Modification of ocular defects in mouse developmental glaucoma models by tyrosinase

Science

Volumn 299, Issue 5612, 2003, Pages 1578-1581

  Libby, Richard T ^a   Smith, Richard S ^a,b   Savinova, Olga V ^b   Zabaleta, Adriana ^b   Martin, Janice E ^a,b   Gonzalez, Frank J ^c   John, Simon W M ^a,b,d  

^a JACKSON LABORATORY   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOLOGY; GENES; MUTAGENESIS; POLYPEPTIDES;

CYTOCHROMES;

GENETIC ENGINEERING;

CYTOCHROME P450; CYTOCHROME P450 1B1; DOPA; MONOPHENOL MONOOXYGENASE;

GENE; MUTATION;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONGENITAL GLAUCOMA; CONTROLLED STUDY; DISEASE MODEL; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME MODIFICATION; EYE MALFORMATION; GENE MUTATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

ALBINISM, OCULAR; ANIMALS; ANTERIOR EYE SEGMENT; ARYL HYDROCARBON HYDROXYLASES; CORNEA; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GLAUCOMA; INTRAOCULAR PRESSURE; IRIS; LEVODOPA; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; MONOPHENOL MONOOXYGENASE; MUTATION; PHENOTYPE; PREGNANCY; TRABECULAR MESHWORK; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 0037423886     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1080095     Document Type: Article

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30. We thank F. Farley and J. Smith for assistance in preparing the manuscript and M. Anderson, D. Gould, T. Gridley, and T. O'Brien for critical reading of the manuscript, and L Bechtold for assistance with electron microscopy. Scientific support services at The Jackson Laboratory are subsidized by a core grant from the National Cancer Institute (grant CA34196). S.W.M.J. is an Associate Investigator of The Howard Hughes Medical Institute.