Reduction of oral acetaldehyde levels using a controlled-release chlorhexidine chip as a prevention strategy against upper digestive tract cancer

Medical Hypotheses

Volumn 60, Issue 6, 2003, Pages 856-858

  Rota, M T ^a   Poggi, Paola ^a,b  

^a UNIVERSITY OF PAVIA   (Italy)

^b Dipartamento Medicina Sperimentale   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACETALDEHYDE; ALCOHOL; ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE; CARBOMER; CHLORHEXIDINE; FLUORIDE; HYDROXYPROPYLMETHYLCELLULOSE;

CANCER RISK; CONTROLLED RELEASE FORMULATION; DIGESTIVE SYSTEM CANCER; DRUG DELIVERY SYSTEM; HUMAN; MOUTH; MOUTH FLORA; MOUTHWASH; NONHUMAN; ORTHODONTIC DEVICE; OXIDATION; PATIENT COMPLIANCE; PRIORITY JOURNAL; SALIVA; SHORT SURVEY; UPPER GASTROINTESTINAL TRACT;

BACTERIA (MICROORGANISMS);

EID: 0037410428     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-9877(03)00063-X     Document Type: Short Survey

References (23)

1. Franceschi S., Talamini R., Barra S. et al. Smoking and drinking in relation to cancer of the oral cavity, pharynx, larynx and esophagus in Northern-Italy. Cancer Res 1990; 50: 6502-6507.
2. La Vecchia C., Tavani A., Franceschi S., Levi F., Corrao G., Negri E. Epidemiology and prevention of oral cancer. Oral Oncol 1997; 33: 302-312.
3. Castellsague X., Munoz N., De Stefani E. et al. Independent and joint effects of tobacco smoking and alcohol drinking on the risk of esophageal cancer in men and women. Int J Cancer 1999; 82: 657-664.
4. IARC: Alcohol drinking. IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans. vol. 44. Lyon: Iarc, 1988.
5. Homann N., Karkkainen P., Koivisto T., Nosova T., Jokelaimen K., Salaspuro M. Effects of acetaldehyde on cell regeneration and differentiation of the upper gastrointestinal tract mucosa. J Natl Cancer Inst 1997; 89: 1692-1697.
6. Vaikeivanen S., Tillonen J., Agarwal D. P., Srivastava N., Salaspuro M. High salivary acetaldehyde after a moderate dose of alcohol in ALDH2-deficient subjects: strong evidence for the local carcinogenic action of acetaldehyde. Alcohol Clin Exp Res 2000; 24: 873-877.
7. Homann N., Tillonen J., Meurman Jh. et al. Increased acetaldehyde levels in heavy drinkers and smokers:a microbiological approach to oral cavity cancer. Carcinogenesis 2000; 21: 663-668.
8. Risner C. H., Martin P. Quantitation of formaldehyde, acetaldehyde and acetone in sidestream cigarette smoke by high-performance liquid chromatography. J Chromatogr Sci 1994; 32: 76-82.
9. Yokoyama A., Muramatsu T., Ohmori T. et al. Alcohol-related cancers and aldehyde-dehydrogenase-2 in Japanese alcoholics. Carcinogenesis 1998; 19: 1383-1387.
10. Harty L. C., Caporaso N. E., Hayes R. B. et al. Alcohol dehydrogenase 3 genotype and risk of oral cavity and pharyngeal cancers. J Natl Cancer Inst 1997; 89: 1698-1705.
11. Homann N., Tillonen J., Rintamaki H., Salaspuro M., Lindquist C., Meurman J. H. Poor dental status increases acetaldehyde production from ethanol in saliva: a possible link to increased oral cancer risk among heavy drinkers. Oral Oncol 2001; 37: 153-158.
12. Homann N., Jousimies-Somer H., Joikelainen K., Heine R., Salaspuro M. High acetaldehyde levels in saliva after ethanol consumption: methodological aspects and pathogenetic implications. Carcinogenesis 1997; 18: 1739-1743.
13. Rota M. T., Poggi P., Rizzo S., Rodriguez y Baena R., Boratto R. Acetaldehyde produced by alcohol-containing mouthrinses affects HGF cytoskeleton. J Dent Res 2001; 80: 745.
14. Marquis R. E. Antimicrobial action of fluoride for oral bacteria. Can J Microbiol 1995; 41: 955-964.
15. Wade A., Weller P.J. (eds). Handbook of Pharmaceutical Excipients, 2nd Edn. London: The Pharmaceutical Press, 1994.
16. Hoffman T., Bruhn G., Richter S., Netuschil L., Brecx M. Clinical controlled study on plaque and gingivitis reduction under long-term use of low-dose chlorhexidine solutions in a population exhibiting good oral hygiene. Clin Oral Investig 2001; 5: 89-95.
17. Bonesvoll P. Retention and plaque inhibiting effect in man of chlorhexidine after multiple mouthrinses and retention and release after tooth-brushing with a chlorhexidine gel. Arch Oral Biol 1978; 23: 295-300.
18. Emilson C. G., Ericson T., Heyden G., Magnusson B. C. Uptake of chlorhexidine to hydroxyapatite. J Periodontal Res 1973; 8: 17-21.
19. Baker P. J., Coburn R. A., Genco R. J., Evans R. T. Structural determinants of activity of chlorhexidine and alkyl bisbiguanides against the human oral flora. J Dent Res 1987; 66: 1099-1106.
20. Ellepola A. N., Samaranayake L. P. Adjunctive use of chlorhexidine in oral candidoses: a review. Oral Dis 2001; 7: 11-17.
21. Maier H., Born I. A., Veith S., Adler D., Seitz H. K. The effect of chronic ethanol consumption on salivary gland morphology and function in rat. Alcohol Clin Exp Res 1986; 10: 425-427.
22. Maier H., Born I. A., Mall G. Effect of chronic ethanol and nicotine consumption on the function and morphology of the salivary glands. KlinWochenschr 1988; 66: 140-150.
23. Mombelli A., Nicopoulou-Karayianni K., Lang N. P. Local differences in the newly formed crevicular microbiota. Schweiz Monatsschr Zahnmed 1990; 100: 154-158.