Synthetic study on the unique dimeric arylpiperazine: Access to the minor contaminant of aripiprazole

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 1, 2003, Pages 65-68

  Torisawa, Yasuhiro ^a   Shinhama, Koichi ^a   Nishi, Takao ^a   Minamikawa, Jun ichi ^a  

^a OTSUKA PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ARIPIPRAZOLE; PIPERAZINE DERIVATIVE; NEUROLEPTIC AGENT; QUINOLONE DERIVATIVE;

AMINATION; ARTICLE; ARYLATION; DIMERIZATION; DRUG CONTAMINATION; DRUG STRUCTURE; DRUG SYNTHESIS; ROOM TEMPERATURE; CHEMISTRY; SYNTHESIS;

AMINATION; ANTIPSYCHOTIC AGENTS; DIMERIZATION; DRUG CONTAMINATION; PIPERAZINES; QUINOLONES;

EID: 0037421082     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00857-0     Document Type: Article

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10. 2NHAr), which was fortunately eliminated during the transformation to Aripiprazole. Attempted N-alkylation of this triamine with excess 14 did not give any N-alkylated products under standard conditions. Details will be published elsewhere together with the contaminants of other arylpiperazines having different substituents.