mRNA expression pattern of multiple members of connexin gene family in normal and abnormal fetal gonads in mouse

Indian Journal of Physiology and Pharmacology

Volumn 47, Issue 2, 2003, Pages 147-156

  Juneja, Subhash C ^a,b  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Connexin43 knockout; Connexins; Fetal gonads; Mouse; MRNA expression

Indexed keywords

CONNEXIN 26; CONNEXIN 30; CONNEXIN 31; CONNEXIN 32; CONNEXIN 37; CONNEXIN 40; CONNEXIN 43; CONNEXIN 45; CONNEXIN 46; CONNEXIN 50; GAP JUNCTION PROTEIN; MESSENGER RNA; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FETUS; GAP JUNCTION; GENOTYPE; GONAD DEVELOPMENT; GONADAL DISEASE; HETEROZYGOTE; INFERTILITY; KNOCKOUT MOUSE; MOUSE; NONHUMAN; OVARY; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TESTIS;

ANIMALS; CONNEXINS; FEMALE; FETUS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GONADS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PREGNANCY; RNA, MESSENGER;

EID: 0037387513     PISSN: 00195499     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Bruzzone R, White TW, Goodenough DA. The cellular Internet: on-line with connexins. Bio Essays 1996(a); 18: 709.
2. Bruzzone R, White TW, Paul DL. Connections with connexins: the molecular basis of direct intercellular signaling. Eur J Biochem 1996; 238: 1.
3. Dahl E, Manthey D, Chen Y, Schwartz HJ, Chang YS, Lalley PA, Nicholson BJ, Willecke K. Molecular cloning and functional expression of mouse connexin-30, a gap junction gene highly expressed in adult brain and skin. J Biol Chem 1996; 271: 17903.
4. Condorelli DF, Parenti R, Spinella F, Trovato Salinaro A, Belluardo N, Cardile V, Cicirata F. Cloning of a new gap junction gene (Cx36) highly expressed in mammalian brain neurons. Eur J Neurosci 1998; 10: 1202.
5. Manthey D, Bukauskas F, Lee CG, Kosak CA, Willecke K. Molecular cloning and functional expression of the mouse gap junction gene connexin-57 in human HeLa cells. J Biol Chem 1999; 274: 14716.
6. Sohl G, Theis M, Hallas G, Brambach S, Dahl E, Kidder G, Willecke K. A new alternatively spliced transcript of the mouse connexin 32 gene is expressed in embryonic stem cells, oocytes, and liver. Exp Cell Res 2001; 266: 177.
7. Teubner B, Odermatt B, Guldenagel M, Sohl G, Degen J, Bukauskas F, Kronengold J, Verselis VK, Jung YT, Kozak CA, Schilling K, Willecke K. Functional expression of the new gap junction gene connexin 47 transcribed in mouse brain and spinal cord neurons. J Neurosci 2001; 21: 1117.
8. Sáez JC, Connor JA, Spray DC, Bennett MV. Hepatocyte gap junctions are permeable to the second messenger, inositol 1,4,5-trisphosphate, and to calcium ions. Proc Natl Acad Sci USA 1989; 86: 2708.
9. Zhang JT, Nicholson BJ. Sequence and tissue distribution of a second protein of hepatic gap junctions, Cx26, as deduced from its cDNA. J Cell Biol 1989; 109: 3391.
10. Haefliger JA, Bruzzone R, Jenkins NA, Gilbert DJ, Copeland NG, Paul DL. Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping. J Biol Chem 1992; 267: 2057.
11. Kadle R, Zhang JT, Nicholson BJ. Tissue-specific distribution of differentially phosphorylated forms of Cx43. Mol Cell Biol 1991; 11: 363.
12. Risley MS, Tan IP, Roy C, Sáez JC. Cell-, age- and stage-dependent distribution of connexin 43 gap junctions in testes. J Cell Sci 1992; 103: 81.
13. Pérez-Armendariz EM, Romano MC, Luna J, Miranda C, Bennett MVL, Moreno AP. Characterization of gap junctions between pairs of Leydig cells from mouse testis. Am J Physiol 1994; 267: C570.
