Mode of anti-fungal activity of 1,10-phenanthroline and its Cu(II), Mn(II) and Ag(I) complexes

BioMetals

Volumn 16, Issue 2, 2003, Pages 321-329

  Coyle, Barry ^a   Kavanagh, Kevin ^a   McCann, Malachy ^a   Devereux, Michael ^b   Geraghty, Majella ^a  

^a NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^b DUBLIN INSTITUTE OF TECHNOLOGY   (Ireland)

Author keywords

1,10 phenanthroline; Anti fungal; Candida; Fungicidal; Fungistatic; Metal complexes

Indexed keywords

1,10 PHENANTHROLINE; 1,10 PHENANTHROLINE COPPER; 1,10 PHENANTHROLINE MANGANESE; 1,10 PHENANTHROLINE SILVER; METAL COMPLEX; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; COMPLEX FORMATION; FUNGICIDAL ACTIVITY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; YEAST;

ANTIFUNGAL AGENTS; CANDIDA ALBICANS; CELL RESPIRATION; COPPER; ERGOSTEROL; MANGANESE; MICROBIAL SENSITIVITY TESTS; ORGANOMETALLIC COMPOUNDS; PHENANTHROLINES; SILVER;

CANDIDA; CANDIDA ALBICANS;

EID: 0037409884     PISSN: 09660844     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1020695923788     Document Type: Article

References (24)

1. Abu Salah KM. 1996 Amphotericin B: an update. Brit J Biomed Sci 53, 122-133.
2. Arthington-Skaggs BA, Jradi H, Desai T, Morrison CJ. 1999 Quantitation of ergosterol content: novel method for determination of fluconazole susceptibility of Candida albicans. J Clin Microbiol 37, 3332-3337.
3. 2O (phen = 1,10-phenanthroline). Polyhedron 14, 2247-2253.
4. Daum G, Lees ND, Bard M, Dickson R. 1998 Biochemistry, cell biology and molecular biology of lipids of Saccharomyces cerevisiae. Yeast 14, 1471-1510.
5. Dening DW, Evans EG, Kibbler CC. et al. 1997 Guidelines for the investigation of invasive fungal infections in haematological malignancy and solid organ transplantation. Eur J Clin Microbiol Infect Dis 16, 424-436.
6. 2 = fumaric acid; bipy = 2,2′-bipyridine; phen = 1,10-phenanthroline). Polyhedron 19, 1205-1211.
7. 2 = phthalic acid; Isoph = isophthalic acid; Phen = 1,10-phenanthroline; bipy = 2,2-bipyridine). Metal-Based Drugs 7, 275-288.
8. 2O (phen = 1,10-phenanthroline). Metal-Based Drugs 6, 41-48.
9. 2 = cis-5-norbornene-endo-2,3-dicarboxylic acid; bipy = 2,2′-bipyridine; phen = 1,10-phenanthroline). Polyhedron 18, 2931-2939.
10. 2O (phen = 1,10-phenanthroline). Inorg Chim Acta 293, 160-166.
11. Geraghty M, Cronim JF, Devereux M, McCann M. 2000 Synthesis and antimicrobial activity of copper(II) and manganese(II) α,ω-dicarboxylate complexes. BioMetals 13, 1-8.
12. Hye-Jin K, Byoung-Kuk N, Moon-Bo K. et al. 1999 Protective effects of antioxidant enzymes of Candida albicans against oxidative killing by macrophages. J Microbiol 117-122.
13. Klepser ME, Ernst EJ, Pfaller MA. 1997 Update on anti-fungal resistance. Trends Microbiol 5, 372-375.
14. Lunel FMV, Meis J, Voss A. 1999 Nosocomial fungal infections. Candidemia. Diagn Microbiol Infect Dis 34, 213-220.
15. 2) (phen = 1,10-phenanthroline). Polyhedron 14, 2379-2387.
16. McCann M, Geraghty M, Devereux M. et al. 2000 Insights into the mode of action of the anti-Candida activity of 1,10-phenanthroline and its metal chelates. Metal-Based Drugs 7, 185-193.
17. Moran GP, Sanglard D, Donnelly SM, Shanley D, Sullivan DJ, Colemen DC. 1998 Identification and expression of multi-drug transporters responsible for fluconazole resistance in Candida dubliniensis. Antimicrob Agent Chemother 42, 1819-1830.
18. Moussa NM, Ghannoum MA, Whittaker PA, El-Ezaby MS, Quraman S. 1990 Effects of cisplatin and two novel palladium complexes on Candida albicans, Microbios 62, 165-178.
19. Odds FC. 1996 Resistance of clinically important yeasts to antifungal agents. Int J Antimicrob Agent 6, 145-147.
20. Panimon F, Horwitt MK, Gerard RW. 1941 Orthophenanthroline as accelerator of brain tissue oxygen consumption. J Cell Comp Physiol 17, 17-29.
21. Pfaller MA, Jones RN, Messer SA, Edmond MB, Wenzel RP. 1998 National surveillance of nosocomial blood stream infection due to Candida albicans: frequency of occurrence and anti-fungal susceptibility in the SCOPE program. Diagn Microbiol Infect Dis 31, 327-332.
22. Reeves E, Kavanagh K, Whitaker PA. 1991 Cupferron - a novel petite inducing agent in yeast. Biomed Letts 46, 253-257.
23. Whittaker PA and Danks SM. 1978 Mitochondria: Structure, Function and Assembly. Integrated Themes in Biology. London: Longman.
24. Wirsching S, Michel S, Kohler G, Morschhauser J. 2000 Activation of the multiple drug resistance gene MDR1 in fluconazole resistant clinical Candida albicans strains is caused by mutations in a trans-regulatory factor. J Bacteriol 182, 400-404.