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Volumn 141, Issue 4, 2003, Pages 250-256

Residual effects of lovastatin and simvastatin on urinary mevalonate excretions in patients with familial hypercholesterolemia

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MEVALONIC ACID; MEVINOLIN; SIMVASTATIN;

EID: 0037388219     PISSN: 00222143     EISSN: None     Source Type: Journal    
DOI: 10.1067/mlc.2003.31     Document Type: Article
Times cited : (9)

References (37)
  • 1
    • 0027199627 scopus 로고
    • Therapeutic use of lovastatin in the treatment of hypercholesterolemia
    • Illingworth DR. Therapeutic use of lovastatin in the treatment of hypercholesterolemia. Drugs of Today 1993;2:201-16.
    • (1993) Drugs of Today , vol.2 , pp. 201-216
    • Illingworth, D.R.1
  • 2
    • 0028096810 scopus 로고    scopus 로고
    • A review of clinical trials comparing HMG CoA reductase inhibitors
    • Illingworth DR, Tobert JA. A review of clinical trials comparing HMG CoA reductase inhibitors. Clin Ther 1997;16:366-85.
    • (1997) Clin Ther , vol.16 , pp. 366-385
    • Illingworth, D.R.1    Tobert, J.A.2
  • 3
    • 0025022375 scopus 로고
    • Pravastatin therapy in primary moderate hypercholesterolemia: Changes in metabolism of apo-B containing lipoproteins
    • Vega GL, Krauss RM, Grundy SM. Pravastatin therapy in primary moderate hypercholesterolemia: changes in metabolism of apo-B containing lipoproteins. J Intern Med 1990;227:81-94.
    • (1990) J Intern Med , vol.227 , pp. 81-94
    • Vega, G.L.1    Krauss, R.M.2    Grundy, S.M.3
  • 4
    • 0000716338 scopus 로고
    • Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoproteins from plasma in familial hypercholesterolemia heterozygotes
    • Bilheimer DW, Grundy SM, Brown MS, Goldstein JL. Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoproteins from plasma in familial hypercholesterolemia heterozygotes. Proc Natl Acad Sci U S A 1983;80:4124-8.
    • (1983) Proc Natl Acad Sci U S A , vol.80 , pp. 4124-4128
    • Bilheimer, D.W.1    Grundy, S.M.2    Brown, M.S.3    Goldstein, J.L.4
  • 5
    • 0025345666 scopus 로고
    • Lovastatin therapy reduces low density lipoprotein apo B levels in subjects with combined hyperlipidemia by reducing the production of apo B containing lipoproteins: Implications for the pathophysiology of apo B production
    • Arad Y, Ramakrishnan R, Ginsberg HN. Lovastatin therapy reduces low density lipoprotein apo B levels in subjects with combined hyperlipidemia by reducing the production of apo B containing lipoproteins: implications for the pathophysiology of apo B production. J Lipid Res 1990;31:567-82.
    • (1990) J Lipid Res , vol.31 , pp. 567-582
    • Arad, Y.1    Ramakrishnan, R.2    Ginsberg, H.N.3
  • 6
    • 0021473810 scopus 로고
    • Effects of compactin on the levels of 3-hydroxy-3 methylglutaryl coenzyme A reductase in compactin resistant C100 and wild-type cells
    • Hardeman EC, Endo A, Simoni RD. Effects of compactin on the levels of 3-hydroxy-3 methylglutaryl coenzyme A reductase in compactin resistant C100 and wild-type cells. Arch Biochem Biophys 1984;22:549-61.
    • (1984) Arch Biochem Biophys , vol.22 , pp. 549-561
    • Hardeman, E.C.1    Endo, A.2    Simoni, R.D.3
  • 7
    • 0021985646 scopus 로고
    • Mechanism of 3-hydroxy-3 methylglutaryl coenzyme A reductase over-accumulation in the compactin-resistant cell lines
    • Shalnick DG, Brown DA, Brown PC, Friedman RL, Hardeman EC, Schimke RT, et al. Mechanism of 3-hydroxy-3 methylglutaryl coenzyme A reductase over-accumulation in the compactin-resistant cell lines. J Biol Chem 1985;260:1991-4.
    • (1985) J Biol Chem , vol.260 , pp. 1991-1994
    • Shalnick, D.G.1    Brown, D.A.2    Brown, P.C.3    Friedman, R.L.4    Hardeman, E.C.5    Schimke, R.T.6
  • 8
    • 0020571671 scopus 로고
    • Inhibition of degradation of 3-hydroxy-3 methylglutaryl coenzyme A reductase by mevinolin
    • Sinensky M, Logel J. Inhibition of degradation of 3-hydroxy-3 methylglutaryl coenzyme A reductase by mevinolin. J Biol Chem 1983;258:8547-9.
