Topically administered CB2-receptor agonist, JWH-133, does not decrease intraocular pressure (IOP) in normotensive rabbits

Life Sciences

Volumn 72, Issue 7, 2003, Pages 837-842

  Laine, Krista ^a   Järvinen, Kristiina ^a   Järvinen, Tomi ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

CB2 receptor; CP55,940; Intraocular pressure; JWH 133; Rabbit

Indexed keywords

1 DEOXY 3 (1,1 DIMETHYLBUTYL) DELTA8 TETRAHYDROCANNABINOL; 2 HYDROXYPROPYL BETA CYCLODEXTRIN; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR AGONIST; DRUG VEHICLE; EYE DROPS; PROPYLENE GLYCOL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG FORMULATION; EYE; FEMALE; INTRAOCULAR PRESSURE; MALE; NONHUMAN; PRESSURE MEASUREMENT; RABBIT;

ADMINISTRATION, TOPICAL; ANIMALS; ANTINEOPLASTIC AGENTS; CANNABINOIDS; CYCLOHEXANOLS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; INTRAOCULAR PRESSURE; MALE; RABBITS; RECEPTORS, CANNABINOID; RECEPTORS, DRUG;

ORYCTOLAGUS CUNICULUS;

EID: 0037414741     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(02)02339-1     Document Type: Article

References (18)

1. Hepler R.S., Frank I.M. Marihuana smoking and intraocular pressure. Journal of American Medical Association. 217:1971;1392.
2. Mikawa Y., Matsuda S., Kanagawa T., Tajika T., Ueda N., Mimura Y. Ocular activity of topically administered anandamide in the rabbit. Japanese Journal of Ophthalmology. 41:1997;217-220.
3. Pate D.W., Järvinen K., Urtti A., Jarho P., Järvinen T. Ophthalmic arachidonylethanolamide decreases intraocular pressure in normotensive rabbits. Current Eye Research. 14:1995;791-797.
4. Pate D.W., Järvinen K., Urtti A., Jarho P., Mahadevan V., Järvinen T. Effects of topical alpha-substituted anandamides on intraocular pressure in normotensive rabbits. Pharmaceutical Research. 14:1997;1738-1743.
5. Song Z.H., Slowey C.A. Involvement of cannabinoid receptors in the intraocular pressure-lowering effects of WIN55313-2. Journal of Pharmacology and Experimental Therapeutics. 292:2000;136-139.
6. Porcella A., Maxia C., Gessa G.L., Pani L. The synthetic cannabinoid WIN55212-2 decreases the intraocular pressure in human glaucoma resistant to conventional therapies. European Journal of Neurosciences. 13:2001;409-412.
7. Devane W.A., Dysarz F.A. 3rd, Johnson M.R., Melvin L.S., Howlett A.C. Determination and characterization of a cannabinoid receptor in rat brain. Molecular Pharmacology. 34:1988;605-613.
8. Munro S., Thomas K.L., Abu-Shaar M. Molecular characterization of a peripheral receptor for cannabinoids. Nature. 365:1993;61-65.
9. Straiker A.J., Maguire G., Mackie K., Lindsey J. Localization of cannabinoid CB1 receptors in the human anterior eye and retina. Investigative Ophthalmology & Visual Sciences. 40:1999;2442-2448.
10. 1 receptor expression, activation and detection of endogenous ligand in trabecular meshwork and ciliary process tissues. European Journal of Pharmacology. 431:2001;277-286.
11. Lu Q., Straiker A., Lu Q., Maquire G. Expression of CB2 cannabinoid receptor mRNA in adult rat retina. Visual Neuroscience. 17:2000;91-95.
12. Malan T.P. Jr., Ibrahim M.M., Deng H., Liu Q., Mata H.P., Vanderah T., Porreca F., Makriyannis A. CB2 cannabinoid receptor-mediated peripheral antinociception. Pain. 93:2001;239-245.
13. 2 receptor. Bioorganic & Medicinal Chemistry. 7:1999;2905-2914.
14. Jarho P., Järvinen K., Urtti A., Stella V., Järvinen T. Modified β-cyclodextrin (SBE7-β-CyD) with viscous vehicle improves the ocular delivery and tolerability of pilocarpine prodrugs in rabbit. Journal of Pharmacy and Pharmacology. 48:1996;263-269.
15. Felder C.C., Joyce K.E., Briley E.M., Mansouri J., Mackie K., Blond O., Lai Y., Ma A.L., Mitchell R.L. Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors. Molecular Pharmacology. 48:1995;443-450.
16. Pate D.W., Järvinen K., Urtti A., Mahadevan V., Järvinen T. Effect of the CB1 receptor antagonist, SR141716A, on cannabinoid-induced ocular hypotension in normotensive rabbits. Life Sciences. 63:1998;2181-2188.
17. Laine K., Järvinen K., Pate D.W., Urtti A., Järvinen T. Effect of the enzyme inhibitor, phenylmethylsulfonyl fluoride, on the IOP profiles of topical anandamides. Investigative Ophthalmology & Visual Sciences. 43:2002;393-397.
18. Porcella A., Maxia C., Gessa G.L., Pani L. The human eye expresses high levels of CB1 cannabinoid receptor mRNA and protein. European Journal of Neuroscience. 12:2000;1123-1127.