Phase II study of the efficacy and safety of cisplatin-epinephrine injectable gel administered to patients with unresectable hepatocellular carcinoma

Journal of Clinical Oncology

Volumn 21, Issue 4, 2003, Pages 652-658

  Leung, Thomas W T ^a   Yu, S ^a   Johnson, P J ^a   Geschwind, J ^a   Vogl, T J ^a   Engelmann, K ^a   Gores, G J ^a   Giovannini, M ^a   O'Grady, J ^a   Heneghan, M ^a   Stewart, M ^a   Orenberg, E K ^a   Thuluvath, P J ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; CISPLATIN; ANTINEOPLASTIC AGENT;

AGED; ARTICLE; CANCER SURVIVAL; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; COMPUTER ASSISTED TOMOGRAPHY; DRUG EFFICACY; DRUG FORMULATION; DRUG SAFETY; DRUG TOLERABILITY; HUMAN; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; TREATMENT OUTCOME; TREATMENT RESPONSE; UNSPECIFIED SIDE EFFECT; ADULT; DRUG COMBINATION; FEMALE; GEL; INTRALESIONAL DRUG ADMINISTRATION; LIVER TUMOR; MALE; MIDDLE AGED; MORTALITY; MULTICENTER STUDY; PATHOLOGY; SURVIVAL RATE;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS; CARCINOMA, HEPATOCELLULAR; CISPLATIN; DRUG COMBINATIONS; EPINEPHRINE; FEMALE; GELS; HUMANS; INJECTIONS, INTRALESIONAL; LIVER NEOPLASMS; MALE; MIDDLE AGED; SURVIVAL RATE;

EID: 0037441655     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2003.04.152     Document Type: Article

References (32)

