Study on the association of lecithin cholesterol acyltransferase gene polymorphisms with the lipid metabolism in coronary atherosclerotic heart disease

Chinese Journal of Medical Genetics

Volumn 20, Issue 2, 2003, Pages 135-137

  Zhang, Ke lan ^a   Zhang, Si zhong ^a   Zheng, Ke qin ^a   He, Yong ^a   Zhang, Li ^a   Su, Zhi guang ^a   Sun, Yan ^a   Shi, Jia jun ^a   Kong, Xiang dong ^a   Tong, Yu ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Coronary atherosclerotic heart disease; Lecithin cholesterol acyltransferase gene; Serum lipid; Single nucleotide polymorphism

Indexed keywords

GENES; LIPIDS; METABOLISM; PATIENT TREATMENT;

POLYMORPHISM;

GENETIC ENGINEERING;

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; PHOSPHATIDYLCHOLINE STEROL ACYLTRANSFERASE;

ADULT; AGED; ALLELISM; ARTICLE; BINDING SITE; CHINESE; CHOLESTEROL BLOOD LEVEL; CLINICAL OBSERVATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORONARY ARTERY ATHEROSCLEROSIS; ENZYME ANALYSIS; EQUILIBRIUM CONSTANT; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HARDY WEINBERG DISTRIBUTION LAW; HUMAN; ISCHEMIC HEART DISEASE; LCAT GENE; LIPID METABOLISM; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; POPULATION DYNAMICS; PROTEIN LOCALIZATION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; STATISTICAL SIGNIFICANCE;

ALLELES; CHINA; CHOLESTEROL; CHOLESTEROL, HDL; CHOLESTEROL, LDL; CHOLESTEROL, VLDL; CORONARY ARTERIOSCLEROSIS; DNA; DNA RESTRICTION ENZYMES; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; LIPID METABOLISM; LIPIDS; MALE; MIDDLE AGED; PHOSPHATIDYLCHOLINE-STEROL O-ACYLTRANSFERASE; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; TRIGLYCERIDES;

EID: 0037388331     PISSN: 10039406     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. Lusis AJ. Atherosclerosis. Nature, 2000, 407: 233-241.
2. Jonas A. Lecithin cholesterol acyltransferase. Biochim Biophys Acta, 2000, 1529: 245-256.
3. Cargill M, Altshuler D, Ireland J, et al. Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nat Genet, 1999, 22: 231-238.
4. Recalde D, Cenarro A, Civeira F, et al. A novel DNA polymorphism (4886C > T) in the human LCAT gene. Hum Mutat, 2000, 15: 298-299.
5. Kuivenhoven JA, Stalenhoef AFH, Hill JS, et al. Two novel molecular defects in the LCAT gene are associated with fish eye disease. Arterioscler Thromb Vasc Biol, 1996, 16: 294-303.
6. Tall AR. Plasma high density lipoproteins. Metabolism and relationship to atherogenesis. J Clin Invest, 1990, 86: 379-384.
7. Gordon DJ, Rifkind BM. High density lipoproteins-the clinical implications of recent studies. New Engl J Med, 1989, 321: 1311-1316.
8. Stocks J, Cooke CJ, Miller NE. A common lecithin cholesterol acyltransferase gene variant (Ser208-Thr). Atherosclerosis, 2000, 149: 219-220.