Intravenous toxicity of fructose-1,6-bisphosphate in rats

Toxicology Letters

Volumn 143, Issue 1, 2003, Pages 73-81

  Nunes, Fernanda Bordignon ^a   Gaspareto, Patrick Barcelos ^a   Vianna Santos, Roberto Christ ^a   De Assis, Márcio ^a   Graziottin, Cássio Meyer ^a   Biolchi, Vanderlei ^a   Alves Filho, José Carlos Farias ^a   Lunardelli, Adroaldo ^a   ávila, Luís D ^a   Simões Pires, Melissa Guerra ^a   Wächter, Paulo Harald ^a   De Oliveira, Jarbas Rodrigues ^a  

^a PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Fructose 1,6 bispbosphate; LD50; PROBIT; Toxicity

Indexed keywords

CALCIUM ION; FRUCTOSE 1,6 BISPHOSPHATE; PHOSPHATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ELECTROCARDIOGRAM; HEART ARREST; LETHAL DOSE; MALE; NONHUMAN; PHOSPHATE BLOOD LEVEL; PRIORITY JOURNAL; RAT; STATISTICAL SIGNIFICANCE; TOXICITY;

ANIMALS; CALCIUM; ELECTROCARDIOGRAPHY; FRUCTOSEDIPHOSPHATES; INJECTIONS, INTRAVENOUS; LETHAL DOSE 50; MALE; PHOSPHATES; RATS; RATS, WISTAR;

ANIMALIA; RATTUS NORVEGICUS;

EID: 0037420887     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(03)00075-4     Document Type: Article

References (28)

