How well can a T-cell epitope replace its parent carrier protein? A dose-response study

Pharmaceutical Research

Volumn 20, Issue 4, 2003, Pages 591-596

  Cavenaugh, James S ^a   Wang, Hsu Kun ^a   Hansen, Cory ^a   Smith, Richard S ^a   Herron, James N ^a  

^a UNIVERSITY OF UTAH   (United States)

Author keywords

Chicken hen egg lysozyme; Dose reponse; Fluorescein hapten; HEL; MAP; Multiple antigenic peptide; T cell epitope

Indexed keywords

[FLUORESCEIN (18 GLYCINE)]MULTIPLE ANTIGENIC PEPTIDE; [FLUORESCEIN (T CELL EPITOPE)]MULTIPLE ANTIGENIC PEPTIDE; CARRIER PROTEIN; EPITOPE; FLUORESCEIN; FLUORESCEIN (T CELL EPITOPE); FLUORESCEIN HEN EGG LYSOZYME; LYSOZYME; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DOSE RESPONSE; DRUG POTENCY; DRUG PROTEIN BINDING; IMMUNE RESPONSE; MALE; MOLECULAR MIMICRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; ANTIGENS; CARRIER PROTEINS; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES, T-LYMPHOCYTE; FLUORESCEIN; IMMUNODOMINANT EPITOPES; MALE; MICE; MURAMIDASE; PEPTIDES;

EID: 0037394347     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1023242631413     Document Type: Article

References (25)

1. K. F. Hu, K. Lovgren-Bengtsson, and B. Morein. Immunostimulating complexes (ISCOMs) for nasal vaccination. Adv. Drug Deliv. Rev. 23:149-159 (2001).
2. R. Langer, J. L. Cleland, and J. Hanes. New advances in microsphere-based single-dose vaccines. Adv. Drug Delivery Rev. 28: 97-119 (1997).
3. A. Sjolander, D. Drane, E. Maraskovsky, J. Scheerlinck, A. Suhrbier, J. Tennent, and M. Pearse. Immune responses to ISCOM formulations in animal and primate models. Vaccine 19:2661-2665 (2001).
4. D. T. O'Hagan, M. L. MacKichan, and M. Singh. Recent developments in adjuvants for vaccines against infectious diseases. Biomol. Eng. 18:69-85 (2001).
5. J. P. Tam. Synthetic peptide vaccine design: Synthesis and properties of a high-density multiple antigenic peptide system. Proc. Natl. Acad. Sci. USA 85:5409-5413 (1988).
6. Y.-A. Lu, P. Clavijo, M. Galantino, Z.-Y. Shen, W. Liu, and J. P. Tam. Chemically unambiguous peptide immunogen: preparation, orientation and antigenicity of purified peptide conjugated to the multiple antigen peptide system. Mol. Immunol. 28:623-630 (1991).
7. G. W. McLean, A. M. Owsianka, J. H. Subak-Sharpe, and H. S. Marsden. Generation of anti-peptide and anti-protein sera. Effect of peptide presentation on immunogenicity. J. Immunol. Methods 137:149-157 (1991).
8. J. P. Tam, P. Clavijo, Y.-A. Lu, V. Nussenzweig, R. Nussenzweig, and F. Zavala. Incorporation of T and B epitopes of the circumsporozoite protein in a chemically defined synthetic vaccine against malaria. J. Exp. Med. 171:299-306 (1990).
9. D. Y. Munesinghe, P. Clavijo, M. C. Calle, R. S. Nussenzweig, and E. Nardin. Immunogenicity of multiple antigen peptides (MAP) containing T and B cell epitopes of the repeat region of the P. falciparum circumsporozoite protein. Eur. J. Immunol. 21: 3015-3020 (1991).
10. S. K. Chai, P. Clavijo, J. P. Tam, and F. Zavala. Immunogenic properties of multiple antigenic peptide systems containing defined T and B epitopes. J. Immunol. 149:2385-2390 (1992).
11. J.-P. Briand, C. Barin, M. H. V. Van Regenmortel, and S. Muller. Application and limitations of the multiple antigen peptide (MAP) system in the production and evaluation of anti-peptide and anti-protein antibodies. J. Immunol. Methods 156:255-265 (1992).
12. M. J. Francis, G. Z. Hastings, F. Brown, J. McDermed, Y.-A. Lu, and J. P. Tam. Immunological evaluation of the multiple antigen peptide (MAP) system using the major immunogenic site of foot-and-mouth disease virus. Immunology 73:249-254 (1991).
13. E. W. Voss, Jr. Fluorescein Hapten: An Immunological Probe, CRC Press, Boca Raton, Florida, 1984, p. 193.
14. S. J. Smith-Gilland and E. E. Sercarz. The Immune Response to Structurally Defined Proteins: The Lysozyme Model, Adenine Press. Schenectady, New York, 1989, p. 416.
15. G. Gammon, H. M. Geysen, R. J. Apple, E. Pickett, M. Palmer, A. Ametani, and E. E. Sercarz. T cell determinant structure: cores and determinant envelopes in three mouse major histocompatibility complex haplotypes. J. Exp. Med. 173:609-617 (1991).
16. E. Harlow and D. Lane. Antibodies: A Laboratory Manual, Cold Spring Harbor Laboratory, New York. 1988.
17. H. H. Keah, E. Kecorius, and M. T. W. Hearn. Direct synthesis and characterisation of multi-dendritic peptides for use as immunogens. J. Pept. Res. 51:2-8 (1998).
18. D. M. Kranz and E. W. Voss, Jr. Production and purification of antifluorescyl antibodies. In E. W. Voss, Jr. (ed.), Fluorescein Hapten: An Immunological Probe, CRC Press, Boca Raton, Florida, 1984, pp. 15-20.
19. O. P. Bormer. Interference of complement with the binding of carcinoembryonic antigen to solid-phase monoclonal antibodies. J. Immunol. Methods 121:85-93 (1989).
20. A. Larsson, P. E. Wejaker. P. O. Forsberg, and T. Lindahl. Chicken antibodies: a tool to avoid interference by complement activation in ELISA. J. Immunol. Methods 156:79-83 (1992).
21. D. Carlander and A. Larsson. Avian antibodies can eliminate interference due to complement activation in ELISA. Ups. J. Med. Sci. 106:189-195 (2001).
22. A. K. Abbas, A. H. Lichtman, and J. S. Pober. Cellular and Molecular Immunology, W.B. Saunders, Philadelphia, Pennsylvania, 1997.
23. N. Bercovici, J. Delon, C. Cambouris, N. Escriou, P. Debre, and R. S. Liblau. Chronic intravenous injections of antigen induce and maintain tolerance in T cell receptor-transgenic mice. Eur. J. Immunol. 29:345-354 (1999).
24. A. M. Mowat, M. Steel, E. A. Worthey, P. J. Kewin, and P. Garside. Inactivation of Th1 and Th2 cells by feeding ovalbumin. Ann. NY Acad. Sci. 778:122-132 (1996).
25. M. A. Fishman and A. S. Perelson. Lymphocyte memory and affinity selection. J. Theor. Biol. 173:241-262 (1995).