1H NMR spectroscopy and GC-MS analysis of α-chloralose. Application to two poisoning cases

Journal of Analytical Toxicology

Volumn 27, Issue 3, 2003, Pages 156-161

  Savin, Sandrine ^a   Cartigny, Bernard ^a   Azaroual, Nathalie ^b   Humbert, Luc ^a   Imbenotte, Michel ^c   Tsouria, Djamel ^d   Vermeersch, Gaston ^b   Lhermitte, Michel ^a,c  

^a LILLE UNIVERSITY HOSPITAL   (France)

^b Université Lille Nord de France   (France)

^c Laboratoire de Physique   (France)

^d Hopital Victor Provo   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GLUCURONIDASE; CHLORALOSE; RODENTICIDE; ATROPINE; MUSCARINIC RECEPTOR BLOCKING AGENT;

ACETYLATION; ADULT; ANAMNESIS; ARTICLE; CASE REPORT; COMA; GAS CHROMATOGRAPHY; HUMAN; HYPERSALIVATION; INTOXICATION; MALE; MASS SPECTROMETRY; MYOCLONUS; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE ANALYSIS; SENSITIVITY AND SPECIFICITY; URINALYSIS; MASS FRAGMENTOGRAPHY; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SUICIDE ATTEMPT; TREATMENT OUTCOME; URINE;

AVES;

ADULT; ATROPINE; CHLORALOSE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE AGED; MUSCARINIC ANTAGONISTS; OVERDOSE; RODENTICIDES; SUICIDE, ATTEMPTED; TREATMENT OUTCOME;

EID: 0037387590     PISSN: 01464760     EISSN: None     Source Type: Journal    
DOI: 10.1093/jat/27.3.156     Document Type: Article

References (21)

1. S. Forsén, B. Lindberg, and B.-G. Silvander. Trichloroethylidene derivates of D-glucose. Acta Chem. Scand. 19: 359-369 (1965).
2. P.M. Brown, P.J. Bunyan, and P.I. Stanley. The investigation and pattern of occurrence of animal poisoning resulting from the misuse of agricultural chemicals. J. Forensic Sci. Soc. 17: 211-221 (1977).
3. S. Clément, F.P. Savy, D. Dumont, G. Lachâtre, E. Frogé, and C. Piva. Chloralose. Constancy of voluntary poisoning in rural areas. About 12 cases (in French). J. Med. Leg. Droit Med. 35: 105-109 (1992).
4. A. Turcant, P. Harry, L. Tellier, A. Lebouil, and P. Allain. Analytical diagnosis of intoxication by alpha-chloralose: interest and limitation. Toxicorama 9: 212-218 (1997).
5. H.M. Thomas, D. Simpson, and L.F. Prescott. The toxic effects of alpha-chloralose. Hum. Toxicol. 7: 285-287 (1988).
6. P. Kintz, S. Doray, V. Cirimele, and B. Ludes. Testing for alpha-chloralose by headspace-GC/MS. A case report. Forensic Sci. Int. 104: 59-63 (1999).
7. F. Flesch, P. Kintz, P. Reydel, C. Tournoud, A. Jaeger, and B. Ludes. Chloralose: 49 clincal cases over a 30-year period (in French). Ann. Toxicol. Anal. 12: 157-158 (2000).
8. C. Richelme, G. Duval, J. Gérard, J.-C. Corbin, and C. Chuet. Voluntary chloralose poisoning. Cah. Anesthesiol. 33: 589-592 (1985).
9. A. Shita, A. Cornil, and M. Ectors. Clinical and electroencephalographic aspects of a severe case of alpha-chloralose poisoning (in French). Acta Clin. Belg. 36: 20-24 (1981).
10. C. Bruhat, A. Turcant, P. Harry, A. Lebouil, and P. Allain. Chloralose: acute poisonings with toxicological analysis (in French). Ann. Toxicol. Anal. 12: 158 (2000).
11. C. Hamouda, M. Amamou, S. Jédidi, A. Hédhili, N. BenSalah, and H. Thabet. A graded classification of acute chloralose poisoning based on 509 cases. Presse Med. 30: 1055-1058 (2001).
12. P. Kintz, F. Flesch, V. Cirimele, P. Sauder, and B. Ludes. Chloralose: analytical and forensic aspects (in French). Ann. Toxicol. Anal. 12: 158-159 (2000).
13. A. Tracqui, S. Doray, and B. Ludes. Determination of free and conjugated α-chloralose in biological samples by HPLC/ionspray-MS. Application to a fatality involving α-chloralose. Toxicorama 11: 125-132 (1999).
14. S. Maschke, N. Azaroual, M. Imbenotte, G. Vermeersch, F. Leclerc, and M. Lhermitte. Salicylate poisoning: two-dimensional J-resolved NMR urinalysis. NMR Biomed. 8: 19-24 (1995).
15. 1H NMR spectroscopy of paraquat in urine from acutely poisoned patients. Comparison with second-derivative spectrosccopy method. J. Anal. Toxicol. 23: 586-590 (1999).
16. E.M. Komoroski, R.A. Komoroski, J.L. Valentine, J.M. Pearce, and G.L. Kearns. The use of nuclear magnetic resonance spectroscopy in the detection of drug intoxication. J. Anal. Toxicol. 24: 180-187 (2000).
17. K. Pfleger, H.H. Maurer, and A. Weber. Mass Spectral and GC Data of Drugs, Poisons, Pesticides, Pollutants and Their Metabolites, 2nd ed. VCH, New York, NY, 1992, p 1849.
18. P. Kintz, C. Jamey, and P. Mangin. Trichloroethanol is not a metabolite of alpha chloralose. Int. J. Leg. Med. 108: 191-193 (1996).
19. G. Gras, C. Pellissier, and F. Fauran. Toxicologic analysis of chloralose. Application to three cases of acute intoxication (in French). Eur. J. Toxicol. Environ. Hyg. 8: 371-377 (1975).
20. A. Wahl, N. Azaroual, M. Imbenotte, D. Mathieu, G. Forzy, B. Cartigny, G. Vermeersch, and M. Lhermitte. Poisoning with methanol and ethylene glycol: 1H NMR spectroscopy as an effective clinical tool for diagnosis and quantification. Toxicology 128: 73-81 (1998).
21. B. Cartigny, N. Azaroual, M. Imbenotte, N. Houdret, H. Malandain, G. Vermeersch, and M. Lhermitte. Determination of formic and glycolic acids in serum by 1H NMR spectroscopy: a new method applicable to delayed diagnosis of methanol and ethylene glycol intoxications. Ann. Toxicol. Anal. 13: 80-87 (2001).