Functional analysis of CFTR chloride channel activity in cells with elevated MDR1 expression

Biochemical and Biophysical Research Communications

Volumn 304, Issue 2, 2003, Pages 248-252

  Cao, Lishuang ^a   Owsianik, Grzegorz ^a   Jaspers, Martine ^a   Janssens, Annelies ^a   Cuppens, Harry ^a   Cassiman, Jean Jacques ^a   Nilius, Bernd ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

cAMP activated chloride channel; CFTR; Co expression; Cystic fibrosis; Doxorubicin; MDR1; Multidrug resistance; Patch clamp technique

Indexed keywords

CHLORIDE CHANNEL; CYCLIC AMP; DOXORUBICIN; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; PROTEIN; TRANSMEMBRANE CONDUCTANCE REGULATOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STRAIN CACO 2; CELL STRAIN COS1; CHLORIDE CURRENT; CONCENTRATION RESPONSE; CONTROLLED STUDY; HUMAN; HUMAN CELL; INCUBATION TIME; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; UPREGULATION;

CUCUMBER MOSAIC VIRUS;

EID: 0037414432     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(03)00581-3     Document Type: Article

References (33)

1. Riordan J.R., Rommens J.M., Kerem B., Alon N., Rozmahel R., Grzelczak Z., Zielenski J., Lok S., Plavsic N., Chou J.L.et al. Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. Science. 245:1989;1066-1073.
2. Anderson M.P., Gregory R.J., Thompson S., Souza D.W., Paul S., Mulligan R.C., Smith A.E., Welsh M.J. Demonstration that CFTR is a chloride channel by alteration of its anion selectivity. Science. 253:1991;202-205.
3. Bear C.E., Li C.H., Kartner N., Bridges R.J., Jensen T.J., Ramjeesingh M., Riordan J.R. Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR). Cell. 68:1992;809-818.
4. Schwiebert E.M., Benos D.J., Egan M.E., Stutts M.J., Guggino W.B. CFTR is a conductance regulator as well as a chloride channel. Physiol. Rev. 79:1999;S145-S166.
5. Anderson M.P., Berger H.A., Rich D.P., Gregory R.J., Smith A.E., Welsh M.J. Nucleoside triphosphates are required to open the CFTR chloride channel. Cell. 67:1991;775-784.
6. Cheng S.H., Rich D.P., Marshall J., Gregory R.J., Welsh M.J., Smith A.E. Phosphorylation of the R domain by cAMP-dependent protein kinase regulates the CFTR chloride channel. Cell. 66:1991;1027-1036.
7. Nagel G., Hwang T.C., Nastiuk K.L., Nairn A.C., Gadsby D.C. The protein kinase A-regulated cardiac Cl-channel resembles the cystic fibrosis transmembrane conductance regulator. Nature. 360:1992;81-84.
8. Quinton P.M., Reddy M.M. Control of CFTR chloride conductance by ATP levels through non-hydrolytic binding. Nature. 360:1992;79-81.
9. Chang X.B., Tabcharani J.A., Hou Y.X., Jensen T.J., Kartner N., Alon N., Hanrahan J.W., Riordan J.R. Protein kinase A (PKA) still activates CFTR chloride channel after mutagenesis of all 10 PKA consensus phosphorylation sites. J. Biol. Chem. 268:1993;11304-11311.
10. Rich D.P., Berger H.A., Cheng S.H., Travis S.M., Saxena M., Smith A.E., Welsh M.J. Regulation of the cystic fibrosis transmembrane conductance regulator Cl-channel by negative charge in the R domain. J. Biol. Chem. 268:1993;20259-20267.
11. Tsui L.C. The spectrum of cystic fibrosis mutations. Trends Genet. 8:1992;392-398.
12. Cutting G.R. Spectrum of mutations in cystic fibrosis. J. Bioenerg. Biomembr. 25:1993;7-10.
13. Juliano R.L., Ling V. A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochim. Biophys. Acta. 455:1976;152-162.
14. Ueda K., Cornwell M.M., Gottesman M.M., Pastan I., Roninson I.B., Ling V., Riordan J.R. The mdr1 gene, responsible for multidrug-resistance, codes for P-glycoprotein. Biochem. Biophys. Res. Commun. 141:1986;956-962.
15. Cordon-Cardo C., O'Brien J.P., Boccia J., Casals D., Bertino J.R., Melamed M.R. Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues. J. Histochem. Cytochem. 38:1990;1277-1287.
