Caenorhabditis elegans innate immune response triggered by Salmonella enterica requires intact LPS and is mediated by a MAPK signaling pathway

Current Biology

Volumn 13, Issue 1, 2003, Pages 47-52

  Aballay, Alejandro ^a,b   Drenkard, Eliana ^a   Hilbun, Layla R ^b   Ausubel, Frederick M ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS REGULATORY PROTEIN; BACTERIAL PROTEIN; CAENORHABDITIS ELEGANS PROTEIN; CED 9 PROTEIN, C ELEGANS; CED-9 PROTEIN, C ELEGANS; ESCHERICHIA COLI PROTEIN; ISOMERASE; LIGASE; LIPOPOLYSACCHARIDE; LPCA PROTEIN, E COLI; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; NERVE PROTEIN; ONCOPROTEIN; PMK 1 PROTEIN, C ELEGANS; PMK-1 PROTEIN, C ELEGANS; RFAL PROTEIN, E COLI; TOL 1 PROTEIN, C ELEGANS; TOL-1 PROTEIN, C ELEGANS;

ANIMAL; ARTICLE; CAENORHABDITIS ELEGANS; CELL DEATH; GENETICS; IMMUNE SYSTEM; IMMUNOLOGY; METABOLISM; MICROBIOLOGY; MUTATION; PHYSIOLOGY; SALMONELLA ENTERICA; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; BACTERIAL PROTEINS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CELL DEATH; ESCHERICHIA COLI PROTEINS; IMMUNE SYSTEM; LIGASES; LIPOPOLYSACCHARIDES; MAP KINASE SIGNALING SYSTEM; MEMBRANE PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MUTATION; NERVE TISSUE PROTEINS; PROTO-ONCOGENE PROTEINS; RACEMASES AND EPIMERASES; SALMONELLA ENTERICA;

ANIMALIA; BACTERIA (MICROORGANISMS); CAENORHABDITIS; CAENORHABDITIS ELEGANS; HEXAPODA; MAMMALIA; SALMONELLA; SALMONELLA ENTERICA;

EID: 0037425599     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(02)01396-9     Document Type: Article

References (31)