    • (1983) J Biol Chem , vol.258 , pp. 8547-8549
    • Sinensky, M.1    Logel, J.2
  • 9
    • 0020463703 scopus 로고
    • The effects of cholestyramine and mevinolin on the diurnal cycle of rat hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase
    • Tanaka RD, Edwards PA, Lan S-F, Knoppel EM, Fogelman AM. The effects of cholestyramine and mevinolin on the diurnal cycle of rat hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase. J Lipid Res 1982;23;1026-31.
    • (1982) J Lipid Res , vol.23 , pp. 1026-1031
    • Tanaka, R.D.1    Edwards, P.A.2    Lan, S.-F.3    Knoppel, E.M.4    Fogelman, A.M.5
  • 10
    • 0025870127 scopus 로고
    • Effects of probucol on blood cholesterol and basal and lovastatin-induced 3-hydroxy-3-methylgutaryl coenzyme A reductase activity in mice
    • Gebhard RL, Prigge WF, Andreini JP, Freeman ML. Effects of probucol on blood cholesterol and basal and lovastatin-induced 3-hydroxy-3-methylgutaryl coenzyme A reductase activity in mice. J Lab Clin Med 1991;117:299-304.
    • (1991) J Lab Clin Med , vol.117 , pp. 299-304
    • Gebhard, R.L.1    Prigge, W.F.2    Andreini, J.P.3    Freeman, M.L.4
  • 11
    • 0019983996 scopus 로고
    • The effect of mevinolin on serum cholesterol levels of rabbit with endogenous hypercholesterolemia
    • Kroon PA, Hand KM, Huff JW, Alberts AW. The effect of mevinolin on serum cholesterol levels of rabbit with endogenous hypercholesterolemia. Atherosclerosis 1982;44:41-8.
    • (1982) Atherosclerosis , vol.44 , pp. 41-48
    • Kroon, P.A.1    Hand, K.M.2    Huff, J.W.3    Alberts, A.W.4
  • 12
    • 0022549920 scopus 로고
    • A receptor mediated pathway for cholesterol homeostasis
    • Brown MS, Goldstein JL. A receptor mediated pathway for cholesterol homeostasis. Science 1986;232:34-7.
    • (1986) Science , vol.232 , pp. 34-37
    • Brown, M.S.1    Goldstein, J.L.2
  • 13
    • 0026354754 scopus 로고
    • Multifactorial etiology of hypercholesterolemia: Implications for prevention of coronary heart disease
    • Grundy SM. Multifactorial etiology of hypercholesterolemia: implications for prevention of coronary heart disease. Arterioscler Thromb 1991;11:1619-35.
    • (1991) Arterioscler Thromb , vol.11 , pp. 1619-1635
    • Grundy, S.M.1
  • 14
    • 0014440641 scopus 로고
    • Measurements of cholesterol turnover, synthesis and absorption in man, carried out by isotopic kinetic and sterol balance methods
    • Grundy SM, Ahrens Jr EH. Measurements of cholesterol turnover, synthesis and absorption in man, carried out by isotopic kinetic and sterol balance methods. J Lipid Res 1969;10:91-107.
    • (1969) J Lipid Res , vol.10 , pp. 91-107
    • Grundy, S.M.1    Ahrens E.H., Jr.2
  • 15
    • 0025291071 scopus 로고
    • Evidence for diurnal periodicity in human cholesterol biosynthesis
    • Jones PJH, Schoeller DA. Evidence for diurnal periodicity in human cholesterol biosynthesis. J Lipid Res 1990;31:667-73.
    • (1990) J Lipid Res , vol.31 , pp. 667-673
    • Jones, P.J.H.1    Schoeller, D.A.2
  • 16
    • 0023737126 scopus 로고
    • Serum lathosterol concentration is an indicator of whole-body cholesterol synthesis in humans
    • Kempen HJM, Glatz JFC, Leuven JAG, Vander Voort HA, Katan MB. Serum lathosterol concentration is an indicator of whole-body cholesterol synthesis in humans. J Lipid Res 1988;29:1149-55.
    • (1988) J Lipid Res , vol.29 , pp. 1149-1155
    • Kempen, H.J.M.1    Glatz, J.F.C.2    Leuven, J.A.G.3    Vander Voort, H.A.4    Katan, M.B.5
  • 18
    • 0029797661 scopus 로고    scopus 로고
    • Dietary cholesterol feeding suppresses human cholesterol synthesis measured by deuterium incorporation and urinary mevalonic acid levels
    • Jones PJH, Pappu AS, Hatcher L, Li ZC, Illingworth DR, Connor WE. Dietary cholesterol feeding suppresses human cholesterol synthesis measured by deuterium incorporation and urinary mevalonic acid levels. Arterioscler Thromb Vasc Biol 1996;16:1222-8.
