An improved preparation of 3,5-bis(trifluoromethyl)acetophenone and safety considerations in the preparation of 3,5-bis(trifluoromethyl)phenyl Grignard reagent

Journal of Organic Chemistry

Volumn 68, Issue 9, 2003, Pages 3695-3698

  Leazer Jr , Johnnie L ^a   Cvetovich, Raymond ^a   Tsay, Fuh Rong ^a   Dolling, Ulf ^a   Vickery, Thomas ^a   Bachert, Donald ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACCIDENT PREVENTION; DIFFERENTIAL THERMAL ANALYSIS; SOLVENTS; SYNTHESIS (CHEMICAL);

REACTION SYSTEM SCREENING TOOL (RSST);

ORGANIC COMPOUNDS;

3,5 BIS(TRIFLUOROMETHYL)ACETOPHENONE; 3,5 BIS(TRIFLUOROMETHYL)PHENYL GRIGNARD REAGENT; ACETOPHENONE DERIVATIVE; REAGENT; UNCLASSIFIED DRUG;

ARTICLE; BROMINATION; DRUG STRUCTURE; DRUG SYNTHESIS; SAFETY; STRUCTURE ANALYSIS; THERMAL ANALYSIS;

EID: 0037414554     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo026903n     Document Type: Article

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