Characterization of transcripts generated from mouse hepatocyte growth factor activator inhibitor type 2 (HAI-2) and HAI-2-related small peptide (H2RSP) genes: Chimeric mRNA transcribed from both HAI-2 and H2RSP genes is detected in human but not in mouse

Biochemical and Biophysical Research Communications

Volumn 302, Issue 2, 2003, Pages 345-353

  Naganuma, Seiji ^a   Itoh, Hiroshi ^a   Uchiyama, Shuichiro ^a   Tanaka, Hiroyuki ^a   Nagaike, Koki ^a   Miyata, Shiro ^a   Uchinokura, Shunro ^a   Nuki, Yoshitsugu ^a   Akiyama, Yutaka ^a   Chijiiwa, Kazuo ^a   Kataoka, Hiroaki ^a  

^a UNIVERSITY OF MIYAZAKI   (Japan)

Author keywords

Chimeric mRNA; H2RSP; HGF; HGF activator inhibitor; Mouse gene; Nuclear localization signal

Indexed keywords

GENE PRODUCT; HEPATOCYTE GROWTH FACTOR ACTIVATOR INHIBITOR TYPE 2; HEPATOCYTE GROWTH FACTOR ACTIVATOR INHIBITOR TYPE 2 RELATED SMALL PEPTIDE; LYSINE; MESSENGER RNA; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CHIMERA; EXON; GASTROINTESTINAL TRACT; GENE FUNCTION; GENE LOCATION; GENETIC ANALYSIS; GENETIC CONSERVATION; GENETIC STRAIN; HUMAN; HUMAN CELL; KIDNEY; MOLECULAR CLONING; MOUSE; NONHUMAN; NORTHERN BLOTTING; NUCLEAR LOCALIZATION SIGNAL; NUCLEOTIDE SEQUENCE; PLACENTA; PRIORITY JOURNAL; PROMOTER REGION; PROSTATE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SPLICING; RNA TRANSCRIPTION; SPECIES COMPARISON; TRANSCRIPTION INITIATION;

EID: 0037428254     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(03)00154-2     Document Type: Article

References (30)

