The yeast model for Batten disease: A role for Btn2p in the trafficking of the Golgi-associated vesicular targeting protein, Yif1p

Biochemical and Biophysical Research Communications

Volumn 302, Issue 3, 2003, Pages 534-538

  Chattopadhyay, Subrata ^a   Roberts, Paul M ^a   Pearce, David A ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

Batten disease; BTN1; BTN2; CLN3; Neurodegeneration; Neuronal ceroid lipofuscinosis; pH homeostasis; Protein trafficking; YIF1

Indexed keywords

PROTEIN; PROTEIN BTN2P; PROTEIN YIF1P; UNCLASSIFIED DRUG;

ARTICLE; CELL VACUOLE; ENDOPLASMIC RETICULUM; GENE DELETION; GOLGI COMPLEX; INTRACELLULAR MEMBRANE; NEURONAL CEROID LIPOFUSCINOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; SACCHAROMYCES CEREVISIAE;

GENETTA; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0037436836     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(03)00209-2     Document Type: Article

References (12)

1. Pearce D.A., Ferea T., Nosel S.A., Das B., Sherman F. Action of Btn1p, the yeast orthologue of the gene mutated in Batten disease. Nat. Genet. 22:1999;55-58.
2. Pearce D.A., Sherman F. BTN1, a yeast gene corresponding to the human gene responsible for Batten's disease, is not essential for viability, mitochondrial function, or degradation of mitochondrial ATP synthase. Yeast. 13:1997;691-697.
3. International Batten Disease Consortium. Isolation of a novel gene underlying Batten disease. Cell 82 (1995) 949-957.
4. Croopnick J.B., Choi H.C., Mueller D.M. The subcellular location of the yeast Saccharomyces cerevisiae homologue of the protein defective in juvenile form of Batten disease. Biochem. Biophys. Res. Commun. 250:1998;335-341.
5. Jarvela I., Sainio M., Rantamaki T., Olkkonen V.M., Carpen O., Peltonen L., Jalanko A. Biosynthesis and intracellular targeting of the CLN3 protein defective in Batten disease. Hum. Mol. Genet. 7:1998;85-90.
6. Chattopadhyay S., Muzzafar N.E., Sherman F., Pearce D.A. The yeast model for batten disease. btn1, btn2 or hsp30 mutation alter pH homeostasis. J. Bacteriol. 182:2000;6418-6423.
7. Chattopadhyay S., Pearce D.A. Interaction with Btn2p is required for localization of Rsg1p: Btn2p-mediated changes in arginine uptake in Saccharomyces cerevisiae. Euk. Cell. 1:2002;606-612.
8. Urano J., Tabancay A.P., Yang W., Tamanoi F. Rheb G-protein is involved in regulating canavanine resistance and arginine uptake. J. Biol. Chem. 275:2000;11198-11206.
9. Matern H., Yang X., Andrulis E., Sternglanz R., Trepte H.-H., Gallwitz D. A novel Golgi membrane protein is part of a GTPase-binding protein complex involved in vesicle targeting. EMBO J. 19:2000;4485-4492.
10. Calero M., Whittaker G.R., Collins R.N. Yop1p, the yeast homolog of the polyposis locus protein 1, interacts with Yip1p and negatively regulates cell growth. J. Biol. Chem. 276:2001;12100-12112.
11. Goebel H.H. The neuronal ceroid lipofuscinoses. J. Child. Neurol. 10:1995;424-437.
12. Wisniewski K.E., Kida E., Patxot O.F., Connel F. Variability in the clinical and pathological findings in the neuronal ceroid lipofuscinoses: review of data and observations. Am. J. Med. Genet. 42:1992;525-532.