Proerectile effects of apomorphine in mice

Life Sciences

Volumn 72, Issue 21, 2003, Pages 2329-2336

  Rampin, Olivier ^a   Jérôme, Nathalie ^a   Suaudeau, Charles ^b  

^a CEMAGREF   (France)

^b UNIVERSITÉ DE ROUEN   (France)

Author keywords

D2 receptors; Dopamine; Genital tract; Sex behavior

Indexed keywords

APOMORPHINE; DOMPERIDONE; DOPAMINE 2 RECEPTOR; DOPAMINE 2 RECEPTOR BLOCKING AGENT; HALOPERIDOL;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; GENITAL SYSTEM; GROOMING; MALE; MOUSE; NONHUMAN; PENIS ERECTION; SEXUAL BEHAVIOR;

EID: 0037432497     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(03)00122-X     Document Type: Article

References (23)

1. Andersson K.E., Wagner G. Physiology of penile erection. Physiological Reviews. 75:1995;191-236.
2. Benassi-Benelli A., Ferrari F., Pellegrini-Quarantotti B. Penile erection induced by apomorphine and N-n-propyl-norapomorphine in rats. Archives Internationales de Pharmacodynamie et de Thérapeutique. 242:1979;241-247.
3. Burnett A.L., Nelson R.J., Calvin D.C., Liu J.X., Demas G.E., Klein S.L., Kriegsfeld L.J., Dawson V.L., Dawson T.M., Snyder S.H. Nitric oxide-dependent penile erection in mice lacking neuronal nitric oxide synthase. Molecular Medicine. 2:1996;288-296.
4. Drago J., Padungchaichot P., Accili D., Fuchs S. Dopamine receptors and dopamine transporter in brain function and addictive behaviors: insights from targeted mouse mutants. Developmental Neuroscience. 20:1998;188-203.
5. Gonzalez-Rios F., Vlaiculescu A., Ben Natan L., Protais P., Costentin J. Dissociated effects of apomorphine on various nociceptive responses in mice. Journal of Neural Transmission. 67:1986;87-103.
6. Heaton J.P.W., Varrin S.J., Morales A. The characterization of a bio-assay of erectile function in a rat model. Journal of Urology. 145:1991;1099-1102.
7. Heaton J.P.W., Dean J., Sleep D.J. Sequential administration enhances the effects of apomorphine SL in men with erectile dysfunction. International Journal of Impotence Research. 14:2002;61-64.
8. Hedlund P., Aszodi A., Pfeifer A., Alm P., Hofman F., Ahmad M., Fässler R., Andersson K.E. Erectile dysfunction in cyclic GMP-dependent kinase I-deficient mice. Proceedings of the National Academy of Sciences. 97:2000;2349-2354.
9. Ladurelle N., Duterte-Boucher D., Costentin J. Stimulation of D1 and D2 dopamine receptors produces additive anorectic effects. Fundamental and Clinical Pharmacology. 5:1991;481-490.
10. Lal S., Ackman D., Thavundayil J.X., Kiely M.E., Etienne P. Effect of apomorphine, a dopamine receptor agonist, on penile tumescence in normal subjects. Progress in Neuropsychopharmacology and Biological Psychiatry. 8:1984;695-699.
11. Melis M.R., Argiolas A., Gessa G.L. Apomorphine-induced penile erection and yawning: site of action in the brain. Brain Research. 415:1987;98-104.
12. Melis M.R., Argiolas A. Dopamine and sexual behavior. Neuroscience and Biobehavioral Reviews. 19:1995;19-38.
13. Missale C., Nash S.R., Robinson S.W., Jaber M., Caron M.G. Dopamine receptors: from structure to function. Physiological Reviews. 78:1998;189-225.
14. Mulhall J.P. Sublingual apomorphine for the treatment of erectile dysfunction. Expert Opinion in Investigational Drugs. 11:2002;295-302.
15. Pomerantz S.M. Apomorphine facilitates male sexual behavior of rhesus monkeys. Pharmacology Biochemistry and Behavior. 35:1990;659-664.
16. Protais P., Costentin J., Schwartz J.C. Climbing behaviour induced by apomorphine in mice: A simple test for the study of dopamine receptors in striatum. Psychopharmacology. 50:1976;1-6.
17. Sachs B.D. Sexual reflexes of spinal male house mice. Physiology and Behavior. 24:1980;489-492.
18. Sachs B.D., Akasofu K., McEldowney S.S. Effects of copulation on apomorphine-induced erection in rats. Pharmacology Biochemistry and Behavior. 48:1994;423-428.
19. Sachs B.D. Contextual approaches to the physiology and classification of erectile function, erectile dysfunction, and sexual arousal. Neuroscience and Biobehavioral Reviews. 24:2000;541-560.
20. Schmidt M.H., Schmidt H.S. The ischiocavernosus and bulbospongiosus muscles in mammalian penile rigidity. Sleep. 16:1993;171-183.
21. Sezen S.F., Burnett A.L. Intracavernosal pressure monitoring in mice: responses to electrical stimulation of the cavernous nerve and to intracavernosal drug administration. Journal of Andrology. 21:2000;311-315.
22. Zarrindast M.R., Shokravi S., Samini M. Opposite influence of dopaminergic receptor subtypes on penile erection. General Pharmacology. 23:1992;671-675.
23. Zhou Q.Y., Palmiter R.D. Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic. Cell. 83:1995;1197-1209.