl. 1):1992;S79-S81.
21. Olson E.B., Dempsey J.A. Rat as a model for human like ventilatory adaptation to chronic hypoxia. J. Appl. Physiol. 44:1978;763-769.
22. Olson E.B. Jr., Vidruk E.H., Mc Crimon D.R., Dempsey J.A. Monoamine neurotransmitter metabolism during acclimatization to hypoxia in rats. Respir. Physiol. 54:1983;79-96.
23. Pedersen M.E.F., Dorrington K.L., Robbins P.A. Effects of dopamine and domperidone on ventilatory sensitivity to hypoxia after 8 h of isocapnic hypoxia. J. Appl. Physiol. 86:1999;222-229.
24. Pequignot J.M., Cottet-Emard J.M., Dalmaz Y., Peyrin L. Dopamine and nor epinephrine dynamics in rat carotid body during long-term hypoxia. J. Auton. Nerv. Syst. 21:1987;9-14.
25. Powell F.L., Huey K.A., Dwinell M.R. Central nervous system mechanisms of ventilatory acclimatization to hypoxia. Respir. Physiol. 121:2000;223-236.
26. Rahn H., Otis A.B. Man's respiratory response during and after acclimatization to high altitude. Am. J. Physiol. 157:1949;445-462.
27. Severinghaus J.W., Bainton G.R., Carcelen A. Respiratory insensitivity to hypoxia in chronically hypoxic man. Respir. Physiol. 1:1966;308-334.
28. Sime F., Monge C.C., Whittembury J. Age as a cause of chronic mountain sickness (Monge's disease). Int. J. Biometeor. 19:1975;93-98.
29. Smith C.A., Bisgard G.E., Nielsen A.M., Daristotle L., Kressin N.A., Forster H.F., Dempsey J.A. Carotid bodies are required for ventilatory acclimatization to chronic hypoxia. J. Appl. Physiol. 60:1986;1003-1010.
30. Solomon I.C. Excitation of phrenic and sympathetic output during acute hypoxia: contribution of medullary oxygen detectors. Respir. Physiol. 121:2000;101-117.
31. Tatsumi K., Pickett C.K., Weil J.V. Possible role of dopamine in ventilatory acclimatization to high altitude. Respir. Physiol. 99:1995;63-73.
32. Tenney S.M., Ou L.C. Hypoxic ventilatory response of cats at high altitude, an interpretation of blunting. Respir. Physiol. 30:1977;185-199.
33. Velasquez T., Martinez C., Pezzia W., Gallardo N. Ventilatory effects of oxygen in high altitude natives. Respir. Physiol. 5:1968;211-220.
34. Vizek M., Pickett C.K., Weil J.V. Increased carotid body hypoxic sensitivity during acclimatization to hypobaric hypoxia. J. Appl. Physiol. 63:1987;2403-2410.
35. Weil J.V., Byrne-Quinn E., Sodal I.E., Filley G.F., Grover R.F. Acquired attenuation of chemoreceptor function in chronically hypoxic man at high altitude. J. Clin. Invest. 50:1971;186-195.
36. Wu, T.Y., Li, W., Li, Y., Ge, R.L., Cheng, Q., Wang, S., Zhao, G., Wei, L., Jin, Y., Don, G., 1998. Epidemiology of chronic mountain sickness: ten years study in Quinghai-Tibet. In: Ohno H, Kobayashi T, Masuyama S, Nakashima M, (eds.), Progress in Mountain Medicine and High Altitude Physiology. Publisher: Press Committee of the Third World Congress on Mountain Medicine and High Altitude Physiology, Matsumoto, Japan.
37. Zapata P., Torrealba F. Blockade of dopamine-induced chemosensory inhibition by domperidone. Neurosci. Lett. 51:1984;359-364.
38. Zapata P., Iturriaga R., Larrain C. Domperidone as a tool to assess the role of dopamine within carotid body chemoreception. Adv. Exp. Med. Biol. 410:1996;291-297.