Coactivation of motoneurons regulated by a network combining electrical and chemical synapses

Journal of Neuroscience

Volumn 23, Issue 2, 2003, Pages 682-692

  Rela, Lorena ^a,b   Szczupak, Lidia ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b NONE   (Argentina)

Author keywords

Electrical rectification; Gap junctions; Leech; Motor control; Nonspiking; Rectifying electrical synapses

Indexed keywords

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL SYNCHRONIZATION; CONTROLLED STUDY; DEPOLARIZATION; EXCITATORY JUNCTION POTENTIAL; FEEDBACK SYSTEM; GANGLION; GAP JUNCTION; HYPERPOLARIZATION; INTERNEURON; LEECH; MEMBRANE POTENTIAL; MOLECULAR MECHANICS; MOTONEURON; NERVE CELL NETWORK; NERVE CONDUCTION; NERVE CORD; NEUROMODULATION; NEUROTRANSMISSION; NONHUMAN; POLYSYNAPTIC REFLEX; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SPIKE; SYNAPSE;

EID: 0037439749     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.23-02-00682.2003     Document Type: Article

References (40)

1. Acklin SE (1988) Electrical properties and anion permeability of doubly rectifying junctions in the leech central nervous system. J Exp Biol 137:1-11.
2. Alvarez VA, Chow CC, Van Bockstaele EJ, Williams JT (2002) Frequencydependent synchrony in locus ceruleus: role of electrotonic coupling. Proc Natl Acad Sci USA 99:4032-4036.
3. Beierlein M, Gibson JR, Connors BW (2000) A network of electrically coupled interneurons drives synchronized inhibition in neocortex. Nat Neurosci 3:904-910.
4. Bennett MV (1997) Gap junctions as electrical synapses. J Neurocytol 26:349-366.
5. Bennett MV, Barrio LC, Bargiello TA, Spray DC, Hertzberg E, Saez JC (1991) Gap junctions: new tools, new answers, new questions. Neuron 6:305-320.
6. Burrows M (1992) Local circuits for the control of leg movements in an insect. Trends Neurosci 15:226-232.
7. De Miguel FF, Vargas-Caballero M, Garcia-Perez E (2001) Spread of synaptic potentials through electrical synapses in Retzius neurones of the leech. J Exp Biol 204:3241-3250.
8. Dermietzel R (1998) Gap junction wiring: a "new" principle in cell-to-cell communication in the nervous system? Brain Res Brain Res Rev 26:176-183.
9. Edwards DH, Yeh SR, Krasne FB (1998) Neuronal coincidence detection by voltage-sensitive electrical synapses. Proc Natl Acad Sci USA 95:7145-7150.
10. Furshpan EJ, Potter DD (1959) Transmission at the giant motor synapses of the crayfish. J Physiol (Lond) 145:289-325.
11. Galarreta M, Hestrin S (1999) A network of fast-spiking cells in the neocortex connected by electrical synapses. Nature 402:72-75.
12. Galarreta M, Hestrin S (2001a) Electrical synapses between GABA-releasing interneurons. Nat Rev Neurosci 2:425-433.
13. Galarreta M, Hestrin S (2001b) Spike transmission and synchrony detection in networks of GABAergic interneurons. Science 292:2295-2299.
14. Gibson JR, Beierlein M, Connors BW (1999) Two networks of electrically coupled inhibitory neurons in neocortex. Nature 402:75-79.
15. Granzow B, Friesen WO, Kristan WB (1985) Physiological and morphological analysis of synaptic transmission between leech motor neurons. J Neurosci 5:2035-2050.
16. Graubard K, Hartline DK (1987) Full-wave rectification from a mixed electrical-chemical synapse. Science 237:535-537.
17. Hagiwara S, Morita H (1962) Electronic transmission between two nerve cells in leech ganglion. J Neurophysiol 25:721-731.
18. Iscla I, Arini PD, Szczupak L (1999) Differential channeling of sensory stimuli onto a motor neuron in the leech. J Comp Physiol 184:233-241.
