Downregulation of interleukin-12p35 and upregulation of interleukin-12p40 mRNA expression in heart allografts by blood transfusion from granulocyte colony-stimulating factor-treated donors

Cytokine

Volumn 21, Issue 1, 2003, Pages 27-31

  Ohmori, Ichiro ^a   Hayamizu, Keisuke ^a   Kitayama, Teruhiko ^a   Egi, Hiroyuki ^a   Aihaiti, Xuehelati ^a   Asahara, Toshimasa ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Granulocyte colony stimulating factor; Interleukin 12p35; Interleukin 12p40; Tacrolimus; Transplantation

Indexed keywords

INTERLEUKIN 12; MESSENGER RNA; PROTEIN P35; PROTEIN P40; PROTEIN SUBUNIT; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; TACROLIMUS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CELL; BLOOD TRANSFUSION; CONTROLLED STUDY; DOWN REGULATION; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; IMMUNOREGULATION; MALE; NONHUMAN; ORGAN DONOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RAT STRAIN; RECIPIENT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0037422697     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1043-4666(02)00492-1     Document Type: Article

References (17)

1. Egi H., Hayamizu K., Kitayama T., Ohmori I., Okajima M., Asahara T. Downregulation of both interleukin-12 and interleukin-2 in heart allografts by pretransplant host treatment with granulocyte colony-stimulating factor and tacrolimus. Cytokine. 18:2002;164-167.
2. +-ATPase modulate macrophage effector functions. Proc Natl Acad Sci USA. 96:1999;6324-6329.
3. Arpinati M., Green C.L., Heimfeld S., Heuser J.E., Anasetti C. Granulocyte-colony stimulating factor mobilizes T helper 2-inducing dendritic cells. Blood. 95:2000;2484-2490.
4. Sloand E.M., Kim S., Maciejewski J.P., Van Rhee F., Chaudhuri A., Barrett J., et al. Pharmacologic doses of granulocyte colony-stimulating factor affect cytokine production by lymphocytes in vitro and in vivo. Blood. 95:2000;2269-2274.
5. Hylkema M.N., van der Deen M., Pater J.M., Kampinga J., Nieuwenhuis P., Groen H. Single expression of CD45RC and RT6 in correlation with T-helper 1 and T-helper 2 cytokine patterns in the rat. Cell Immunol. 199:2000;89-96.
6. O'Garra A. Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity. 8:1998;275-283.
7. Gately M.K., Renzetti L.M., Magram J., Stern A.S., Adorini L., Gubler U., et al. The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses. Annu Rev Immunol. 16:1998;495-521.
8. Snijders A., Hilkens C.M., van der Pouw Kraan T.C., Engel M., Aarden L.A., Kapsenberg M.L. Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunit. J Immunol. 156:1996;1207-1212.
9. Boneberg E.M., Hareng L., Gantner F., Wendel A., Hartung T. Human monocytes express functional receptors for granulocyte colony-stimulating factor that mediate suppression of monokines and interferon-γ Blood. 95:2000;270-276.
10. Kato K., Shimozato O., Hoshi K., Wakimoto H., Hamada H., Yagita H., et al. Local production of the p40 subunit of interleukin 12 suppresses T-helper 1-mediated immune responses and prevents allogeneic myoblast rejection. Proc Natl Acad Sci USA. 93:1996;9085-9089.
11. Rothe H., O'Hara R.M. Jr, Martin S., Kolb H. Suppression of cyclophosphamide induced diabetes development and pancreatic Th1 reactivity in NOD mice treated with the interleukin (IL)-12 antagonist IL-12(p40)2. Diabetologia. 40:1997;641-646.
12. Snijders A., Kalinski P., Hilkens C.M.U., Kapsenberg M.L. High-level IL-12 production by human dendritic cells requires 2 signals. Int Immunol. 10:1998;1593-1598.
13. Kalinski P., Smits H.H., Schuitemaker J.H., Vieira P.L., van Eijk M., de Jong E.C., et al. IL-4 is a mediator of IL-12p70 induction by human Th2 cells: reversal of polarized Th2 phenotype by dendritic cells. J Immunol. 165:2000;1877-1881.
14. Kalinski P., Vieira P.L., Schuitemaker J.H.N., de Jong E.C., Kapsenberg M.L. Prostaglandin E2 is a selective inducer of interleukin-12 p40 (IL-12p40) production and an inhibitor of bioactive IL-12p70 heterodimer. Blood. 97:2001;3466-3469.
15. Gorgoni B., Maritano D., Marthyn P., Righi M., Poli V. C/EBPβ gene inactivation causes both impaired and enhanced gene expression and inverse regulation of IL-12p40 and p35 mRNAs in macrophages. J Immunol. 168:2002;4055-4062.
16. Hayamizu K., Zeng D., Huie P., Garcia-Ojeda M.E., Bloch D.A., Fong L., et al. Donor blood monocytes but not T or B cells facilitate long-term allograft survival after total lymphoid irradiation. Transplantation. 66:1998;585-593.
17. Hayamizu K., Lan F., Huie P., Sibley R.K., Strober S. Comparison of chimeric and non-chimeric tolerance using posttransplant TLI: cytokine expression and chronic rejection. Transplantation. 68:1999;1036-1044.