1. Howe HL, Wingo PA, Thun MJ, et al: Annual report to the nation on the status of cancer (1973 through 1998), featuring cancers with recent increasing trends. J Natl Cancer Inst 93:824-842, 2001
2. Bosch FX: Global epidemiology of hepatocellular carcinoma, in Okuda K (ed): Liver Cancer. New York, NY, Churchill Livingstone, 1997, pp 13-28
3. Ogunbiyi JO: Hepatocellular carcinoma in the developing world. Semin Oncol 28:179-187, 2001
4. El-Serag HB, Mason AC: Rising incidence of hepatocellular carcinoma in the United States. N Engl J Med 340:745-750, 1999
5. Taylor-Robinson SD, Foster GR, Arora S, et al: Increase in primary liver cancer in the UK, 1979-94. Lancet 350:1142-1143, 1997
6. Flickinger JC, Carr BI, Lotze MT: Cancer of the liver, in DeVita VT, Hellman S, Rosenberg SA (eds): Cancer: Principles and Practice of Oncology (ed 5). Philadelphia, PA, Lippincott-Raven, 1997, pp 1087-1097
7. Pompili M, Rapaccini GL, Covino M, et al: Prognostic factors for survival in patients with compensated cirrhosis and small hepatocellular carcinoma after percutaneous ethanol injection therapy. Cancer 92:126-135, 2001
8. Sherlock S: Viruses and hepatocellular carcinoma. Gut 35:828-832, 1994
9. Okuda K: Hepatocellular carcinoma: Recent progress. Hepatology 15:948-963, 1992
10. Bruix J, Sherman M, Llovet JM, et al: Clinical management of hepatocellular carcinoma: Conclusions of the Barcelona-2000 EASL conference. European Association for the Study of the Liver. J Hepatol 35:421-430, 2001
11. Livraghi T, Bolondi L, Lazzaroni S, et al: Percutaneous ethanol injection in the treatment of hepatocellular carcinoma in cirrhosis: A study on 207 patients. Cancer 69:925-929, 1992
12. Curley SA, Izzo F, Ellis LM, et al: Radiofrequency ablation of hepatocellular cancer in 110 patients with cirrhosis. Ann Surg 232:381-391, 2000
13. Ohmoto K, Miyake I, Tsuduki M, et al: Percutaneous microwave coagulation therapy for unresectable hepatocellular carcinoma. Hepatogastroenterology 46:2894-2900, 1999
14. Mok TSK, Kanekal S, Lin XR, et al: Pharmacokinetic study of intralesional cisplatin for the treatment of hepatocellular carcinoma. Cancer 91:2369-2377, 2001
15. Begg AC, Bartelink H, Stewart FA, et al: Improvement of differential toxicity between tumor and normal tissues using intratumoral injection with or without a slow-drug-release matrix system. NCI Monogr 6:133-136, 1988
16. Yu NY, Patawaran MB, Chen JY, et al: Influence of treatment sequence on efficacy of fluorouracil and cisplatin intratumoral drug delivery in vivo. Cancer J Sci Am 1:215-221, 1995
17. Burris HA III, Vogel CL, Castro D, et al: Intratumoral cisplatin/epinephrine-injectable gel as a palliative treatment for accessible solid tumors: A multicenter pilot study. Otolaryngol Head Neck Surg 118:496-503, 1998
18. Curley SA, Carrasco CH, Charnsangavej C, et al: Phase I trial of intratumoral cisplatin therapeutic implant (MPI 5010) in patients with primary or metastatic cancer of liver. Proc Am Soc Clin Oncol 13:640, 1994 (abstr 640)
19. Izumi N, Asahina Y, Noguchi O, et al: Risk factors for distant recurrence of hepatocellular carcinoma in the liver after complete coagulation by microwave or radiofrequency ablation. Cancer 91:949-956, 2001
20. Livraghi T, Goldberg SN, Lazzaroni S, et al: Small hepatocellular carcinoma: Treatment with radio-frequency ablation versus ethanol injection. Radiology 210:655-661, 1999
21. Olschewski M, Lencioni R, Allgaier H, et al: A randomized comparison of radio-frequency thermal ablation and percutaneous ethanol injection for the treatment of small hepatocellular carcinoma. Proc Am Soc Clin Oncol 20:126, 2001 (abstr 500)
22. Seki T, Wakabayashi M, Nakagawa T, et al: Percutaneous microwave coagulation therapy for patients with small hepatocellular carcinoma: Comparison with percutaneous ethanol injection therapy. Cancer 85:1694-1702, 1999
23. Ikeda M, Okada S, Ueno H, et al: Radiofrequency ablation and percutaneous ethanol injection in patients with small hepatocellular carcinoma: A comparative study. Jpn J Clin Oncol 31:322-326, 2001
24. Monga SP, Wadleigh R, Adib H, et al: Endoscopic treatment of gastric cancer with intratumoral cisplatin/epinephrine injectable gel: A case report. Gastrointest Endosc 48:415-417, 1998
25. Monga SP, Wadleigh R, Sharma A, et al: Intratumoral therapy of cisplatin/epinephrine injectable gel for palliation in patients with obstructive esophageal cancer. Am J Clin Oncol 23:386-392, 2000
26. Harbord M, Dawes RF, Barr H, et al: Palliation of patients with dysphagia due to advanced esophageal cancer by endoscopic injection of cisplatin/epinephrine gel. Gastrointest Endosc 56:644-651, 2002
27. Vogl T, Engelmann K, Mack MG, et al: CT-guided intratumoral administration of cisplatin/epinephrine injectable gel for treatment of malignant liver tumors. Br J Cancer 86:524-529, 2002
28. Wenig BL, Werner JA, Castro DJ, et al: The role of intratumoral therapy with cisplatin/epinephrine injectable gel in the management of advanced squamous cell carcinoma of the head and neck. Arch Otolaryngol Head Neck Surg 128:880-885, 2002
29. Roshon S, Fernando I, Mansi J, et al: Control of locally recurrent breast cancer with intratumoral cisplatin/epinephrine injectable gel. Breast Cancer Res Treat 69:283, 2001 (abstr)
30. Oratz R, Hauschild A, Sebastian G, et al: Intratumoral cisplatin/epinephrine gel for treatment of patients with cutaneous and soft tissue metastases of malignant melanoma. Melanoma Res (in press)
31. Yu SCH, Chan YL, Leung TWT, et al: Local effect of cisplatin/epinephrine injectable gel on intrahepatic lesions of hepatocellular carcinoma. Eur J Cancer 35:S146, 1999 (suppl 4)
32. Geschwind JF, Torbenson M, Kim HS, et al: Effects of direct intratumoral injection of cisplatin/epinephrine gel in a rabbit model of liver cancer. J Vasc Interven Radiol 13:S91, 2002 (suppl 1)