1. Aballay, A., Yorgey, P., and Ausubel, F.M. (2000). Salmonella typhimurium proliferates and establishes a persistent infection in the intestine of Caenorhabditis elegans. Curr. Biol, 10, 1539-1542.
2. Labrousse, A., Chauvet, S., Couillault, C., Kurz, C.L., and Ewbank, J.J. (2000). Caenorhabditis elegans is a model host for Salmonella typhimurium. Curr. Biol. 10, 1543-1545.
3. Aballay, A., and Ausubel, F.M. (2001). Programmed cell death mediated by ced-3 and ced-4 protects Caenorhabditis elegans from Salmonella typhimurium-mediated killing. Proc. Natl. Acad. Sci. USA 98, 2735-2739.
4. Mallo, G.V., Kurz, C.L., Couillault, C., Pujol, N., Granjeaud, S., Kohara, Y., and Ewbank, J.J. (2002). Inducible antibacterial defense system in C. elegans. Curr. Biol. 12, 1209-1214.
5. Kim, D.H., Feinbaum, R., Alloing, G., Emerson, F.E., Garsin, D.A., Inoue, H., Tanaka-Hino, M., Hisamoto, N., Matsumoto, K., Tan, M.W., et al. (2002). A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity. Science 297, 623-626.
6. Rouse, J., Cohen, P., Trigon, S., Morange, M., Alonso-Llamazares, A., Zamanillo, D., Hunt, T., and Nebreda, A.R. (1994). A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell 78, 1027-1037.
7. Freshney, N.W., Rawlinson, L., Guesdon, F., Jones, E., Cowley, S., Hsuan, J., and Saklatvala, J. (1994). Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27. Cell 78, 1039-1049.
8. Han, J., Lee, J.D., Bibbs, L., and Ulevitch, R.J. (1994). A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265, 808-811.
9. Gartner, A., Milstein, S., Ahmed, S., Hodgkin, J., and Hengartner, M.O. (2000). A conserved checkpoint pathway mediates DNA damage-induced apoptosis and cell cycle arrest in C. elegans. Mol. Cell 5, 435-443.
10. Sagasti, A., Hisamoto, N., Hyodo, J., Tanaka-Hino, M., Matsumoto, K., and Bargmann, C.I. (2001). The CaMKII UNC-43 activates the MAPKKK NSY-1 to execute a lateral signaling decision required for asymmetric olfactory neuron fates. Cell 105, 221-232.
11. Tanaka-Hino, M., Sagasti, A., Hisamoto, N., Kawasaki, M., Nakano, S., Ninomiya-Tsuji, J., Bargmann, C.I., and Matsumoto, K. (2002). SEK-1 MAPKK mediates Ca2+ signaling to determine neuronal asymmetric development in Caenorhabditis elegans. EMBO Rep. 3, 56-62.
12. Hengartner, M.O., Ellis, R.E., and Horvitz, H.R. (1992). Caenorhabditis elegans gene ced-9 protects cells from programmed cell death. Nature 356, 494-499.
13. Aderem, A., and Ulevitch, R.J. (2000). Toll-like receptors in the induction of the innate immune response. Nature 406, 782-787.
14. Pujol, N., Link, E.M., Liu, L.X., Kurz, C.L., Alloing, G., Tan, M.W., Ray, K.P., Solari, R., Johnson, C.D., and Ewbank, J.J. (2001). A reverse genetic analysis of components of the Toll signaling pathway in Caenorhabditis elegans. Curr. Biol. 11, 809-821.
15. Horng, T., and Medzhitov, R. (2001). Drosophila MyD88 is an adapter in the Toll signaling pathway. Proc. Natl. Acad. Sci. USA 98, 12654-12658.
16. Ernst, R.K., Guina, T., and Miller, S.I. (2001). Salmonella typhimurium outer membrane remodeling: role in resistance to host innate immunity. Microbes Infect. 3, 1327-1334.
17. Parkhill, J., Dougan, G., James, K.D., Thomson, N.R., Pickard, D., Wain, J., Churcher, C., Mungall, K.L., Bentley, S.D., Holden, M.T., et al. (2001). Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18. Nature 413, 848-852.
18. Brooke, J.S., and Valvano, M.A. (1996). Biosynthesis of inner core lipopolysaccharide in enteric bacteria identification and characterization of a conserved phosphoheptose isomerase. J. Biol. Chem. 271, 3608-3614.
19. MacLachlan, P.R., Kadam, S.K., and Sanderson, K.E. (1991). Cloning, characterization, and DNA sequence of the rfaLK region for lipopolysaccharide synthesis in Salmonella typhimurium LT2. J. Bacteriol. 173, 7151-7163.
20. Klena, J.D., Ashford, R.S., 2nd, and Schnaitman, C.A. (1992). Role of Escherichia coli K-12 rfa genes and the rfp gene of Shigella dysenteriae 1 in generation of lipopolysaccharide core heterogeneity and attachment of O antigen. J. Bacteriol. 174, 7297-7307.
21. Heinrichs, D.E., Yethon, J.A., and Whitfield, C. (1998). Molecular basis for structural diversity in the core regions of the lipopolysaccharides of Escherichia coli and Salmonella enterica. Mol. Microbiol. 30, 221-232.
22. Heinrichs, D.E., Yethon, J.A., Amor, P.A., and Whitfield, C. (1998). The assembly system for the outer core portion of R1- and R4-type lipopolysaccharides of Escherichia coli. The R1 core-specific beta-glucosyltransferase provides a novel attachment site for O-polysaccharides. J. Biol. Chem. 273, 29497-29505.
23. Medzhitov, R., and Janeway, C.A., Jr. (1997). Innate immunity: the virtues of a nonclonal system of recognition. Cell 91, 295-298.
24. Navarre, W.W., and Zychlinsky, A. (2000). Pathogen-induced apoptosis of macrophages: a common end for different pathogenic strategies. Cell Microbiol. 2, 265-273.
25. Choe, K.M., Werner, T., Stoven, S., Hultmark, D., and Anderson, K.V. (2002). Requirement for a peptidoglycan recognition protein (PGRP) in Relish activation and antibacterial immune responses in Drosophila. Science 296, 359-362.
26. Brenner, S. (1974). The genetics of Caenorhabditis elegans. Genetics 77, 71-94.
27. Wray, C., and Sojka, W.J. (1978). Experimental Salmonella typhimurium infection in calves. Res. Vet. Sci. 25, 139-143.
28. Ausubel, F.M., Brent, R., Kingston, R.E., Moore, D.D., Seidman, J.G., Smith, J.A., and Struhl, K. (1996). Current Protocols in Molecular Biology (New York: John Wiley and Sons).
29. Timmons, L., and Fire, A. (1998). Specific interference by ingested dsRNA. Nature 395, 854.
30. Fraser, A.G., Kamath, R.S., Zipperlen, P., Martinez-Campos, M., Sohrmann, M., and Ahringer, J. (2000). Functional genomic analysis of C. elegans chromosome I by systematic RNA interference. Nature 408, 325-330.
31. Gumienny, T.L., Lambie, E., Hartwieg, E., Horvitz, H.R., and Hengartner, M.O. (1999). Genetic control of programmed cell death in the Caenorhabditis elegans hermaphrodite germline. Development 126, 1011-1022.