The use of combi chem, high-speed analog chemistry and HTS in drug discovery

Drug Discovery Today

Volumn 8, Issue 4, 2003, Pages 156-

  DeSimone, Robert W ^a  

^a Cellular Genomics ^*  (United States)

Author keywords

Combi chem; Drug Discovery; High speed analogue chemistry; HTS; Pharmaceutical Science; Techniques Methods

Indexed keywords

BENZODIAZEPINE DERIVATIVE; ION CHANNEL;

CHEMISTRY; COMBINATORIAL CHEMISTRY; DRUG INDUSTRY; DRUG MANUFACTURE; DRUG POTENCY; DRUG SPECIFICITY; DRUG SYNTHESIS; HIGH SPEED ANALOG CHEMISTRY; INTERMETHOD COMPARISON; NOTE; SIGNAL TRANSDUCTION;

COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DELIVERY SYSTEMS; DRUG DESIGN; HUMANS;

EID: 0037441516     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(03)02597-2     Document Type: Note

References (5)

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2. Lipinski C.A., et al. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Rev. 46:2001;3-26.
3. Manly C.M. The impact of informatics and computational chemistry on synthesis and screening. Drug Discov. Today. 6:2001;1101-1110.
4. Evans B.E., et al. Methods of drug discovery: development of potent, selective, orally effective cholecystokinin antagonists. J. Med. Chem. 31:1988;2235-2246.
5. Budde R.J.A. (2000) Inhibitors of protein tyrosine kinases. US Patent No 6,100,254.