Characterization of the inhibition of pyruvate kinase caused by phenylalanine and phenylpyruvate in rat brain cortex

Brain Research

Volumn 968, Issue 2, 2003, Pages 199-205

  Feksa, Luciane Rosa ^a   Cornelio, Andrea Renata ^a   Dutra Filho, Carlos Severo ^a   Wyse, Angela Terezinha De Souza ^a   Wajner, Moacir ^a   Wannmacher, Clóvis Milton Duval ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Alanine; Phenylalanine; Phenylketonuria; Phenylpyruvate; Pyruvate kinase

Indexed keywords

ADENOSINE DIPHOSPHATE; ALANINE; CARBOHYDRATE; GLUCOSE; PHENYLALANINE; PHENYLPYRUVIC ACID; PHOSPHOENOLPYRUVATE; PYRUVATE KINASE;

ALLOSTERISM; ANIMAL TISSUE; ARTICLE; BINDING COMPETITION; BRAIN CORTEX; BRAIN HOMOGENATE; CONTROLLED STUDY; DIET SUPPLEMENTATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME SUBSTRATE COMPLEX; GLUCOSE METABOLISM; MITOCHONDRION; NEUROLOGIC DISEASE; NONHUMAN; PATHOPHYSIOLOGY; PHENYLKETONURIA; PRIORITY JOURNAL; RAT;

EID: 0037432556     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(03)02239-X     Document Type: Article

References (28)

1. Berman P.W., Graham F.K., Eichman P.L., Waisman H.A. Psychologic and neurologic status of diet-treated phenylketonuric children and their siblings. Pediatrics. 28:1961;924-934.
2. Cespedes C., Thoene J.G., Lower K., Christensen H.N. Evidence of inhibition of exodus of small neutral amino acids from non-brain tissues in hyperphenylalaninemic rats. J. Inherit. Metab. Dis. 12:1989;166-180.
3. Chainy G.B.N., Kanungo M.S. Induction and properties of pyruvate kinase of the cerebral hemisphere of rats of various ages. J. Neurochem. 30:1978;419-427.
4. Chevillard C., Cárdenas M.L., Cornish-Bowden A. The competition plot: a sample test of whether two relations occur at the same active site. J. Biochem. 289:1993;599-604.
5. 1 from the pig brain. Int. J. Biochem. Cell Biol. 27:1995;1145-1151.
6. Fish R.O., Walker W.A., Anderson J.A. Prenatal and postnatal developmental consequences of maternal phenylketonuria. Pediatrics. 37:1966;979-986.
7. Fish R.O., Torres F., Graven H.J., Greenwood C.S., Anderson J.A. Twelve years of clinical experience with phenylketonuria. Neurology (Minneap). 19:1969;659-666.
8. Gimenez C., Valdivieso F., Major F. Glycolysis in the brain and liver of rats with experimentally induced phenylketonuria. Biochem. Med. 11:1974;81-86.
9. Glazer R.I., Weber G. The effects of L-phenylalanine and phenylpyruvate on glycolysis in rat cerebral cortex. Brain Res. 33:1971;439-450.
10. Hall E.R., Cottam G.L. Isoenzymes of pyruvate kinase in vertebrates: their physical, chemical, kinetic and immunological properties. Int. J. Biochem. 9:1978;785-793.
11. Hasselbach S., Knudsen G.M., Toft P.B., Hogh P., Tedeschi E., Holm S., Videbaek C., Henriksen O., Lou H.C., Paulson O.B. Cerebral glucose metabolism is decreased in white matter changes in patients with phenylketonuria. Pediatr. Res. 40:1996;21-24.
12. Ibsen K.H., Marles S.W. Inhibition of chicken pyruvate kinases by amino acids. Biochemistry. 15:1976;1073-1079.
13. Kayne F.J., Price N.C. Conformational changes in the allosteric inhibition of muscle pyruvate kinase by phenylalanine. Biochemistry. 11:1972;4415-4420.
14. Kayne F.J., Price N.C. Amino acid effector binding to rabbit muscle pyruvate kinase. Arch. Biochem. Biophys. 159:1973;292-296.
15. Leong S.F., Lai J.C.K., Lim L., Clark J.B. Energy-metabolising enzymes in brain regions of adult and aging rats. J. Neurochem. 37:1981;1548-1556.
16. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
17. Mattevi A., Bolognesi M., Valentini G. The allosteric regulation of pyruvate kinase. FEBS Lett. 389:1996;15-19.
18. Miller A.L., Hawkins R.A., Veech R.L. Phenylketonuria: phenylalanine inhibits brain pyruvate kinase in vivo. Science. 179:1973;904-906.
19. Rodrigues N.R., Wannmacher C.M.D., Dutra-Filho C.S., Pires R.F., Fagan P.R., Wajner M. Effect of phenylalanine, p-chlorophenylalanine and α-methylphenylalanine on glucose uptake in vitro by the brain of young rats. Biochem. Soc. Trans. 18:1990;419.
20. Rozengurt E., Jiménez de Asúa L., Carminatti H. Allosteric Inhibition of Muscle Pyruvate Kinase By Phenylalanine. Vol. 11:1970;284-286 North-Holland Publishing Company, Amsterdam.
21. Schwark W.S., Singhal R.L., Ling G.M. Regulation of pyruvate kinase in the rat cerebral cortex. J. Neurochem. 18:1971;123-134.
22. Scriver C.R., Kaufman S. Hyperphenylalaninemia: phenylalanine hydroxylase deficiency. Scriver C.R., Beaudet A.L., Sly W.S., Valle D. The Metabolic and Molecular Bases of Inherited Diseases. 8th Edition: 2001;1667-1724 McGraw-Hill, New York.
23. 14C-labelled glucose into total lipids. J. Neurochem. 17:1970;279-284.
24. Srivastava L.K., Baquer N.Z. Purification and properties of rat brain pyruvate kinase. Arch. Biochem. Biophys. 236:1985;703-713.
25. 1 from bovine brain. Int. J. Biochem. 21:1989;1053-1060.
26. Vijayvargiya R., Schwark W.S., Singhal R.L. Pyruvate kinase: modulation by L-henylalanine and L-alanine. Can. J. Biochem. 47:1969;895-898.
27. Weber G., Glazer R.I., Ross R.A. Regulation of human and rat brain metabolism: Inhibitory action of phenylalanine and phenylpyruvate on glycolysis, protein, lipid, DNA and RNA metabolism. Adv. Enzyme Regul. 8:1970;13-36.
28. +-ATPase activity by phenylalanine and phenyllactate in the synaptic plasma membrane from the cerebral cortex of rats. Med. Sci. Res. 26:1998;141-143.