Effects of exogenous creatine on population spike amplitude and on postanoxic hyperexcitability in brain slices

Brain Research

Volumn 963, Issue 1-2, 2003, Pages 197-202

  Parodi, Monica ^a   Rebaudo, Renata ^a   Perasso, Luisa ^a   Gandolfo, Carlo ^a   Cupello, Aroldo ^b   Balestrino, Maurizio ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b CNR   (Italy)

Author keywords

Anoxia; Brain; Creatine; Hyperexcitability; Ischemia; Neuron; Stroke

Indexed keywords

CREATININE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN HYPOXIA; BRAIN SLICE; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; FEMALE; HIPPOCAMPUS; IN VITRO STUDY; NERVE CELL LESION; NEUROPROTECTION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; SEIZURE;

ACTION POTENTIALS; ANIMALS; BRAIN; CREATINE; ELECTROPHYSIOLOGY; FEMALE; HIPPOCAMPUS; HYPOXIA, BRAIN; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0037435871     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(02)03976-8     Document Type: Article

References (19)

1. Balestrino M., Rebaudo R., Lunardi G. Exogenous creatine delays anoxic depolarization and protects from hypoxic damage: dose-effect relationship. Brain Res. 816:1999;124-130.
2. Bliss T.V., Collingridge G.L. A synaptic model of memory: long-term potentiation in the hippocampus. Nature. 361:1993;31-39.
3. Carter A.J., Muller R.E., Pschorn U., Stransky W. Preincubation with creatine enhances levels of creatine phosphate and prevents anoxic damage in rat hippocampal slices. J. Neurochem. 64:1995;2691-2699.
4. Clarke D.D., Sokoloff L. Circulation and energy metabolism of the brain. Siegel G.J., Agranoff B.W., Wayne Albers R., Fisher S.K., Uhler M.D. Basic Neurochemistry. 1999;638-669 Lippincott Wiliams and Wilkins, Philadelphia, PA.
5. Di Loreto S., Balestrino M. Development of vulnerability to hypoxic damage in in vitro hippocampal neurons. Int. J. Dev. Neurosci. 15:1997;225-230.
6. Giroud M., Gras P., Fayolle H., Andre N., Soichot P., Dumas R. Early seizures after acute stroke: a study of 1640 cases. Epilepsia. 35:1994;959-964.
7. Hammond C., Crepel V., Gozlan H., Ben-Ari Y. Anoxic LTP sheds light on the multiple facets of NMDA receptors. Trends Neurosci. 17:1994;497-503.
8. Hsu K.S., Huang C.C. Characterization of the anoxia-induced long-term synaptic potentiation in area CA1 of the rat hippocampus. Br. J. Pharmacol. 122:1997;671-681.
9. Kass I.R., Lipton P. Mechanisms involved in irreversible anoxic damage to the in vitro rat hippocampal slice. J. Physiol. (Lond.). 332:1982;459-472.
10. 3H]flunitrazepam binding. Soc. Neurosci. Abstr. (2001) Abstract 700.8.
11. Kilpatrick C.J., Davis S.M., Tress B.M., Rossiter S.C., Hopper J.L., Vandendriesen M.L. Epileptic seizures in acute stroke. Arch. Neurol. 47:1990;157-160.
12. Lo Y.K., Yiu C.H., Hu H.H., Su M.S., Laeuchli S.C. Frequency and characteristics of early seizures in Chinese acute stroke. Acta Neurol. Scand. 90:1994;83-85.
13. McEachern J.C., Shaw C.A. The plasticity-pathology continuum: defining a role for the LTP phenomenon. J. Neurosci. Res. 58:1999;42-61.
14. Melani R., Rebaudo R., Balestrino M., Cupello A., Haglid K., Hyden H. Involvement of S-100 protein in anoxic long-term potentiation. Brain Res. 840:1999;171-174.
15. Reith J., Jorgensen H.S., Nakayama H., Raaschou H.O., Olsen T.S. Seizures in acute stroke: Predictors and prognostic significance - The Copenhagen Stroke Study. Stroke. 28:1997;1585-1589.
16. Schiff S.J., Somjen G.G. Hyperexcitability following moderate hypoxia in hippocampal tissue slices. Brain Res. 337:1985;337-340.
17. Schiff S.J., Somjen G.G. The effect of graded hypoxia on the hippocampal slice: an in vitro model of the ischemic penumbra. Stroke. 18:1987;30-37.
18. Somjen G.G., Aitken P.G., Balestrino M., Herreras O., Kawasaki K. Spreading depression-like depolarization and selective vulnerability of neurons. A brief review. Stroke. 21:1990;III179-III183.
19. Whittingham T.S., Lipton P. Cerebral synaptic transmission during anoxia is protected by creatine. J. Neurochem. 37:1981;1618-1621.