A study of the toxicity of five mineral hydrocarbon waxes and oils in the F344 rat, with histological examination and tissue-specific chemical characterisation of accumulated hydrocarbon material

Food and Chemical Toxicology

Volumn 41, Issue 4, 2003, Pages 489-521

  Scotter, M J ^a   Castle, L ^a   Massey, R C ^a   Brantom, P G ^b   Cunninghame, M E ^b  

^a CENTRAL SCIENCE LABORATORY   (United Kingdom)

^b TNO BIBRA International Ltd   (United Kingdom)

Author keywords

Chemical analysis; Mineral hydrocarbons; Oral administration; Rats; Tissue accumulation; Toxicity study

Indexed keywords

ALKANE; HYDROCARBON; MINERAL HYDROCARBON; OIL; UNCLASSIFIED DRUG; WAX;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CHEMICAL ANALYSIS; CONTROLLED STUDY; DIET; FECES LEVEL; FEMALE; HEART; HISTOPATHOLOGY; KIDNEY; LIVER LEVEL; LYMPH NODE; MELTING POINT; NONHUMAN; RAT; SMALL INTESTINE; TISSUE DISTRIBUTION; TISSUE SPECIFICITY; TOXICITY; URINE LEVEL;

ANIMALS; BODY WEIGHT; CHROMATOGRAPHY, GAS; DIET; EATING; FECES; FEMALE; HYDROCARBONS; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; OILS; ORGAN SIZE; QUALITY CONTROL; RATS; RATS, INBRED F344; REPRODUCIBILITY OF RESULTS; TISSUE DISTRIBUTION; WAXES;

EID: 0037399731     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-6915(02)00279-X     Document Type: Article

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