Phase-based supervisory control for fermentation process development

Journal of Process Control

Volumn 13, Issue 5, 2003, Pages 367-382

  Muthuswamy, Kashyap ^a   Srinivasan, Rajagopalan ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Expert system; Fermentation; Pharmaceuticals; Process monitoring

Indexed keywords

CONTROL SYSTEM ANALYSIS; DRUG PRODUCTS; EXPERT SYSTEMS; MONITORING; NONLINEAR SYSTEMS; PROCESS ENGINEERING;

PROCESS DEVELOPMENT;

FERMENTATION;

EID: 0037411801     PISSN: 09591524     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-1524(02)00063-X     Document Type: Article

References (24)

1. Bonvin D. Optimal operation of batch reactors. J. Proc. Control. 8(5):1998.
2. Basu P.K. Pharmaceutical process development is different. Chem. Eng. Prog. 94(9):1998;75-82.
3. Hofmeister M., Halasz L., Rippin D.W. T Knowledge-based tools for batch processing systems. Comput. Chem. Eng. 13(11-12):1989;1255-1261.
4. International Society for measurement and control, ISA S88.01-1995: Batch control, part 1: models and terminology, 1995.
5. David R. Grafcet. a powerful tool for the specification of logic controllers, IEEE Trans Cont. Sys. Tech. 3(3):1995;253-268.
6. Konstantinov K.B., Yoshida T. Knowledge-based control of fermentation processes. Biotechnol. Bioeng. 39(5):1992;479-486.
7. Konstantinov K.B., Yoshida T. Real-time qualitative-analysis of the temporal shapes of (bio)process variables. AIChE J. 38(11):1992;1703-1715.
8. Konstantionov K.B., Zhou W., Golini F., Hu W.S. Expert systems in the control of animal cell culture processes. potentials, functions and perspectives Cytotechnology. 14:1994;233-246.
9. G.K., Raju. An intelligent approach to fermentation control, http://www.gensym.com/expert_operations/papers/gkrajune.htm, 2001.
10. Kitsuta Y., Kishimoto M. Fuzzy supervisory control of glutamic-acid production, June 5. Biotechnol Bioeng. 44(1):1994;87-94.
11. Honda H., Kobayashi T. Fuzzy control of bioprocess. J. Biosci. Bioeng. 89(5):2000;401-408.
12. Ignova M., Glassey J., Ward A.C., Montague G.A. Multivariate statistical methods in bioprocess fault detection and performance forecasting. Trans. Ins. Meas. Cont. 5(19):1997;271-279.
13. Shimizu H., Yasuoka K., Uchiyama K., Shioya S. Bioprocess fault detection by nonlinear multivariate analysis. application of an artificial autoassociative neural network and wavelet filter bank Biotech. Prog. (14):1998;79-87.
14. Lee J., Lee S.Y., Park S., Middleberg P.J. A Control of fed-batch fermentations, Biotechnol. Advances. 17(1):1999;29-48.
15. Dimassimo C., Willis M.J., Montague G.A., Tham M.T., Morris A.J. Bioprocess model-building using artificial neural networks. Bioproc. Eng. 7:(1-2):1991;77-82.
16. Chen W., Graham C., Ciccarelli R.B. Automated fed-batch fermentation with feed-back controls based on dissolved oxygen (DO) and pH for production of DNA vaccines. J. Ind. Microbiol. Biotechnol. 18(1):1997;43-48.
17. W. Chen. Automated high-yield fermentation of plasmid DNA in Escherichia coli, United States Patent, #5955323, 1999.
18. S.S. Lee, R.D. Mohler. Controlled growth rate fermentation, European Patent #315944A2, c/o Eastman Kodak Company, 1989.
19. Basu P.K., Quaadgras J., Mack R.A., Noren A.R. Achieve the right balance in pharmaceutical pilot plants. Chem. Eng. Prog. 94(2):1998;67-74.
20. Johnsson C., Arzen K.E. Grafchart for recipe-based batch control, Comput. Chem. Eng. 22:(12):1998;1811-1828.
21. K. Gollmer, C. Posten, Pattern recognition for phase detection in bioprocesses, IFAC Computer Applications in Biotechnology, Garmisch-Partenkirchen, 1995.
22. K. Muthuswamy, R. Srinivasan, Intelligent phase identification for monitoring batch processes, Presented at the Regional Symposium for Chemical Engineering, RSCE, Songkhla, Thailand, 1999.
23. K. Muthuswamy, R. Srinivasan, S.M. Bested, M. White. Automatic rule generation for supervision of fermentation processes, Presented at the 8th International Conference On Computer Applications In Biotechnology, Québec City, Canada, 24 - 27 June, 2001.
24. K. Muthuswamy, 2001. A feature recognition approach to automatic supervision of fermentation processes, M'Eng thesis, National University of Singapore, 2001.