1. Bellet S., Jedlicka J. Sinoventricular conduction. Am. J. Cardiol. 24:1969;831.
2. Cattani L., Costrini R., Cerilli C. Fructose-1,6-diphosphate dependence on the toxicity and uptake of potassium ions. Agressologie. 21:1980;263.
3. Cattani L., Costrini R., Lazzarino G., Diana M., Galzigna L. Fructose-1,6-diphosphate counteracts potassium effects on cardiac muscle. Pharmacol. Res. Commun. 16:1984;785-793.
4. Chu S.J., Chang D.M., Wang D., Chen Y.H., Hsu C.W., Hsu K. Fructose-1,6-diphosphate attenuates acute lung injury induced by ischemia-reperfusion in rats. Crit. Care Med. 30:(7):2002;1605-1609.
5. De Oliveira J.R., Rosa J.L., Ambrosio S., et al. Effect of galactosamine on hepatic carbohydrate metabolism; protective role of fructose-1,6-bisphosphate. Hepatology. 15:(6):1992;1147-1153.
6. Didlake R., Kirchner K.A., Lewin J., Bower I.D., Markov A.K. Protection from ischemic renal injury by fructose-1,6-diphosphate infusion in the rat. Circ. Shock. 16:(2):1985;205-212.
7. Eddy L.J., Chambers D., Honig S., et al. Lack of a direct metabolic effect of fructose-1,6-diphosphate in ischemia myocardium. Am. J. Physiol. 24:1981;H576-H582.
8. Farias I.A., Smith E.E., Markov A.K. Prevention of ischemic-hypoxic brain injury and death in rabbits with fructose-1,6-diphosphate. Stroke. 21:(4):1990;606-613.
9. Fisher, R.A., 1971. Tabelas Estatísticas para Pesquisa em Biologia, Medicina e Agricultura. São Paulo e Editora Poligono.
10. Galzigna L., Rigobello M. Proton and potassium fluxes in rat red blood cells incubated with sugar phosphates. Experientia. 42:1986;138-139.
11. Giacosa, A., Sukkar, G.S., Chiti, D., Marcheti, M., 1987. Effects of fructose-1,6-diphosphate on the hyperglycemic response to intravenous glucose load. Current Therapeutic Research 41, 874-881.
12. Gregory G.A., Yu A.C.H., Chan P.H. Fructose-l,6-bisphosphate protects astrocytes from hypoxic damage. J. Cereb. Blood Flow Metab. 9:1989;29-34.
13. Hardin C.D., Roberts T.M. Metabolism of exogenously applied fructose-1,6-bisphosphate in hypoxic vascular smooth muscle. Am. J. Physiol. 267:1994;H2325-H2332.
14. Hassinen I.E., Nuutinen E.M., Ito K., Nioka S., Lazzarino G., Giardina B., Chance B. Mechanism of the effect of exogenous fructose-1,6-bisphosphate on myocardial energy metabolism. Circulation. 83:1981;584-593.
15. Kirttley M.E., McKay M. Fructose-1,6-disphosphate, a regulator of metabolism. Mol. Cell Biochem. 18:1977;141.
16. Lazzarino G., Cattani L., Costrini R., Mulieri L., Candiani A., Galzinga L. Increase of intraerythrocytic fructose-1,6-diphosphate after incubation of whole human blood with fructose-1,6-diphosphate. Clin. Biochem. 17:1984;42-45.
17. Lazzarino G., Nuutinen M.E., Tavazzi B., Cerroni L., DiPierro D., Giardina B. Preserving effect of fructose-1,6-bisphosphate on high-energy phosphate compounds during anoxia and reperfusion in isolated Langendorff-perfused rate hearts. J. Mol. Cell Cardiol. 23:1991;13.
18. Markov A.K., Brumley M.A., Figueroa A., Skeleton T.H., Lehan P.H. Hemodynamic effects of fructose-1,6-diphosphate in patients with normal and impaired left ventricular function. Am. Heart J. 133:(5):1997;541-549.
19. Markov A.K., Neely W.A., Didlake R.H., Terry H., Causey A., Lehan P.H. Metabolic response to fructose-1,6-diphosphate in healthy subjects. Metabolism. 49:(6):2000;698-703.
20. Nakai T., Tanimura H., Tabuse K., Nagai Y., Mori K., Yamoto K. Beneficial effects of fructose-1,6-diphosphate infusion on liver regeneration after ischemic liver injury. Gastroenterol. Jpn. 26:(5):1991;611-618.
21. Nunes F.B., Pires M.G.S., Alves Filho J.C.A., Wachter P.H., De Oliveira J.R. Physiopathological studies in septic rats and the use of fructose-1,6-bisphosphate as cellular protection. Crit. Care Med. 30:(9):2002;2069-2074.
22. + permeability in isolated rat hepatocytes. Am. J. Physiol. 273:1997;C473-C478.
23. Shargel L., Yu A.B.C. Applied Biopharmaceutics and Pharmacokinetics. fourth ed:1999;McGraw-Hill, New York.
24. Squadrito F., Stunuolo R., Atlavilla D., Campo G.M., Trimarchi G.R., Scuri R., Caputi A.P. Effects of fructose-1,6-diphosphate on splanehnic artery occlusion shock in the rat. Resuscitation. 18:(2-3):1989;299-307.
25. Sun J., Farias L.A., Markov A.K. Fructose-1,6-diphosphate prevents intestinal ischemic reperfusion injury and death in rats. Gastroenterology. 98:(1):1990;117-126.
26. Surawicz B., MacDonald M.G., Kaljot V., Bettinger J.C. Treatment of cardiac arrhytmias with salts of ethylenediamine-tetra-acetic acid (EDTA). Am. Heart J. 58:1959;493.
27. Tallarida R.J., Murray R.B. Manual of Pharmacologic Calculations with Computer Programs. second ed:1987;Springer, New York.
28. Vexler Z., Margarita B., Ursell P.C., Sola A., Ferriero D.M., Gregory G.A. Toxity of fructose-1,6-biphosphate in developing normoxic rats. J. Pharmacol. Toxicol. 84:1999;115-121.