Human transthyretin intronic open reading frames are not independently expressed in vivo or part of functional transcripts

Biochimica et Biophysica Acta - Gene Structure and Expression

Volumn 1626, Issue 1-3, 2003, Pages 65-74

  Soares, Miguel Luz ^a,b   Centola, Michael ^a   Chae, JaeJin ^a   Saraiva, Maria João ^b,c   Kastner, Daniel L ^a  

^a NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

^b UNIVERSITY OF PORTO   (Portugal)

^c UNIVERSITY OF PORTO   (Portugal)

Author keywords

Expression; mRNA; Open reading frame; Transthyretin

Indexed keywords

PREALBUMIN;

ARTICLE; BRAIN; CONTROLLED STUDY; DNA SEQUENCE; GENE AMPLIFICATION; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; INTRON; LIVER; OPEN READING FRAME; PANCREAS; PRIORITY JOURNAL; PROMOTER REGION; TISSUE DISTRIBUTION;

EID: 0037446475     PISSN: 01674781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4781(03)00043-5     Document Type: Article

References (34)

1. Dickson P.W., Schreiber G. High levels of messenger RNA for transthyretin (prealbumin) in human choroid plexus. Neurosci. Lett. 66:1986;311-315.
2. Martone R.L., Herbert J., Dwork A., Schon E.A. Transthyretin in synthesized in the mammalian eye. Biochem. Biophys. Res. Commun. 151:1988;905-912.
3. Jacobsson B. In situ localization of transthyretin mRNA in the adult human liver, choroid plexus and pancreatic islets and in endocrine tumors of the pancreas and guts. Histochemistry. 91:1989;299-304.
4. Martone R.L., Mizuno R., Herbert J. The mammalian pineal gland is a synthetic site for TTR and RBP. J. Rheumatol. 20:1993;175.
5. Saraiva M.J.M., Birken S., Costa P.P., Goodman D. Amyloid fibril protein in familial amyloidotic polyneuropathy, Portuguese type. Definition of molecular abnormality in transthyretin (prealbumin). J. Clin. Invest. 74:1984;104-109.
6. Whitehead A.S., Skinner M., Bruns G.A.P., Costello W., Edge M.D., Cohen A.S., Sipe J.D. Cloning of human prealbumin complementary DNA. Localization of the gene to chromosome 18 and detection of a variant prealbumin allele in a family with familial amyloid polyneuropathy. Mol. Biol. Med. 2:1984;411-423.
7. Tsuzuki T., Mita S., Maeda S., Araki S., Shimada K. Structure of the human prealbumin gene. J. Biol. Chem. 260:1985;12224-12227.
8. Kozak M. Interpreting cDNA sequences: some insights from studies on translation. Mamm. Genome. 7:1996;562-574.
9. Ferat J.-L., Michel L. Group II self-splicing introns in bacteria. Nature. 364:1993;358-361.
10. Lazowsca J., Jacq C., Slonimski P.P. Sequence of introns and flanking exons in wild-type and box3 mutants of cytochrome b reveals an interlaced splicing protein coded by an intron. Cell. 22:1980;333-348.
11. Henikoff S., Keene M.A., Fechtel K., Fristrom J.W. Gene within a gene: nested Drosophila genes encode unrelated proteins on opposite DNA strands. Cell. 44:1986;33-42.
12. Chen C., Malone T., Beckendorf S.K., Davis R.L. At least two genes reside within a large intron of the dunce gene of Drosophila. Nature. 329:1987;721-724.
13. Adelman J.P., Bond C.T., Douglass J., Herbert E. Two mammalian genes transcribed from opposite strands of the same DNA locus. Science. 235:1987;1514-1517.
14. Williams T., Fried M. A mouse locus at which transcription from both DNA strands produces mRNAs complementary at their 3′ ends. Nature. 322:1986;275-279.
15. Levinson B., Kenrick S., Lakich D., Hammonds G., Gitschier J. A transcribed gene in an intron of the human factor VIII gene. Genomics. 7:1990;1-11.
16. Levinson B., Bermingham J., Metzenberg A., Chapman V., Gitschier J. The sequence of the human factor VIII associated gene is conserved in the mouse. Genomics. 13:1992;862-865.
