Human fetal and tumor alpha-fetoproteins differ in conformationally dependent epitope variants expression

Immunology Letters

Volumn 85, Issue 3, 2003, Pages 261-270

  Yazova, Alla K ^a   Goussev, Anatoly I ^a   Christiansen, Michael ^b   Kushlinsky, Nikolay E ^a   Stogova, Elena ^a   Norgaard Pedersen, Bent ^b   Abelev, Garry I ^a  

^a N N BLOKHIN RUSSIAN CANCER RESEARCH CENTER   (Russian Federation)

^b Statens Seruminstitut ^*  (Denmark)

Author keywords

Alpha fetoprotein; Alpha fetoprotein epitopes; Conformationally dependent epitopes; Epitope variants of alpha fetoprotein; Immunoaffinity electrochromatography; Monoclonal antibodies to human alpha fetoprotein

Indexed keywords

ALPHA FETOPROTEIN; CONFORMATIONALLY DEPENDENT EPITOPE 106; CONFORMATIONALLY DEPENDENT EPITOPE D; EPITOPE; MONOCLONAL ANTIBODY; PYROXYLIN; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

AMNION FLUID; ANTIBODY AFFINITY; ANTIGEN EXPRESSION; ANTIGENIC VARIATION; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FETUS; FETUS DEVELOPMENT; GERM CELL TUMOR; HUMAN; HUMAN CELL; IMMUNOAFFINITY CHROMATOGRAPHY; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MOLECULE; PRIORITY JOURNAL; PROTEIN ANALYSIS; QUANTITATIVE ANALYSIS; SAMPLE; SERODIAGNOSIS; SERUM; UMBILICAL CORD BLOOD;

ALPHA-FETOPROTEINS; AMNIOTIC FLUID; ANTIBODIES, MONOCLONAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; EPITOPES; FETUS; HUMANS; NEOPLASMS; PROTEIN CONFORMATION;

EID: 0037415402     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-2478(02)00207-9     Document Type: Article

References (19)

1. Abelev G.I. Alpha-fetoprotein: 25 years of study. Tumor Biol. 10:1989;63-74.
2. Norgaard-Pedersen B., Christiansen M., Jensen S.P. Alpha-fetoprotein in fetal pathophysiology. Pasqualini J.R., Scholler R. Hormones and Fetal Pathophysiology. 1991.
3. Deutsch H.F. Chemistry and biology of alpha-fetoprotein. Adv. Cancer Res. 56:1991;253-321.
4. Breborowich J. Microheterogeneity of human alpha-fetoprotein. Tumor Biol. 9:1988;3-14.
5. Taketa K. α-Fetoprotein. Reeval. Hepatol. 12:1990;1420-1432.
6. Mizejewski G.J. Alpha-fetoprotein structure and function: relevance to isoforms, epitopes, and conformational variants. Exp. Biol. Med. 226:2001;377-408.
7. Kitagawa H., Ohkouchi E., Hata J., Tsuchida Y., Fukada A., Tada T. Monoclonal antibodies with fine specificities distinguishing alpha-fetoproteins of hepatoma and yolk sac tumor origin. Jpn. Cancer Res. (Gann). 77:1986;1012-1017.
8. Sittenfeld A., Moreno E. A sensitive blotting system for detection of α-fetoprotein variants with monoclonal and polyclonal antibodies. Immunol. Meth. 106:1988;19-26.
9. Christiansen M., Yazova A.K., Karamova E.R., Andre'ev A.V., Goussev A.I., Mortensen V., Pettersson K., Kogh C., Norgaard-Pedersen B., Abelev G.I. Epitopes of human alpha-fetoprotein: construction of an epitope map from a large number of monoclonal antibodies. J. Tumor Marker Oncol. 9:1994;57-68.
10. Yakimenko E.F., Karamova E.R., Goussev A.I., Hilgers J., Abelev G.I., Yazova A.K. Epitope mapping of human alpha-fetoprotein. Tumor Biol. 19:1998;301-309.
11. Nusted K., Paus E., Kierulf B., Bormer O.P. Specificity and affinity of 30 monoclonal antibodies against alpha-fetoprotein. Tumor Biol. 19:1998;293-300.
12. Kang Y., Matsuura E., Sakamoto T., Sakai M., Nishi S. Analysis of epitopes of mouse monoclonal antibodies against human alpha-fetoprotein. Tumor Biol. 22:2001;254-261.
13. Yakimenko E.F., Yazova A.K., Goussev A.I., Abelev G.I. Epitope mapping of human alpha-fetoprotein. Biochemistry (Moscow). 66:(5):2001;650-657.
14. Karamova E.R., Yazova A.K., Goussev A.I., Yakimenko E.F., Abelev G.I. Conformational variants of human alpha-fetoprotein. Tumor Biol. 19:1998;310-317.
15. E.F. Yakimenko, A.K. Yazova, A.I. Gussev, M. Christiansen, E.R. Karamova, G.I. Abelev, Epitopes of human alpha-fetoprotein (hAFP), Tumor Biol. 19 (Suppl. 2) (1998) 23 [Abstr. XXVI. ISOBM].
16. A.K. Yazova, E.F. Yakimenko, E.R. Karamova, A.I. Goussev, G.I. Abelev, Epitope structure of human alpha-fetoprotein (AFP) and its variants in AFP of different origin, Tumor Biol. 18 (Suppl. 2) (1997) 106 [Abstr. XXV. ISOBM].
17. Yazova A.K., Goussev A.I., Poltoranina V.S., Yakimenko E.F. Human α-fetoprotein epitopes as revealed by monoclonal antibodies. Immunol. Lett. 25:1990;325-330.
18. Abelev G., Karamova E. Counterflow immunoisotachophoresis and immunoaffinity electrochromatography on porous membranes. Lefkovitss I. Immunology Methods Manual. 4:1997;499-513 Academic Press, London.
19. Taketa K., Kamakura K., Satomura S., Taga H. Lectin-dependent modulation of interaction between human alpha-fetoprotein and its monoclonal antibodies. Tumor Biol. 19:1998;318-328.