Suppression of activated microglia promotes survival and function of transplanted oligodendroglial progenitors

GLIA

Volumn 41, Issue 2, 2003, Pages 191-198

  Zhang, Su Chun ^a,b   Goetz, Brian D ^a,c   Duncan, Ian D ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c Esperion Therapeutics Inc   (United States)

Author keywords

Cell death; Gliosis; Long Evans shaker

Indexed keywords

MINOCYCLINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ACTIVATION; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; CELL TRANSPLANTATION; CONTROLLED STUDY; DEMYELINATING DISEASE; GLIOSIS; MICROGLIA; MYELINATION; NEWBORN; NONHUMAN; OLIGODENDROGLIA; RAT; RAT STRAIN; SPINAL CORD;

ANIMALS; ANIMALS, NEWBORN; BRAIN TISSUE TRANSPLANTATION; CELL SURVIVAL; CELLS, CULTURED; DEMYELINATING DISEASES; DISEASE MODELS, ANIMAL; GLIOSIS; GRAFT SURVIVAL; IMMUNOHISTOCHEMISTRY; MICROGLIA; MICROSCOPY, ELECTRON; MINOCYCLINE; NEURODEGENERATIVE DISEASES; OLIGODENDROGLIA; RATS; RATS, LONG-EVANS; RATS, MUTANT STRAINS; RECOVERY OF FUNCTION; STEM CELLS;

EID: 0037440419     PISSN: 08941491     EISSN: None     Source Type: Journal    
DOI: 10.1002/glia.10172     Document Type: Article

References (34)

