A modeling study predicts the presence of voltage gated Ca2+ channels on myelinated central axons

Computer Methods and Programs in Biomedicine

Volumn 71, Issue 1, 2003, Pages 25-31

  Brown, Angus M ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Action potential; Hodgkin Huxley model; ICa; Nifedipine; Simulation

Indexed keywords

CALCIUM; COMPUTER SIMULATION; ELECTRIC POTENTIAL; LEAKAGE CURRENTS;

RAT OPTIC NERVES (RON);

BIOMEDICAL ENGINEERING;

CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; NIFEDIPINE;

ACTION POTENTIAL; ARTICLE; CALCIUM CURRENT; COMPARTMENT MODEL; COMPUTER SIMULATION; CONTROLLED STUDY; ELECTRIC POTENTIAL; EVOKED RESPONSE; HODGKIN HUXLEY EQUATION; MYELINATED NERVE; NERVE EXCITABILITY; NONHUMAN; OPTIC NERVE; PREDICTION; RAT; REPOLARIZATION;

ACTION POTENTIALS; ANIMALS; AXONS; CALCIUM CHANNELS; COMPUTER SIMULATION; ELECTRIC STIMULATION; ION CHANNEL GATING; MEMBRANE POTENTIALS; MODELS, BIOLOGICAL; NERVE FIBERS, MYELINATED; OPTIC NERVE; RATS; RATS, LONG-EVANS;

EID: 0037407678     PISSN: 01692607     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-2607(02)00031-7     Document Type: Article

References (28)

1. Brown A.M. A methodology for simulating biological systems using Microsoft Excel. Comp. Meth. Prog. Biomed. 58:1999;181-190.
2. Brown A.M. Simulation of axonal excitability using a spreadsheet template created in Microsoft Excel. Comp. Meth. Prog. Biomed. 63:2000;47-54.
3. Fern R., Ransom B.R., Waxman S.G. Voltage-gated calcium channels in CNS white matter; role in anoxic injury. J. Neurophysiol. 74:1995;369-377.
4. Foster R.E., Connors B.W., Waxman S.G. Rat optic nerve: electrophysiological, pharmacological and anatomical studies during development. Dev. Brain Res. 3:1982;371-386.
5. Stys P.K. Anoxic and ischemic injury of myelinated axons in CNS white matter; From mechanistic concepts to therapeutics. J. Cereb. Blood Flow Metab. 18:1998;2-25.
6. Kriegler S., Chiu S.Y. Calcium signaling of glial cells along mammalian axons. J. Neurosci. 13:1993;4229-4245.
7. Lev-Ram V., Grinvald A. Activity-dependent calcium transients in central nervous system myelinated axons revealed by the calcium indicator Fura-2. Biophys. J. 52:1987;571-576.
8. B receptors in axons of neonatal rat optic nerve. J. Neurosci. 19:1999;5185-5194.
9. Stys P.K., Ransom B.R., Waxman S.G. Effects of polyvalent cations and dihydropyridine calcium channel blockers on recovery of CNS white matter from anoxia. Neurosci. Lett. 115:1990;293-299.
10. Elliott P., Marsh S.J., Brown D.A. Inhibition of Ca-spikes in rat preganglionic cervical sympathetic nerves by sympathomimetic amines. Br. J. Pharmacol. 96:1989;65-76.
11. 2+ transients in unmyelinated nerve fibres of the isolated adult rat vagus nerve. Pflügers. Archiv. 435:1998;678-686.
12. Callewaert G., Eilers J., Konnerth A. Axonal calcium entry during fast 'sodium' action potentials in rat cerebellar Purkinje neurones. J. Physiol. 495:1996;641-647.
13. Scholfield C.N. Presynaptic Na/Ca action potentials in unmyelinated axons of olfactory cortex. Pflügers. Archiv. 411:1988;180-187.
14. 2+ channels and anoxic injury in rat CNS white matter. J. Neurophysiol. 85:2001;900-911.
15. Brown A.M., Wender R., Ransom B.R. Ionic mechanisms of aglycemic axon injury in mammalian central white matter. J. Cereb. Blood Flow Met. 21:2001;385-395.
16. Hodgkin A.L., Huxley A.F. A quantitative description of membrane current and its application to conduction and excitation in nerve. J. Physiol. 117:1952;500-544.
17. + conductances in rat neocortical neurons: appearance of a slowly inactivating component. J. Neurophysiol. 59:1988;778-795.
18. McCormick D.A., Huguenard J.R. A model of the electrophysiological properties of thalamocortical relay neurons. J. Neurophysiol. 68:1992;1384-1400.
19. Hille B. Ionic Channels of Excitable Membranes. 2001;Sinauer Associates Inc, Sunderland, MA, USA.
20. Kay A.R., Wong R.K. Calcium current activation kinetics in isolated pyramidal neurones of the CA1 region of the mature guinea-pig hippocampus. J. Physiol. 392:1987;603-616.
21. McCormick D.A., Prince D.A. Post-natal development of electrophysiological properties of rat cerebral cortical pyramidal neurones. J. Physiol. 393:1987;743-762.
22. Huguenard J.P., McCormick D.A. Electrophysiology of the Neuron: An Interactive Tutorial. 1994;Oxford University Press, New York.
23. Cummins K.L., Perkel D.H., Dorfman L.J. Nerve fiber conduction-velocity distributions. I. Estimation based on the single-fiber and compound action potentials. Electroencephalogr. Clin. Neurophysiol. 46:1979;634-646.
24. Leppanen L., Stys P.K. Ion transport and membrane potential in CNS myelinated axons. II. Effects of metabolic inhibition. J. Neurophysiol. 78:1997;2095-2107.
25. + conductance in rat optic nerve axons. Proc. Natl. Acad. Sci. USA. 90:1993;6976-6980.
26. + channels by calmodulin. Circ. Res. 90:2002;E49-E57.
27. 2+ channels. J. Biol. Chem. 276:2001;30794-30802.
28. Hardingham G.E., Chawla S., Johnson C.M., Bading H. Distinct functions of nuclear and cytoplasmic calcium in the control of gene expression. Nature. 385:1997;260-265.