Limitations of in silico predictability of specificity of co-immobilised cytochromes P450 and mimics in food-bioprocessing

Biotechnology Letters

Volumn 25, Issue 7, 2003, Pages 515-519

  Wiseman, Alan ^a  

^a UNIVERSITY OF SURREY   (United Kingdom)

Author keywords

Cytochromes P450; Enzyme mimics; Enzymes; Food bioprocessing; Immobilised enzymes

Indexed keywords

CARCINOGEN; CYTOCHROME P450; CYTOCHROME P450 1A1; FLAVORING AGENT; FOOD ADDITIVE; IMMOBILIZED ENZYME; REACTIVE OXYGEN METABOLITE;

BIOTECHNOLOGY; CHEMISTRY; ENZYME SPECIFICITY; FOOD HANDLING; METABOLISM; METHODOLOGY; MOLECULAR MIMICRY; OXIDATION REDUCTION REACTION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REVIEW;

BIOTECHNOLOGY; CARCINOGENS; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 ENZYME SYSTEM; ENZYMES, IMMOBILIZED; FLAVORING AGENTS; FOOD ADDITIVES; FOOD HANDLING; MOLECULAR MIMICRY; OXIDATION-REDUCTION; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; REACTIVE OXYGEN SPECIES; SUBSTRATE SPECIFICITY;

EID: 0037388484     PISSN: 01415492     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1022824015304     Document Type: Review

References (17)

1. Abele D (2002) The radical life-giver. Nature 420: 27.
2. Altamirano M, Blackburn J, Aguayo C, Fersht A (2000) Directed evolution of new catalytic activity using the α/β-barrel scaffold. Nature 403: 617-622.
3. Halliwell B, Gutteridge JMC (1999) Free Radicals in Biology and Medicine, 3rd edn. Oxford, UK: Clarendon Press.
4. Lane N (2002) Oxygen: The Molecule that Made the World. Oxford, UK: Oxford University Press.
5. Lewis D (2001) Guide to Cytochromes P450 Structure and Function. London, UK: Taylor & Francis.
6. Mottram DS, Wedzicha BL, Dodson AT (2002) Acrylamide is formed in the Maillard reaction. Nature 419: 448-449.
7. Palmer T (2001) Enzymes: Biochemistry, Biotechnology, Clinical Chemistry. Chichester, UK: Horwood Publishing.
8. Schultz RG, Lerner M (2002) Completing the circle. Nature 418: 485.
9. Stadler RH, Blank I, Varga N, Roberts MC, Han J, Guy P, Riedker S, Roberts MC (2002) Acrylamide from Maillard reaction products. Nature 419: 449.
10. Tucker G, Woods LFJ (1997) Enzymes in Food Processing, 2nd edn. Glasgow, Scotland, UK: Blackie & Sons.
11. Wiseman A, ed. (1995) Handbook of Enzyme Biotechnology, 3rd edn. Hemel Hempstead, UK: Ellis Horwood (Prentice Hall).
12. Wiseman A (2003) Do unpredictable toxic side effects of drugs reflect their promiscuous binding energies? Trends Pharmacol. Sci. (in press).
13. Wiseman A, Woods LFJ (2002a) Can 'real-lab' supersede 'virtual-ligand' promises?. Trends Pharmacol. Sci. 23: 261.
14. Wiseman A, Woods LFJ (2002b) Welcome praise for copper. Chem. Britain 38: 20.
15. Wiseman H, Goldfarb P, Ridgway T, Wiseman A (2000) Biomolecular Free Radical Toxicity: Causes and Prevention. Chichester, UK: John Wiley & Sons.
16. Wiseman A, Lewis D, Ridgway T, Wiseman H (2000) Cytochromes P-450 in food-processing: limitations of imitations. J. Chem. Technol. Biotechnol. 75: 3-5.
17. Wiseman A, Ridgway TJ, Goldfarb P, Woods LFJ (2002) Are food and environmental toxicants 'overdetected' by bioassay? Trends Biotechnol. 20: 13-15.