17. O'Connell P., Viskochil D., Buchberg A., Fountain J., Cawthon R., Culve M., Stevens J., Rich D.C., Ledbetter D.H., Wallace M., Carey J.C., Jenkins N., Copeland N., Collins F., White R. The human homologue of murine evi-2 lies between two translocation breakpoints associated with von Recklinghausen neurofibromatosis. Genomics. 5:1990;547-554.
18. Cawthon R.M., Andersen L.B., Buchberg A.M., Xu G., O'Connell P., Viskochil D., Weiss R.B., Wallace M.R., Marchuk D.A., Culver M., Stevens J., Jenkins N.A., Copeland N.G., Collins F.S., White R. cDNA sequence and genomic structure of EVI2B, a gene lying within an intron of the neurofibromatosis type 1 gene. Genomics. 9:1991;446-460.
19. Viskochil D., Cawthon R.M., O'Connell P., Xu G., Stevens J., Culver M., Carey J., White R. The gene encoding the oligodendrocyte-myelin glycoprotein is embedded within the neurofibromatosis type 1 gene. Mol. Cell. Biol. 11:1991;906-912.
20. Altschul S.F., Gish W., Miller W., Myers E.W., Lipman D.J. Basic local alignment search tool. J. Mol. Biol. 5:1990;403-410.
21. Schreiber G., Richardson S.J. The evolution of gene expression, structure and function of transthyretin. Comp. Biochem. Physiol. 116B:1997;137-160.
22. Aldred A.R., Prapunpoj P., Schreiber G. Evolution of a shorter and more hydrophilic transthyretin N-termini by step-wise conversion of exon 2 into intron 1 sequences (shifting the 3′ splice site of intron 1). J. Biol. Chem. 246:1997;401-419.
23. Blake C.C.F., Geisow M.J., Oatley S.J., Rérat B., Rérat C. Structure of prealbumin: secondary, tertiary and quaternary interactions determined by Fourier refinement at 1.8 Å J. Mol. Biol. 121:1978;339-356.
24. Attanasio C., David A., Neerman-Arbez M. Outcome of donor splice site mutations accounting for congenital afibrinogenemia reflects order of intron removal in the fibrinogen alpha gene (FGA). Blood. 2002;. (epub ahead of print).
25. Takahara K., Schwarze U., Imamura Y., Hoffman G.G., Toriello H., Smith L.T., Byers P.H., Greenspan D.S. Order of intron removal influences multiple splice outcomes, including a two-exon skip, in a COL5A1 acceptor-site mutation that results in abnormal pro-alpha1(V) N-propeptides and Ehlers-Danlos syndrome type I. Am. J. Hum. Genet. 71:2002;451-465.
26. Schwarze U., Starman B.J., Byers P.H. Redefinition of exon 7 in the COL1A1 gene of type I collagen by an intron 8 splice-donor-site mutation in a form of osteogenesis imperfecta: influence of intron splice order on outcome of splice-site mutation. Am. J. Hum. Genet. 65:1999;336-344.
27. Kessler O., Jiang Y., Chasin L.A. Order of intron removal during splicing of endogenous adenine phosphoribosyltransferase and dihydrofolate reductase pre-mRNA. Mol. Cell. Biol. 13:1993;6211-6222.
28. Brockdorff N., Ashworth A., Kay G.F., McCabe V.M., Norris D.P., Cooper P.J., Swift S., Rastan S. The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus. Cell. 71:1992;515-526.
29. Brown C.J., Hendrich B.D., Rupert J.L., Lafreniere R.G., Xing Y., Lawrence J., Willard H.F. The human XIST gene: analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus. Cell. 71:1992;527-554.
30. Carthew R.W. Gene silencing by double-stranded RNA. Curr. Opin. Cell Biol. 13:2001;244-248.
31. Smith F.R., Goodman D.S. The effects of diseases of the liver, thyroid, and kidneys on the transport of vitamin A in human plasma. J. Clin. Invest. 50:1971;2426.
32. Shetty P.S., Watrasiewicz R.E., Jung R.T., James W.P.T. Rapid-turnover transport proteins: an index of sub-clinical protein-energy malnutrition. Lancet. 2:1979;230-232.
33. Qian X., Samadani U., Porcella A., Costa R.H. Decreased expression of hepatocyte nuclear factor 3α during the acute-phase response influences transthyretin gene transcription. Mol. Cell. Biol. 15:1995;1364-1376.
34. Baumann H., Gauldie J. The acute phase response. Immunol. Today. 15:1994;74-80.