Patients' willingness to participate in symptom-related and disease-modifying research: Results of a research screening initiative in a palliative care clinic

Cancer

Volumn 97, Issue 9, 2003, Pages 2327-2333

  Crowley, Roxane ^a   Casarett, David ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Cancer; Informed consent; Palliative care; Symptom management; Terminal illness

Indexed keywords

ADULT; AGE; AGED; ARTICLE; CANCER CENTER; CONTROLLED STUDY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL RESEARCH; OUTPATIENT DEPARTMENT; PALLIATIVE THERAPY; PATIENT ATTITUDE; PATIENT SELECTION; PRIORITY JOURNAL; QUESTIONNAIRE; RACE; SCORING SYSTEM; SCREENING; SYMPTOMATOLOGY; TERMINAL DISEASE;

ADULT; AGED; AGED, 80 AND OVER; BIOMEDICAL RESEARCH; FEMALE; HUMANS; INFORMED CONSENT; MALE; MIDDLE AGED; NEOPLASMS; PALLIATIVE CARE; PATIENT PARTICIPATION; QUESTIONNAIRES; STRESS, PSYCHOLOGICAL;

EID: 0037403997     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/cncr.11329     Document Type: Article

References (26)

1. Corner J. Is there a research paradigm for palliative care? Palliat Med. 1996;10:201-208.
2. Dhaliwal HS, Sloan P, Arkinstall WW, et al. Randomized evaluation of controlled-release codeine and placebo in chronic cancer pain. J Pain Sympt Manage. 1995;10:612-623.
3. Farrar JT, Cleary J, Rauck R, Busch M, Nordbrock E. Oral transmucosal fentanyl citrate: randomized, double-blinded, placebo-controlled trial for treatment of breakthrough pain in cancer patients. J Natl Cancer Inst. 1998;90:611-616.
4. Polati E, Finco G, Gottin L, Bassi C, Pederzoli P, Ischia S. Prospective randomized double-blind trial of neurolytic coeliac plexus block in patients with pancreatic cancer. Br J Surg. 1998;85:199-201.
5. Elliott TE, Murray DM, Oken MM, et al. Improving cancer pain management in communities: main results from a randomized controlled trial. J Pain Sympt Manage. 1997;13:191-203.
6. de Wit R, van Dam F, Zandbelt L, et al. A pain education program for chronic cancer pain patients: follow-up results from a randomized controlled trial. Pain. 1997;73:55-69.
7. Kravitz RL, Delafield JP, Hays RD, Drazin R, Conolly M. Bedside charting of pain levels in hospitalized patients with cancer: a randomized controlled trial. J Pain Sympt Manage. 1996;11:81-87.
8. Du Pen SL, Du Pen AR, Polissar N, et al. Implementing guidelines for cancer pain management: results of a randomized controlled clinical trial. J Clin Oncol. 1999;17:361-370.
9. Bredin M, Corner J, Krishnasamy M, Plant H, Bailey C, A'Hern R. Multicentre randomised controlled trial of nursing intervention for breathlessness in patients with lung cancer. BMJ. 1999;318:901-904.
10. Casarett DJ, Karlawish J, Sankar P, Hirschman K, Asch DA. Obtaining informed consent for cancer pain research: do patients with advanced cancer and patients with chronic pain have different concerns? J Pain Sympt Manage. 2002; 24:506-516.
11. Ling J, Rees E, Hardy J. What influences participation in clinical trials in palliative care in a cancer centre? Eur J Cancer. 2000;36:621-626.
12. Meinert CL. Clinical trials. Design, conduct, and analysis. Oxford: Oxford University Press, 1986.
13. Casarett DJ. Research ethics. In: Berger A, Portenoy RDW, editors. Principles and practice of palliative care and supportive oncology (2nd edition). Philadelphia: Lippincott Williams & Wilkins, 2002:1131-1140.
14. Casarett D, Kirschling J, Levetown M, Merriman M, Ramey M, Silverman P. NHPCO task force statement on hospice participation in research. J Palliat Med. 2001;4:441-449.
15. Casarett D, Karlawish J. Are special ethical guidelines needed for palliative care research? J Pain Sympt Manage. 2000;20:130-139.
16. Casarett D, Coffey J, Hirschman K, Pierre L. Does a palliative care clinic have a role in improving end-of-life care? J Palliat Med. 2002;5:387-396.
17. Portenoy RK, Thaler HT, Kornblith AB, et al. The Memorial Symptom Assessment Scale: an instrument for the evaluation of symptom prevalence, characteristics and distress. Eur J Cancer. 1994;30A:1326-1336.
18. Orr ST, Aisner J. Performance status assessment among oncology patients. A review. Cancer Treat Rep. 1986;70:1423-1429.
19. Mickey J, Greenland S. A study of the impact of confounder selection criteria on effect estimation. Am J Epidemiol. 1989; 129:125-137.
20. Hosmer DW, Lemeshow S. Applied logistic regression. New York: John Wiley and Sons, 1989.
21. Hunter CP, Frelick RW, Feldman AR, et al. Selection factors in clinical trials. Cancer Treat Rep. 1987;71:559-565.
22. Fetting JH, Simenoff LA, Piantadosi S, Abeloff MD, Damron DJ, Sarsfield AM. Effect of patients' expectations of benefit with standard breast cancer adjuvant chemotherapy on participation in a randomized clinical trial: a clinical vignette study. J Clin Oncol. 1990;8:1476-1482.
23. Hunt R, Fazekas B, Thorne D, Brooksbank M. A comparison of subcutaneous morphine and fentanyl in hospice cancer patients. J Pain Sympt Manage. 1999;18:111-119.
24. Lara PM, Higdon R, Lim N, et al. Prospective evaluation of cancer clinical trial accrual patterns: identifying potential barriers to enrollment. J Clin Oncol. 2001;19:1728-1733.
25. Jack WJ, Chetty U, Rodger A. Recruitment to a prospective breast conservation trial: why are so few patients randomized? BMJ. 1990;301:83-85.
26. Klabunde CN, Springer BC, Butler B, White MS, Atkins J. Factors influencing enrollment in clinical trials for cancer treatment. South Med J. 1999;92:1189-1193.