1. Akiyama H, Barger S, Barnum S, et al. 2000. Inflammation and Alzheimer's disease. Neurobiol Aging 21:383-420.
2. Amin AR, Attur MG, Thakker GD, Patel PD, Vyas PR, Patel RN, Patel IR, Abramson SB. 1996. A novel mechanism of action of tetracyclines: effects on nitric oxide synthases. Proc Natl Acad Sci USA 93:14014-14019.
3. Archer D, Cuddon PA, Lipsitz D, Duncan ID. 1997. Myelination of the canine central nervous system by glial cell transplantation: a model for repair of human myelin disease. Nat Med 3:54-59.
4. Benveniste EN. 1997. Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitis. J Mol Med 75:165-173.
5. Brundula V, Rewcastle NB, Metz LM, Bernard CC, Yong VW. 2002. Targeting leukocyte MMPs and transmigration minocycline as potential therapy for multiple sclerosis. Brain 125:1297-1308.
6. Chen M, Ona V, Li M, et al. 2000. Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease. Nat Med 6:797-801.
7. Dirnagl U, Iadecola C, Moskowitz MA. 1999. Pathobiology of ischemic stroke: an integrated view. Trends Neurosci 22:391-397.
8. Frautschy SA, Yang F, Irrizarry M, Hyman B, Saido TC, Hsiao K, Cole GM. 1998. Microglial response to amyloid plaques in APPsw transgenic mice. Am J Pathol 152:307-317.
9. Frei K, Nohava K, Malipiero UV, Schwerdel C, Fontana A. 1992. Production of macrophage colon-stimulating factor by astrocytes and brain macrophages. J Neuroimmunol 40:189-196.
10. Giulian D. 1993. Reactive glia as rivals in regulating neuronal survival. Glia 7:102-110.
11. Giulian D, Vacam K, Corpuz M. 1993. Brain glia release factors with opposing actions upon neuronal survival. J Neurosci 13:29-37.
12. Kreutzberg GW. 1996. Microglia: a sensor for pathological events in the CNS. Trends Neurosci 19:312-318.
13. Kwiecien JM, O'Connor LT, Goetz BD, Delaney KH, Fletch AL, Duncan ID. 1998. Morphological and morphometric studies of the dysmyelinating mutant, the Long Evans Shaker rat. J Neurocytol 27:581-591.
14. Mallat M, Houlgatte R, Brachet P, Prochiantz A. 1989. Lipopolysaccharide-stimulated rat brain macrophages release NGF in vitro. Dev Biol 133:309-311.
15. McGeer PL, McGeer EG. 1995. The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases. Brain Res Rev 21:195-218.
16. Merrill JE, Ignarro LJ, Sherman MP, Melinek J, Lane TE. 1993. Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide. J Immunol 151:2132-2141.
17. Miller AD, Garcia JV, von Suhr N, Lynch CM, Wilson C, Eiden MV. 1991. Construction and properties of retrovirus packaging cells based on gibbon ape leukemia virus. J Virol 65:2220-2224.
18. Nakajima K, Honda S, Tohyama Y, Imai Y, Kohsaka S, Kurihara T. 2001. Neurotrophin secretion from cultured microglia. J Neurosci Res 65:322-331.
19. O'Connor LT, Goetz BD, Kwiecien JM, Delaney KH, Fletch AL, Duncan ID. 1999. Insertion of a retrotransposon in mbp disrupts mRNA splicing and myelination in a new mutant rat. J Neurosci 19:3404-3414.
20. Pocock JM, Liddle AC. 2001. Microglial signaling cascades in neurodegenerative disease. Prog Brain Res 132:555-565.
21. Popovic N, Schubart A, Goetz BD, Zhang S-C, Linington C, Duncan ID. 2002. Inhibition of autoimmune encephalomyelitis by a tetracycline. Ann Neurol 51:215-223.
22. Selkoe DJ. 1999. Translating cell biology into therapeutic advances in Alzheimer's disease. Nature 399(Suppl):A23-A31.
23. Stoll G, Jander S. 1999. The role of microglia and macrophages in the pathophysiology of the CNS. Prog Neurobiol 58:233-247.
24. Tikka TM. Koistinaho JE. 2001. Minocycline provides neuroprotection against N-methyl-D-aspartate neurotoxicity by inhibiting microglia. J Immunol 166:7527-7533.
25. Tikka T, Fiebich BL, Goldsteins G, Keinanen R, Koistinaho J. 2001. Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia. J Neurosci 21:2580-2588.
26. Wu DC, Jackson-Lewis V, Vila M, Tieu K, Teismann P, Vadseth C, Choi D-K, Ischiropoulos H, Przedborski S. 2002. Blockade of microglial activation is neuroprotective in the 1-methyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease. J Neurosci 22:1763-1771.
27. Yrjanheikki J, Keinanen R, Pellikka M, Hokfelt T, Koistinaho J. 1998. Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia. Proc Natl Acad Sci USA 95:15769-15774.
28. Yrjanheikki J, Tikka T, Keinanen R, Goldsteins G, Chan PH, Koistinaho J. 1999. A tetracycline derivate, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window. Proc Natl Acad Sci USA 96:13496-13500.
29. Zhang S-C, Fedoroff S. 1996. Neuron-microglia interaction in vitro. Acta Neuropathol 91:385-395.
30. Zhang S-C, Fedoroff S. 1998. Modulation of microglia by stem cell factor. J Neurosci Res 53:29-37.
31. Zhang S-C, Lundberg C, Lipsitz D, O'Connor LT, Duncan ID. 1998. Generation of oligodendroglial progenitors from neural stem cells. J Neurocytol 27:475-489.
32. Zhang S-C, Wagner D, Duncan ID. 1999. Acute death of grafted oligodendroglial progenitors. Soc Neurosci 25:215.
33. Zhang S-C, Goetz B, Carre J-L, Duncan ID. 2001. Reactive microglia in dysmyelination and demyelination. Glia 34:101-109.
34. Zhu S, Stavrovskaya IG, Drozda M, Kim BYS, Ona V, LM, Sarang S, Li M, Hartley DM, Wu DC, Gullans S, Ferrante RJ, Przedborski S, Kristal BS, Friedlander RM. 2002. Minocycline inhibits cytochrome C release and delays progression of amyotrophic lateral sclerosis in mice. Nature 417:74-78.