Effects of pretreatment with verapamil on the toxicokinetics of soman in rabbits and distribution in mouse brain and diaphragm

Toxicology Letters

Volumn 138, Issue 3, 2003, Pages 227-233

  Li, Jin Tong ^a   Ruan, Jin Xiu ^a   Zhang, Zhen Qing ^a   Yu, Wei Dong ^a   Song, Zheng Yan ^a   Qiao, Jian Zhong ^a  

^a BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

Author keywords

Detoxification; Distribution; Elimination; Soman; Toxicokinetics; Verapamil

Indexed keywords

SOMAN; VERAPAMIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BRAIN; CHEMICAL ANALYSIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DETOXIFICATION; DIAPHRAGM; DOSE TIME EFFECT RELATION; DRUG EFFECT; MOUSE; NONHUMAN; PLASMA CLEARANCE; PRIORITY JOURNAL; RABBIT; TISSUE DISTRIBUTION; TOXICOKINETICS;

ANIMALS; AREA UNDER CURVE; BRAIN; CALCIUM CHANNEL BLOCKERS; CHOLINESTERASE INHIBITORS; CHROMATOGRAPHY, GAS; DIAPHRAGM; HALF-LIFE; METABOLIC DETOXICATION, DRUG; MICE; RABBITS; SOMAN; STEREOISOMERISM; VASODILATOR AGENTS; VERAPAMIL;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0037416715     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(02)00415-0     Document Type: Article

References (15)

1. Benschop H.P., Koningas C.A.G., Van Genderen J., De Jong L.P.A. Isolation, anticholinesterase properties, and acute toxicity in mice of the four stereoisomers of the nerve agent soman. Toxicol. Appl. Pharmacol. 72:1984;61-74.
2. De Jong L.P.A., Van Duk C., Berhitoe D., Benschop H.P. Hydrolysis and bingding of a toxic stereoisomers of soman in plasma and tissue homogenates from rat, guinea pig and marmoset, and in human plasma. Biochem. Pharmacol. 46:1993;1413-1419.
3. Dobric, S., Milovanovic, S.R., 2000. The protective efficacy of calcium channel blockers in soman-poisoned rats. In The third chemical and biological medical treatment symposium. Spiez Switzerland.
4. Due A.H., Trap H.C., Langenberg J.P., Benschop H.P. Toxicokinetics of soman stereoisomers after subcutaneous administration to atropinized guinea pigs. Arch. Toxicol. 68:1994;60-63.
5. Karlsson B.M., Fredriksson S.A., Sellstrom A., Algers G. The protective effect of nimodipine, a calcium antagonist, and its influence on soman clearance in the anaesthetized rabbit. J. Pharm. Pharmacol. 46:1994;123-127.
6. Karlsson B.M., Waara L.M., Fredriksson S.A., Koskinen L.D. The effect of the calcium antagonist nimodipine on detoxification of soman in anaesthetized rabbits. J. Pharm. Pharmacol. 49:1997;296-300.
7. Kentera D., Susic D., Stamenovic B. The effect of HS-3 and HS-6 on cardiovascular changes in caused by soman. Arh. Hig. Rada Toksikol. 33:1982;143-150.
8. Langenberg J.P., Dijk C.V., Sweeney R.E., Mexwell D.M., De Jong L.P.A., Benschop H.P. Development of a physiologically based model for the toxicokinetics of C(±)P(±)-soman in the atropinized guinea pig. Arch. Toxicol. 71:1997;320-331.
9. Langenberg J.P., Spruit H.E., van der Wiel H.J., Trap H.C., Helmich R.B., Bergers W.W.A., Van Helden H.P.M., Benschop H.P. Inhalation toxicokinetics of soman stereoisomers in the atropinized guinea pig with nose-only exposure to soman vapor. Toxicol. Appl. Pharmacol. 151:1998;79-87.
10. Li J.T., Ruan J.X., Zhang Z.-Q., Yuan S.L., Song Z.Y., Han D. Influence of portal vein and liver artery ligation on the toxicokinetics of soman in rabbits. Toxicol. Lett. 135:(1):2002;73-78.
11. 3H]Soman in mice. Acta Phamacol Sin. 23, 937-941.
12. Maxwell D.M., Lenz D.E., Groff W.A., Kaminskii A., Froehlich H. The effects of blood flow and detoxification in vivo cholinesterase inhibition by soman in rats. Toxicol. Appl. Pharmacol. 88:1987;66-76.
13. Maxwell D.M. The Specificity of carboxylesterase protection against the toxicity of organo-phosphorus compounds. Toxicol. Appl. Pharmacol. 114:1992;306-312.
14. 3H]soman and its pharmacological effects in mice. Toxicol. Appl. Pharmacol. 80:1985;409-420.
15. Singh A.K., Zeleznikar R.J. Jr., Drewes L.R. Analysis of soman and sarin in blood utilizing a sensitive gas chromatography-mass spectrometry method. J. Chromatogr. 24:1985;163-172.