Rapid analysis of metabolic stability of dopamine receptor antagonists and detection of their metabolites by liquid chromatography/tandem mass spectrometry

Analytical Biochemistry

Volumn 313, Issue 2, 2003, Pages 292-300

  Lee, Jaeick ^a   Son, Junghyun ^a   Koh, Hun Yeoung ^a   Pae, Ae Nim ^a   Kim, Dong Hyun ^a  

^a Korea Institute of Science and Technology   (South Korea)

Author keywords

Cassette analysis; In vitro metabolic stability; Ion trap mass spectrometry; Metabolite

Indexed keywords

AMINES; BIOMOLECULES; DRUG PRODUCTS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROXYLATION; IONS; MASS SPECTROMETRY; METABOLISM; NEUROPHYSIOLOGY; RATS; STABILITY;

CASSETTE ANALYSIS; HYDROXYLATION REACTIONS; ION-TRAP MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; METABOLIC STABILITY; SIMULTANEOUS DETECTION; STRUCTURAL CHARACTERIZATION; TANDEM MASS SPECTROMETRY;

METABOLITES;

DOPAMINE RECEPTOR BLOCKING AGENT; DRUG METABOLITE; ISOXAZOLE DERIVATIVE; KCH 1058; KCH 1059; KCH 1081; KCH 1109; KCH 1110; KCH 716; KCH 728; KCH 730; KCH 732; KCH 743; KCH 746; KCH 747; KCH 748; KCH 760; KCH 761; KCH 764; KCH 766; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DEALKYLATION; DRUG SCREENING; DRUG STABILITY; HYDROXYLATION; IN VITRO STUDY; INCUBATION TIME; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; TANDEM MASS SPECTROMETRY;

EID: 0037442437     PISSN: 00032697     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-2697(02)00628-0     Document Type: Article

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