Microsomal triglyceride transfer protein inhibitors: Discovery and synthesis of alkyl phosphonates as potent MTP inhibitors and cholesterol lowering agents

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 7, 2003, Pages 1337-1340

  Magnin, David R ^a   Biller, Scott A ^a   Wetterau, John ^a   Robl, Jeffrey A ^a   Dickson Jr , John K ^a   Taunk, Prakash ^a   Harrity, Thomas W ^a   Lawrence, R Michael ^a   Sun, C Q ^a   Wang, Tammy ^a   Logan, Janette ^a   Fryszman, Olga ^a   Connolly, Fergal ^a   Jolibois, Kern ^a   Kunselman, Lori ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; HYPOCHOLESTEROLEMIC AGENT; PHOSPHONIC ACID DERIVATIVE; PROTEIN INHIBITOR; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; HAMSTER; HUMAN; HUMAN CELL; MICROSOME; NONHUMAN; SYNTHESIS;

CRICETINAE;

EID: 0037424711     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(03)00116-1     Document Type: Article

References (11)

1. Rosamond W.D., Chambless L.E., Folsom A.R., Cooper L.S., Conwill D.E., Clegg L., Wang C.-H., Heiss G. N. Engl. J. Med. 339:1998;861.
2. Murray C.J.L., Lopez A.D. Lancet. 349:1997;1269.
3. Lablanche J.-M. Curr. Med. Res. Opin. 16:2001;285.
4. Chin-Dusting JayeP.F., Shaw JamesA. Expert Opin. Pharmacother. 2:2001;419.
5. Kane, J. P.; Havel, R. J. In Metabolic and Molecular Basis of Inherited Disease, Scriver, C. R.; Beaudet, A. L.; Sly, W. S.; Valle, D., Eds.; McGraw-Hill: New York, 1995; pp 1853-1885.
6. Wetterau J.R., Zilversmit D.B. Biochem. Biophys. Acta. 875:1986;610.
7. Wetterau J.R., Gordon D. A. Adv. Vasc. Biol. 5:1999;187.
8. Wetterau J.R., Gregg R.E., Harrit T.W., Arbeeny C., Cap M., Connolly F., Chu C.-H., George R.J., Gordon D.A., Jamil H., Jolibois K.G., Kunselman L.K., Lan S.-J., Maccagnan T.J., Ricci B., Yan M., Young D., Chen Y., Fryszman O.M., Logan J.V.H., Musial C.L., Poss M.A., Robl J.A., Simpkins L.M., Slusarchyk W.A., Sulsky R., Taunk P., Magnin D.R., Tino J.A., Lawrence R.M., Dickson J.K. Jr., Biller S.A. Science. 282:1998;751.
9. Jamil H., Gordon D.A., Eustice D.C., Brooks C.M., Dickson J.K. Jr., Chen Y., Ricci B., Chu C.-H., Harrity T.W. Proc. Natl. Acad. Sci. U.S.A. 93:1996;11991.
10. Koksh B., Sewald N., Hofmann H.J., Burger K., Jakubke H.D. Journal of Peptide Science. 3:1997;157.
11. Borensztajn R.M., Rone M., Kotlar T. Biochem. J. 156:1976;539.