16. Thiebaut F., Tsuruo T., Hamada H., Gottesman M.M., Pastan I., Willingham M.C. Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues. Proc. Natl. Acad. Sci. USA. 84:1987;7735-7738.
17. Arceci R.J., Croop J.M., Horwitz S.B., Housman D. The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus. Proc. Natl. Acad. Sci. USA. 85:1988;4350-4354.
18. Arceci R.J., Baas F., Raponi R., Horwitz S.B., Housman D., Croop J.M. Multidrug resistance gene expression is controlled by steroid hormones in the secretory epithelium of the uterus. Mol. Reprod. Dev. 25:1990;101-109.
19. Bremer S., Hoof T., Wilke M., Busche R., Scholte B., Riordan J.R., Maass G., Tummler B. Quantitative expression patterns of multidrug-resistance P-glycoprotein (MDR1) and differentially spliced cystic-fibrosis transmembrane-conductance regulator mRNA transcripts in human epithelia. Eur. J. Biochem. 206:1992;137-149.
20. Engelhardt J.F., Yankaskas J.R., Ernst S.A., Yang Y., Marino C.R., Boucher R.C., Cohn J.A., Wilson J.M. Submucosal glands are the predominant site of CFTR expression in the human bronchus. Nat. Genet. 2:1992;240-248.
21. Kartner N., Augustinas O., Jensen T.J., Naismith A.L., Riordan J.R. Mislocalization of delta F508 CFTR in cystic fibrosis sweat gland. Nat. Genet. 1:1992;321-327.
22. Puchelle E., Gaillard D., Ploton D., Hinnrasky J., Fuchey C., Boutterin M.C., Jacquot J., Dreyer D., Pavirani A., Dalemans W. Differential localization of the cystic fibrosis transmembrane conductance regulator in normal and cystic fibrosis airway epithelium. Am. J. Respir. Cell Mol. Biol. 7:1992;485-491.
23. Sood R., Bear C., Auerbach W., Reyes E., Jensen T., Kartner N., Riordan J.R., Buchwald M. Regulation of CFTR expression and function during differentiation of intestinal epithelial cells. EMBO J. 11:1992;2487-2494.
24. Trezise A.E., Romano P.R., Gill D.R., Hyde S.C., Sepulveda F.V., Buchwald M., Higgins C.F. The multidrug resistance and cystic fibrosis genes have complementary patterns of epithelial expression. EMBO J. 11:1992;4291-4303.
25. Trezise A.E., Linder C.C., Grieger D., Thompson E.W., Meunier H., Griswold M.D., Buchwald M. CFTR expression is regulated during both the cycle of the seminiferous epithelium and the oestrous cycle of rodents. Nat. Genet. 3:1993;157-164.
26. Breuer W., Slotki I.N., Ausiello D.A., Cabantchik I.Z. Induction of multidrug resistance downregulates the expression of CFTR in colon epithelial cells. Am. J. Physiol. 265:1993;C1711-C1715.
27. Baudouin-Legros M., Brouillard F., Tondelier D., Hinzpeter A., Edelman A. Effect of ouabain on CFTR gene expression in human Calu-3 cells. Am. J. Physiol. Cell Physiol. 284:2003;C620-C626.
28. Trezise A.E., Ratcliff R., Hawkins T.E., Evans M.J., Freeman T.C., Romano P.R., Higgins C.F., Colledge W.H. Co-ordinate regulation of the cystic fibrosis and multidrug resistance genes in cystic fibrosis knockout mice. Hum. Mol. Genet. 6:1997;527-537.
29. Vankeerberghen A., Lin W., Jaspers M., Cuppens H., Nilius B., Cassiman J.J. Functional characterization of the CFTR R domain using CFTR/MDR1 hybrid and deletion constructs. Biochemistry. 38:1999;14988-14998.
30. Wei L., Vankeerberghen A., Cuppens H., Eggermont J., Cassiman J.J., Droogmans G., Nilius B. Interaction between calcium-activated chloride channels and the cystic fibrosis transmembrane conductance regulator. Pflugers Arch. 438:1999;635-641.
31. Hamill O.P., Marty A., Neher E., Sakmann B., Sigworth F.J. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch. 391:1981;85-100.
32. Shen D.W., Fojo A., Chin J.E., Roninson I.B., Richert N., Pastan I., Gottesman M.M. Human multidrug-resistant cell lines: increased mdr1 expression can precede gene amplification. Science. 232:1986;643-645.
33. Ueda K., Cardarelli C., Gottesman M.M., Pastan I. Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine. Proc. Natl. Acad. Sci. USA. 84:1987;3004-3008.