Growth response to increasing doses of microencapsulated vitamin b12 and related changes in tissue vitamin b12 concentrations in cobalt-de cient lambs

New Zealand Veterinary Journal

Volumn 51, Issue 2, 2003, Pages 89-92

  Grace, N D ^a   Knowles, S O ^a   Sinclair, G R ^b  

^a AGRESEARCH GRASSLANDS   (New Zealand)

^b Gore Veterinary Services   (New Zealand)

Author keywords

Cobalt deficiency; Growth; Lambs; Liver; Serum; Vitamin B12

Indexed keywords

COBALT; CYANOCOBALAMIN; SMARTSHOT;

ARTICLE; BLOOD ANALYSIS; BODY WEIGHT; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; FEMALE; GROWTH RATE; HERD; LAMB; LIVER BIOPSY; LIVER LEVEL; MALE; MICROENCAPSULATION; NEW ZEALAND; NONHUMAN; PASTURE; PROBABILITY; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION; WEIGHT REDUCTION;

ANIMALIA; OVIS ARIES; STAPHYLOCOCCUS PHAGE 187;

EID: 0037387792     PISSN: 00480169     EISSN: 11760710     Source Type: Journal    
DOI: 10.1080/00480169.2003.36345     Document Type: Article

References (22)

1. Andrews ED. Responses of cobalt deficient lambs to cobalt and to vitamin B12. New Zealand Journal of Science and Technology 35A, 483–8, 1954
2. Andrews ED, Isaacs CE, Findlay RJ. Response of cobalt deficient lambs to cobaltic oxide pellets. New Zealand Journal 6, 140–6, 1958
3. Andrews ED, Grant AB, Stephenson BJ. Weight responses of sheep to cobalt and selenium in relation to vitamin B12 and selenium concentrations in liver and kidney. New Zealand Journal of Agricultural Research 7, 17–27, 1963
4. Andrews ED, Stephenson BJ, Isaacs CE, Register RH. The effects of large doses of soluble and insoluble forms of cobalt given at monthly intervals on cobalt deficiency disease in lambs. New Zealand Veterinary Journal 14, 191–6, 1966
5. Clark RG, Wright DF, Millar KR, Rowland JD. Reference curves to diagnose cobalt deficiency in sheep using liver and serum vitamin B12 levels. New Zealand Veterinary Journal 37, 7–11, 1989
6. Dick AT. Aspiration biopsy of the liver in sheep. Australian Veterinary Journal 20, 298–303, 1944
7. Gawthorne JM. The excretion of methylmalonic and formiminoglutamic acids during its induction and remission of vitamin B12 deficiency in sheep. Australian Journal of Biological Sciences 21, 789–94, 1968
8. Grace ND. Cobalt (Co). In:Managing Trace Element Deficiencies. Pp 25–34. AgResearch, Palmerston North, 1994
9. Grace ND, Lewis DL. An evaluation of the efficacy of injectable microencapsulated vitamin B12 in increasing and maintaining the serum and liver vitamin B12 concentrations of lambs. New Zealand Veterinary Journal 47, 3–11, 1999
10. Grace ND, Sinclair GR. Growth response in lambs injected with a long acting microencapsulated vitamin B12. New Zealand Veterinary Journal 47, 213–4, 1999
11. Jago J, Wilson PE, Lee BM. Determination of sub-microgram amounts of cobalt in plant and animal tissues by extraction and atomic absorption spectroscopy. The Analyst 96, 349–53, 1971
12. Judson GJ, Babidge PJ. Vitamin B12 injection for preventing cobalt deficiency in lambs. Australian Veterinary Journal 80, 777–8, 2002
13. Judson GJ, Caple IW, Langlands JP, Peter DW. Mineral nutrition of grazing ruminants in Southern Australia. In:Wheeler JL, Pearson CJ, Robards GE (eds). Temperate Pastures:Their Production, Use and Management. Pp 377–85. Australian Wool Corporation Technical Publication, Melbourne, 1987
14. Kennedy DG, O’Harte FPM, Blanchflower WJ, Rice DA. Sequential changes in propionate metabolism during the development of cobalt/vitamin B12 deficiency in sheep. Biological Trace Element Research 28, 233–41, 1991
15. Kennedy DG, Blanchflower JW Scott JM, Weir DG, Molloy AM, Kennedy S, Young PB. Cobalt-Vitamin B12 deficiency decreases methionine synthase activity and phospholipids methylation to sheep. Journal of Nutrition 122, 1384–90, 1992
16. Millar KR, Albyt AT. A comparison of vitamin B12 levels in the liver and serum of sheep receiving treatments to correct cobalt deficiency. New Zealand Veterinary Journal 32, 105–8, 1984
17. O’Harte FPM, Kennedy DG, Blanchflower WJ, Rice DA. Methylmalonic acid in the diagnosis of cobalt deficiency in barley-fed lambs. British Journal of Nutrition 62, 729–38, 1989
18. Price J, Barrie SG, Ueno S. Unusual behaviour of a vitamin B12-binder, Transcobalamin1, in cattle plasma. Proceedings of the Nutrition Society 51, 23A, 1992
19. Rice DA, McLoughlin M, Blanchflower WJ, Goodall EA, McMurray CH. Methylmalonic acid as an indicator of vitamin B12 deficiency in grazing sheep. Veterinary Record 121, 472–3, 1987
20. Rice DA, McLoughlin M, Blanchflower WJ, McMurray CH, Goodall EA. Sequential changes in plasma methylmalonic acid and vitamin B12 in sheep eating cobalt deficient grass. Biological Trace Element Research 22, 153–64, 1989
21. Smith RM, Marston HR. Production, absorption and excretion of vitamin B12 in sheep. British Journal of Nutrition 24, 857–77, 1970
22. Stebbings RStJ, Lewis G. Cobalt deficiency and urinary formiminoglutamic acid in lambs. British Veterinary Journal 142, 270–4, 1986