    • (1996) Arterioscler Thromb Vasc Biol , vol.16 , pp. 1222-1228
    • Jones, P.J.H.1    Pappu, A.S.2    Hatcher, L.3    Li, Z.C.4    Illingworth, D.R.5    Connor, W.E.6
  • 19
    • 0024538210 scopus 로고
    • Increased urinary mevalonic acid excretion in patients with abetalipoproteinemia and homozygous hypobetalipoproteinemia
    • Illingworth DR, Pappu AS, Gregg RE. Increased urinary mevalonic acid excretion in patients with abetalipoproteinemia and homozygous hypobetalipoproteinemia. Atherosclerosis 1989;76:21-7.
    • (1989) Atherosclerosis , vol.76 , pp. 21-27
    • Illingworth, D.R.1    Pappu, A.S.2    Gregg, R.E.3
  • 21
    • 0026662723 scopus 로고
    • Comparative hypolipidemic effects of lovastatin and simvastatin in patients with heterozygous familial hypercholesterolemia
    • Illingworth DR, Bacon S, Pappu AS, Sexton GJ. Comparative hypolipidemic effects of lovastatin and simvastatin in patients with heterozygous familial hypercholesterolemia. Atherosclerosis 1992;96:53-64.
    • (1992) Atherosclerosis , vol.96 , pp. 53-64
    • Illingworth, D.R.1    Bacon, S.2    Pappu, A.S.3    Sexton, G.J.4
  • 22
    • 0012901920 scopus 로고
    • National Heart, Lung and Blood Institute. DHEW publication no. 75-628. Bethesda, Md: National Institutes of Health
    • Lipid Research Clinic Manual 1. National Heart, Lung and Blood Institute. DHEW publication no. 75-628. Bethesda, Md: National Institutes of Health, 1974:74.
    • (1974) Lipid Research Clinic Manual 1 , pp. 74
  • 23
    • 0018696344 scopus 로고
    • Determination of mevalonate in blood plasma in man and rat: Mevalonate tolerance tests in man
    • Popjak G, Boehm G, Parker TS, Edwards P, Fogelman AM. Determination of mevalonate in blood plasma in man and rat: mevalonate tolerance tests in man. J Lipid Res 1979;20:716-28.
    • (1979) J Lipid Res , vol.20 , pp. 716-728
    • Popjak, G.1    Boehm, G.2    Parker, T.S.3    Edwards, P.4    Fogelman, A.M.5
  • 24
    • 0024327354 scopus 로고
    • Reduction in plasma low-density lipoproteins and urinary mevalonic acid by lovastatin in patients with heterozygous familial hypercholesterolemia
    • Pappu AS, Illingworth DR, Bacon S. Reduction in plasma low-density lipoproteins and urinary mevalonic acid by lovastatin in patients with heterozygous familial hypercholesterolemia. Metabolism 1989;38:542-9.
    • (1989) Metabolism , vol.38 , pp. 542-549
    • Pappu, A.S.1    Illingworth, D.R.2    Bacon, S.3
  • 25
    • 0024347273 scopus 로고
    • Contrasting effects of lovastatin and cholestyramine on low-density lipoprotein cholesterol and 24-hour urinary mevalonate excretion in patients with heterozygous familial hypercholesterolemia
    • Pappu AS, Illingworth DR. Contrasting effects of lovastatin and cholestyramine on low-density lipoprotein cholesterol and 24-hour urinary mevalonate excretion in patients with heterozygous familial hypercholesterolemia. J Lab Clin Med 1989;114:554-62.
    • (1989) J Lab Clin Med , vol.114 , pp. 554-562
    • Pappu, A.S.1    Illingworth, D.R.2
  • 27
    • 0022348071 scopus 로고
    • Influence of mevinolin on low density lipoproteins in primary moderate hypercholesterolemia
    • Grundy SM, Vega GL. Influence of mevinolin on low density lipoproteins in primary moderate hypercholesterolemia. J Lipid Res 1985;26:1464-75.
    • (1985) J Lipid Res , vol.26 , pp. 1464-1475
    • Grundy, S.M.1    Vega, G.L.2
  • 28
    • 0023481283 scopus 로고
    • Suppression of apolipoprotein production during treatment of cholesteryl ester storage disease with lovastatin: Implications for apolipoprotein B synthesis
    • Ginsberg HN, Le NA, Short MP, Ramakrishnan R, Desnick RJ. Suppression of apolipoprotein production during treatment of cholesteryl ester storage disease with lovastatin: implications for apolipoprotein B synthesis. J Clin Invest 1987;80:1692-7.
