Design and characterization of a hyperstable p16INK4a that restores Cdk4 binding activity when combined with oncogenic mutations

Journal of Molecular Biology

Volumn 327, Issue 1, 2003, Pages 285-297

  Cammett, Tobin J ^a   Luo, Li ^a   Peng, Zheng Yu ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

Cancer related mutations; Cyclin dependent kinase inhibitor; p16INK4a; Protein design; Stability

Indexed keywords

CYCLIN DEPENDENT KINASE 4; MONOMER; PROTEIN P16;

AMINO ACID SUBSTITUTION; ARTICLE; CARCINOMA; CONTROLLED STUDY; GENE MUTATION; HYDROPHOBICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEIN FUNCTION; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; PROTEIN TERTIARY STRUCTURE; SURFACE PROPERTY; THERMOSTABILITY;

MAMMALIA;

EID: 0037436385     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2836(03)00043-3     Document Type: Article

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