Mycobacterium tuberculosis ketopantoate hydroxymethyltransferase: Tetrahydrofolate-independent hydroxymethyltransferase and enolization reactions with α-Keto acids

Biochemistry

Volumn 42, Issue 1, 2003, Pages 191-199

  Sugantino, Michele ^a   Zheng, Renjian ^a   Yu, Michael ^a   Blanchard, John S ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENOLIZATION REACTIONS;

BACTERIA; IONIZATION; ISOTOPES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ORGANIC ACIDS; PH EFFECTS; STEREOCHEMISTRY; SUBSTRATES;

ENZYMES;

2 OXOACID; 2 OXOBUTYRIC ACID; 2 OXOISOVALERIC ACID; 2 OXOPANTOATE HYDROXYMETHYLTRANSFERASE; CALCIUM ION; COBALT; DEUTERIUM; FORMALDEHYDE; HYDROGEN; MAGNESIUM ION; METAL ION; METHYLENETETRAHYDROFOLIC ACID; METHYLTRANSFERASE; NICKEL; PYRUVIC ACID; TETRAHYDROFOLIC ACID; UNCLASSIFIED DRUG; ZINC ION;

ALKALINITY; ARTICLE; ATOM; CATALYSIS; CATALYST; CHEMICAL REACTION; ENOLIZATION; ENZYME ACTIVE SITE; ENZYME PURIFICATION; IONIZATION; MOLECULAR CLONING; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; REACTION TIME; STEREOCHEMISTRY; STEREOSPECIFICITY;

AMINO ACIDS; BACTERIAL PROTEINS; CATALYSIS; DEUTERIUM; ENZYME ACTIVATION; HYDROGEN-ION CONCENTRATION; HYDROXYMETHYL AND FORMYL TRANSFERASES; KETO ACIDS; METALS; MOLECULAR CONFORMATION; MYCOBACTERIUM TUBERCULOSIS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PANTOTHENIC ACID; PROTONS; PYRUVIC ACID; RECOMBINANT PROTEINS; SPECTROPHOTOMETRY; SUBSTRATE SPECIFICITY; TETRAHYDROFOLATES;

ACTINOBACTERIA (CLASS); MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS; PROKARYOTA; UNCULTURED ACTINOMYCETE;

EID: 0037435596     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi020516q     Document Type: Article

References (19)

1. Maas, W. K., and Davis, B. D. (1950) J. Bacteriol. 60, 733-745.
2. Maas, W. K., and Vogel, H. J. (1953) J. Bacteriol. 65, 388-393.
3. Brown, G. M., and Williamson, J. M. (1982) Adv. Enzymol. 53, 345-381.
4. Teller, H. T., Powers, S. G., and Snell, E. E. (1976) J. Biol. Chem. 251, 3780-3785.
5. Powers, S. G., and Snell, E. E. (1976) J. Biol. Chem. 251, 3786-3793.
6. Jones, C. E., Brook, J. M., Buck, D., Abell, C., and Smith, A. (1993) J. Bacteriol. 175, 2125-2130.
7. Kurtov, D., Kinghorn, J. R., and Unkles, S. E. (1999) MoL Gen. Genet. 262, 115-120.
8. Downs, D. M., and Roth, J. R. (1991) J. Bacteriol. 173, 6597- 6604.
9. Cronan, J. E., Jr., Littel, K. J., and Jackowski, S. (1982) J. Bacteriol. 149, 916-922.
10. Jackowski, S., and Rock, C. O. (1981) J. Bacteriol. 148, 926-932.
11. Rubio, A., and Downs, D. M.(2002) J. Bacteriol. 184, 2827- 2832.
12. Angelaccio, S., Pascarella, S., Fattori, E., Bossa, F., Strong, W., and Schirch, V. (1992) Biochemistry 31, 155-162.
13. Stover, P., Zamora, M., Shostak, K., Gautam-Basak, M., and Schirch, V. (1992) J. Biol. Chem. 267, 17679-17687.
14. Schrich, D., Delle Fratte, S., Iurescia, S., Angelaccio, S., Contestabile, R., Bossa, F., and Schirch, V. (1993) J. Biol. Chem. 268, 23132-23138.
15. Scarsdale, J. N., Radaev, S., Kazanina, G., Schirch, V., and Wright, H. T. (2000) J. Biol. Chem. 296, 155-168.
16. Contestabile, R., Angelaccio, S., Bossa, F., Wright, H. T., Scarsdale, J. N., Kazanina, G., and Schirch, V. (2000) Biochemistry 39, 7492-7500.
17. Oba, M., Kobayashi, M., Oikawa, F., and Nishiyama, K. (2001) J. Org. Chem. 66, 5919-5922.
18. Neidhardt, F. (1996) Escherichia coli and Salmonella typhimurium: cellular and molecular biology, pp 687-694, American Society for Microbiology, Washington, DC.
19. Cole, S. T., Brosch, R., Parkhill, J., Garnier, T., Chucher, C., Harris, D., Gordon, S. V., Eilmeierk, K., et al. (1998) Nature 55, 416-421.