    • (1987) J Clin Invest , vol.80 , pp. 1692-1697
    • Ginsberg, H.N.1    Le, N.A.2    Short, M.P.3    Ramakrishnan, R.4    Desnick, R.J.5
  • 29
    • 0026680805 scopus 로고
    • Effects of lovastatin therapy on low-density lipoprotein triglycerides metabolism in subjects with combined hyperlipidemia: Evidence for reduced assembly and secretion of triglyceride-rich lipoproteins
    • Arad Y, Ramakrishnan R, Ginsberg HN. Effects of lovastatin therapy on low-density lipoprotein triglycerides metabolism in subjects with combined hyperlipidemia: evidence for reduced assembly and secretion of triglyceride-rich lipoproteins. Metabolism 1992;41:487-93.
    • (1992) Metabolism , vol.41 , pp. 487-493
    • Arad, Y.1    Ramakrishnan, R.2    Ginsberg, H.N.3
  • 30
    • 0026088892 scopus 로고
    • Expanded clinical evaluation of lovastatin (EXCEL) study results. I. Efficacy in modifying plasma lipoproteins and adverse event profile in 8245 patients with moderate hypercholesterolemia
    • Bradford RH, Shear CL, Chremos AN, Dujovne C, Downton M, Franklin FA, et al. Expanded clinical evaluation of lovastatin (EXCEL) study results. I. Efficacy in modifying plasma lipoproteins and adverse event profile in 8245 patients with moderate hypercholesterolemia. Arch Intern Med 1991;151:43-9.
    • (1991) Arch Intern Med , vol.151 , pp. 43-49
    • Bradford, R.H.1    Shear, C.L.2    Chremos, A.N.3    Dujovne, C.4    Downton, M.5    Franklin, F.A.6
  • 31
    • 0021416308 scopus 로고
    • Inhibition of 3-hydroxy-3-methylglutaryl CoA reductase by mevinolin in familial hypercholesterolemia heterozygotes: Effects on cholesterol balance
    • Grundy SM, Bilheimer DW. Inhibition of 3-hydroxy-3-methylglutaryl CoA reductase by mevinolin in familial hypercholesterolemia heterozygotes: effects on cholesterol balance. Proc Natl Acad Sci U S A 1984;81:2538-42.
    • (1984) Proc Natl Acad Sci U S A , vol.81 , pp. 2538-2542
    • Grundy, S.M.1    Bilheimer, D.W.2
  • 34
    • 0141646834 scopus 로고
    • Appearance of crystalloid endoplasmic reticulum in compactin resistant Chinese hamster cells with 500-fold 3-hydroxy-3-methylglutaryl coenzyme A reductase
    • Chin D, Lusky KL, Anderson RGW, Faust R, Goldstein JL, Brown MS. Appearance of crystalloid endoplasmic reticulum in compactin resistant Chinese hamster cells with 500-fold 3-hydroxy-3-methylglutaryl coenzyme A reductase. Proc Natl Acad Sci U S A 1982;79:1185-9.
    • (1982) Proc Natl Acad Sci U S A , vol.79 , pp. 1185-1189
    • Chin, D.1    Lusky, K.L.2    Anderson, R.G.W.3    Faust, R.4    Goldstein, J.L.5    Brown, M.S.6
  • 35
    • 0342620065 scopus 로고
    • Lovastatin, an inhibitor of cholesterol synthesis, induces hydroxy methylglutaryl-coenzyme A reductase directly on membranes of expanded smooth endoplasmic reticulum in rat hepatocytes
    • Singer I, Scott IS, Kazazis DM, Huff JW. Lovastatin, an inhibitor of cholesterol synthesis, induces hydroxy methylglutaryl-coenzyme A reductase directly on membranes of expanded smooth endoplasmic reticulum in rat hepatocytes. Proc Natl Acad Sci U S A 1988;85:5264-8.
    • (1988) Proc Natl Acad Sci U S A , vol.85 , pp. 5264-5268
    • Singer, I.1    Scott, I.S.2    Kazazis, D.M.3    Huff, J.W.4
  • 36
    • 0025120211 scopus 로고
    • Regulation of mevalonate pathway
    • Goldstein JL, Brown MS. Regulation of mevalonate pathway. Nature 1990;343:425-30.
    • (1990) Nature , vol.343 , pp. 425-430
    • Goldstein, J.L.1    Brown, M.S.2
  • 37
    • 0029969302 scopus 로고    scopus 로고
    • Regulation of 3-hydroxy - 3-Methylglutaryl-coenzyme A reductase degradation by non-sterol mevalonate metabolite farnesol in vivo
    • Meigs TE, Roseman DS, Simoni RD. Regulation of 3-hydroxy - 3-methylglutaryl-coenzyme A reductase degradation by non-sterol mevalonate metabolite farnesol in vivo. J Biol Chem 1996;271:7916-22.
    • (1996) J Biol Chem , vol.271 , pp. 7916-7922
    • Meigs, T.E.1    Roseman, D.S.2    Simoni, R.D.3


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