19. Ishimaru M, Williams JT (1996) Synchronous activity in locus coeruleus results from dendritic interactions in pericoerulear regions. J Neurosci 16:5196-5204.
20. Kiehn O, Tresch MC (2002) Gap junctions and motor behavior. Trends Neurosci 25:108-115.
21. Koos T, Tepper JM (1999) Inhibitory control of neostriatal projection neurons by GABAergic interneurons. Nat Neurosci 2:467-472.
22. Landisman CE, Long MA, Beierlein M, Deans MR, Paul DL, Connors BW (2002) Electrical synapses in the thalamic reticular nucleus. J Neurosci 22:1002-1009.
23. Mann-Metzer P, Yarom Y (1999) Electrotonic coupling interacts with intrinsic properties to generate synchronized activity in cerebellar networks of inhibitory interneurons. J Neurosci 19:3298-3306.
24. Marin-Burgin A, Szczupak L (1998) A non-spiking interneuron regulates the sensory input onto the serotonergic neurons in the leech. Soc Neurosci Abstr 645:3.
25. Marin-Burgin A, Szczupak L (2000) Processing of sensory signals by a nonspiking neuron in the leech. J Comp Physiol [A] 186:989-997.
26. Muller KJ, Scott SA (1981) Transmission at a direct electrical connexion mediated by an interneurone in the leech. J Physiol (Lond) 311:565-583.
27. Muller KJ, Nicholls JG, Stent GS (1981) Neurobiology of the leech. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
28. Nicholls JG, Baylor DA (1968) Specific modalities and receptive fields of sensory neurons in CNS of the leech. J Neurophysiol 31:740-756.
29. Nicholls JG, Purves D (1970) Monosynaptic chemical and electrical connexions between sensory and motor cells in the central nervous system of the leech. J Physiol (Lond) 209:647-667.
30. Oh S, Rubin JB, Bennett MV, Verselis VK, Bargiello TA (1999) Molecular determinants of electrical rectification of single channel conductance in gap junctions formed by connexins 26 and 32. J Gen Physiol 114:339-364.
31. Peinado A, Yuste R, Katz LC (1993) Extensive dye coupling between rat neocortical neurons during the period of circuit formation. Neuron 10:103-114.
32. Schmitz D, Schuchmann S, Fisahn A, Draguhn A, Buhl EH, Petrasch-Parwez E, Dermietzel R, Heinemann U, Traub RD (2001) Axo-axonal coupling a novel mechanism for ultrafast neuronal communication. Neuron 31:831-840.
33. Shaw BK, Kristan WB (1995) The whole-body shortening reflex of the medicinal leech: motor pattern, sensory basis, and interneuronal pathways. J Comp Physiol [A] 177:667-681.
34. Stuart AE (1970) Physiological and morphological properties of motoneurones in the central nervous system of the leech. J Physiol (Lond) 209:627-646.
35. Szczupak L, Kristan WB (1995) Widespread mechanosensory activation of the serotonergic system of the medicinal leech. J Neurophysiol 74:2614-2623.
36. Tamás G, Buhl EH, Lörincz A, Somogyi P (2000) Proximally targeted GABAergic synapses and gap junctions synchronize cortical interneurons. Nat Neurosci 3:366-371.
37. Verselis VK, Ginter CS, Bargiello TA (1994) Opposite voltage gating polarities of two closely related connexins. Nature 368:348-351.
38. Wadepuhl M (1987) A morpho- and physiologically uncommon neuron in the leech CNS. Naturwissenschaften 74:43-45.
39. Wadepuhl M (1989) Depression of excitatory motoneurones by a single neurone in the leech central nervous system. J Exp Biol 143:509-527.
40. Wittenberg G, Kristan WB (1992) Analysis and modeling of the multisegmental coordination of shortening behavior in the medicinal leech. I. Motor output pattern. J Neurophysiol 68:1683-1707.