1. Itoh H., Kataoka H., Yamauchi M., Naganuma S., Akiyama Y., Nuki Y., Shimomura T., Miyazawa K., Kitamura N., Koono M. Identification of hepatocyte growth factor activator inhibitor type 2 (HAI-2)-related small peptide (H2RSP): Its nuclear localization and generation of chimeric mRNA transcribed from both HAI-2 and H2RSP genes. Biochem. Biophys. Res. Commun. 288:2001;390-399.
2. Itoh H., Yamauchi M., Kataoka H., Hamasuna R., Kitamura N., Koono M. Genomic structure and chromosomal localization of the human hepatocyte growth factor activator inhibitor type 1 and 2 genes. Eur. J. Biochem. 267:2000;3351-3359.
3. Kawaguchi T., Qin L., Shimomura T., Kondo J., Matsumoto K., Denda K., Kitamura N. Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor. J. Biol. Chem. 272:1997;27558-27564.
4. Marlor C.W., Delaria K.A., Davis G., Muller D.K., Greve J.M., Tamburini P.P. Identification and cloning of human placental bikunin, a novel serine protease inhibitor containing two Kunitz domains. J. Biol. Chem. 272:1997;12202-12208.
5. Itoh H., Kataoka H., Hamasuna R., Kitamura N., Koono M. Hepatocyte growth factor activator inhibitor type 2 lacking the first Kunitz-type serine proteinase inhibitor domain is a predominant product in mouse but not in human. Biochem. Biophys. Res. Commun. 255:1999;740-748.
6. Itoh H., Ide H., Ishikawa N., Nawa Y. Mast cell protease inhibitor, trypstatin, is a fragment of inter-α-trypsin inhibitor light chain. J. Biol. Chem. 269:1994;3818-3822.
7. Kozak M. The scanning model for translation: an update. J. Cell Biol. 108:1989;229-241.
8. Ozanne B.W., McGarry L., Spence H.J., Johnston I., Winnie J., Meagher L., Stapleton G. AP-1 regulation of a multigenic invasion programme. Eur. J. Cancer. 36:2000;1640-1648.
9. Yordy J.S., Muise-Helmericks R.C. Signal transduction and the Ets family of transcription factors. Oncogene. 19:2000;6503-6513.
10. Lennon G., Auffray C., Polymeropoulos M., Soares M.B. The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression. Genomics. 33:1996;151-152.
11. Jans D.A. The regulation of protein transport to the nucleus by phosphorylation. Biochem. J. 311:1995;705-716.
12. Shibasaki F., Price E.R., Milan D., McKeon F. Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4. Nature. 382:1996;370-373.
13. Nigg E.A. Nucleocytoplasmic transport: signals, mechanisms and regulation. Nature. 386:1997;779-787.
14. Mattaj I.W., Englmeier L. Nucleocytoplasmic transport: the soluble phase. Annu. Rev. Biochem. 67:1998;265-306.
15. Itoh H., Kataoka H., Meng J.Y., Hamasuna R., Kitamura N., Koono M. Mouse hepatocyte growth factor activator inhibitor type 1 (HAI-1) and type 2 (HAI-2)/placental bikunin genes and their promoters. Biochim. Biophys. Acta. 1519:2001;92-95.
16. Yamauchi M., Itoh H., Naganuma S., Koono M., Hasui Y., Osada Y., Kataoka H. Expression of hepatocyte growth factor activator inhibitor type 2 (HAI-2) in human testis: identification of a distinct transcription start site for the HAI-2 gene in testis. Biol. Chem. 383:2002;1953-1957.
17. Kim J.K., Ryll R., Ishizuka Y., Kato S. Identification of cDNAs encoding two novel nuclear proteins, IMUP-1 and IMUP-2, upregulated in SV40-immortalized human fibroblasts. Gene. 257:2000;327-334.
18. Annilo T., Karis A., Hoth S., Rikk T., Kruppa J., Metspalu A. Nuclear import and nucleolar accumulation of the human ribosomal protein S7 depends on both a minimal nuclear localization sequence and an adjacent basic region. Biochem. Biophys. Res. Commun. 249:1998;759-766.
19. Ueki N., Kondo M., Seki N., Yano K., Oda T., Masuho Y., Muramatsu M. NOLP: identification of a novel human nucleolar protein and determination of sequence requirements for its nucleolar localization. Biochem. Biophys. Res. Commun. 252:1998;97-102.
20. Valdez B.C., Perlaky L., Henning D., Saijo Y., Chan P.K., Busch H. Identification of the nuclear and nucleolar localization signals of the protein p120. Interaction with translocation protein B23. J. Biol. Chem. 269:1994;23776-23783.
21. Mo Y.Y., Wang C., Beck W.T. A novel nuclear localization signal in human DNA topoisomerase I. J. Biol. Chem. 275:2000;41107-41113.
22. Srivastava M., Pollard H.B. Molecular dissection of nucleolin's role in growth and cell proliferation: new insights. FASEB J. 13:1999;1911-1922.
23. Scheer U., Weisenberger D. The nucleolus. Curr. Opin. Cell Biol. 6:1994;354-359.
24. Shimomura T., Denda K., Kitamura A., Kawaguchi T., Kito M., Kondo J., Kagaya S., Qin L., Takata H., Miyazawa K., Kitamura N. Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor. J. Biol. Chem. 272:1997;6370-6376.
25. Kataoka H., Suganuma T., Shimomura T., Itoh H., Denda K., Kitamura N., Nabeshima K., Koono M. Distribution of hepatocyte growth factor activator inhibitor type 1 (HAI-1) in human tissues: cellular surface localization of HAI-1 in simple columnar epithelium and its modulated expression in injured and regenerative tissues. J. Histochem. Cytochem. 47:1999;673-682.
26. Kataoka H., Shimomura T., Kawaguchi T., Hamasuna R., Itoh H., Kitamura N., Miyazawa K., Koono M. Hepatocyte growth factor activator inhibitor type 1 is a specific cell surface binding protein of hepatocyte growth factor activator (HGFA) and regulates HGFA activity in the pericellular microenvironment. J. Biol. Chem. 275:2000;40453-40462.
27. Kataoka H., Itoh H., Nuki Y., Hamasuna R., Naganuma S., Kitamura N., Shimomura T. Mouse hepatocyte growth factor (HGF) activator inhibitor type 2 lacking the first Kunitz domain potently inhibits the HGF activator. Biochem. Biophys. Res. Commun. 290:2002;1096-1100.
28. Itoh H., Kataoka H., Tomita M., Hamasuna R., Nawa Y., Kitamura N., Koono M. Up-regulation of hepatocyte growth factor activator inhibitor type-1 but not type-2 along with regeneration of intestinal mucosa. Am. J. Phys. 278:2000;G635-G643.
29. Hamasuna R., Kataoka H., Meng J.Y., Itoh H., Moriyama T., Wakisaka S., Koono M. Reduced expression of hepatocyte growth factor activator inhibitor type-2/placental bikunin (HAI-2/PB) in human glioblastomas: implication for anti-invasive role of HAI-2/PB in glioblastoma cells. Int. J. Cancer. 93:2001;339-345.
30. Mitchell K.J., Pinson K.I., Kelly O.G., Brennan J., Zupicich J., Scherz P., Leighton P.A., Goodrich L.V., Lu X., Avery B.J., tate P., Dill K., Pangilinan E., Wakenight P., Tessier-Lavigne M., Skarnes W.C. Functional analysis of secreted and transmembrane proteins critical to mouse development. Nat. Genet. 28:2001;241-249.