The biocatalytic conversion of 8-hydroxymanzamine A to manzamine A

Tetrahedron Letters

Volumn 44, Issue 6, 2003, Pages 1291-1293

  Kasanah, Noer ^a   Rao, Karumanchi V ^a   Yousaf, Muhammad ^a   Wedge, David E ^b   Hamann, Mark T ^a  

^a UNIVERSITY OF MISSISSIPPI   (United States)

^b AGRICULTURAL RESEARCH SERVICE   (United States)

Author keywords

8 hydroxymanzamine A; Fusarium solani; Selective dehydroxylation; Streptomyces seokies

Indexed keywords

8 HYDROXYMANZAMINE A; ALKALOID; ANTIMALARIAL AGENT; MANZAMINE A; UNCLASSIFIED DRUG;

ARTICLE; ASSAY; BIOCATALYST; BIOTRANSFORMATION; CATALYSIS; DRUG ACTIVITY; DRUG SYNTHESIS; FERMENTATION; FUSARIUM SOLANI; HYDROXYLATION; MALARIA; NONHUMAN; STREPTOMYCES;

FUSARIUM; FUSARIUM SOLANI; MURINAE; STREPTOMYCES;

EID: 0037415513     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(02)02816-2     Document Type: Article

References (10)

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3. El Sayed K.A., Hamann M.T., Waddling C.A., Jansen C., Lee S.K., Dunstan C.A., Pezzuto J.M. J. Org. Chem. 63:1998;7449-7455.
4. El Sayed K.A., Mayer A.M.S., Kelly M., Hamann M.T. J. Org. Chem. 64:1999;9258-9260.
5. Fusarium species: F. oxysporium fsp. apii race 2, F. proliferatum, F. oxysporium, F. solani, F. subglutinans, F. oxysporium fsp. asparagi, F. oxysporium fsp. basilicum. These cultures were obtained from USDA-ARS.
6. Yousaf M., El Sayed K.A., Rao K.V., Lim C.W., Hu J.-F., Kelly M., Franzblau S.G., Zhang F., Peraud O., Hill R.T., Hamann M.T. Tetrahedron. 58:2002;7397-7402.
7. HPLC: column 250×10 mm, 5 μ Luna C8 Phenomenex, mobile phase: water and acetonitrile with 0.1% TFA. Isocratic elution for first 10 min with 80% water followed by gradient elution at constant flow rate 2 mL/min.
8. Streptomyces seokies SC 1627 was obtained from Department of Pharmacognosy, School of Pharmacy, The University of Mississippi.
9. El Sayed K.A., Kelly M., Kara U.A.K., Ang K.K.H., Katsuyama M., Dunbar D.C., Khan A.A., Hamann M.T. J. Am. Chem. Soc. 123:2001;1804-1808.
10. Ang K.K.H., Holmes M.J., Higa T., Hamann M.T., Kara U.A.K. Antimicrob. Agents Chemother. 44:2000;1645-1649.