14. Lablack A, Bourdon V, Defamie N, Batias C, Mesnil M, Fenichel P, Pointis G, Segretain D. Ultrastructural and biochemical evidence for gap junction and connexin 43 expression in a clonal Sertoli cell line: a potential model in the study of junctional complex formation. Cell Tissue Res 1998; 294: 279.
15. Pérez-Armendariz EM, Lamoyi E, Mason JI, Cisneros-Armas D, Luu-The V, Moreno JF. Developmental regulation of connexin 43 expression in fetal mouse testicular cells. Anat Rec 2001; 264: 237.
16. Valdimarsson G, De Sousa PA, Kidder GM. Coexpression of gap junction proteins in the cumulusoocyte complex. Mol Reprod Dev 1993; 36: 7.
17. Okuma A, Kuraoka A, Iida H, Inai T, Wasano K, Shibata Y. Colocalization of connexin 43 and connexin 45 but absence of connexin 40 in granulosa cell gap junctions of rat ovary. J Reprod Fertil 1996; 107: 255.
18. Li R, Mather JP. Lindane, an inhibitor of gap junction formation, abolishes oocyte directed follicle organizing activity in vitro. Endocrinology 1997; 138: 4477.
19. Simon AM, Goodenough DA, Li E, Paul DL. Female infertility in mice lacking connexin 37. Nature 1997; 385: 525.
20. Wright CS, Becker DL, Lin JS, Warner AE, Hardy K. State-specific and differential expression of gap junctions in the mouse ovary: connexin-specific roles in follicular regulation. Reproduction 2001; 121: 77.
21. Nelles E, Butzler C, Jung D, Temme A, Gabriel HD, Dahl U, Traub O, Stumpel F, Jungermann K, Zielasek J, Toyka KV, Dermietzel R, Willecke K. Defective propagation of signals generated by sympathetic nerve stimulation in the liver of connexin 32-deficient mice. Proc Natl Acad Sci USA 1996; 93: 9565.
22. Sommersberg B, Bulling A, Salzer U, Fröhlich U, Garfield RE, Amsterdam A, Mayerhofer A. Biol Reprod 2000; 63: 1661.
23. Reaume A, De Sousa PA, Kulkarni S, Langille BL, Zhu D, Davies TC, Juneja SC, Kidder GM, Rossant J. Cardiac malformation in neonatal mice lacking connexin 43. Science 1995; 267: 1831.
24. Juneja SC, Barr KJ, Enders GC, Kidder GM. Defects in the germ line and gonads of mice lacking connexin 43. Biol Reprod 1999; 60: 1263.
25. De Sousa PA, Valdimarsson G, Nicholson BJ, Kidder GM. Connexin trafficking and the control of gap junction assembly in mouse preimplantation embryos. Development 1993; 117: 1355.
26. Nishi M, Kumar NM, Gilula NB. Developmental regulation of gap junction gene expression during mouse embryonic development. Dev Biol 1991; 146: 117.
27. Hennemann H, Dahl E, White J, Schwarz HJ, Lalley PA, Nicholson BJ, Willecke K. Two gap junction genes, connexin 31.1 and 30.3, are closely linked on mouse chromosome 4 and preferentially expressed in skin. J Biol Chem 1992; 267: 17225.
28. Hennemann H, Schwarz HJ, Willecke K. Characterization of gap junction genes expressed in F9 embryonic carcinoma cells: molecular cloning of mouse connexin 31 and -45 cDNAs. Eur J Cell Biol 1992; 57: 51.
29. Hennemann H, Suchyna T, Lichtenberg-Frate J, Jungbluth S, Dahl E, Schwarz J, Nicholson BJ, Willecke K. Molecular cloning and functional expression of mouse connexin 40, a second gap junction gene preferentially expressed in lung. J Cell Biol 1992; 117: 1299.
30. De Sousa PA, Juneja SC, Caveney S, Houghton FD, Davies TC, Reaume AG, Rossant J, Kidder GM. Normal development of preimplantation mouse embryos deficient in gap junctional coupling. J Cell Sci 1997; 110: 1751.
31. Ebihara L, Paul DL, Takemoto LJ, Swenson KI, Goodenough DA. Connexin 46, a novel lens gap junction protein, induces voltage-gated currents in nonjunctional plasma membrane of Xenopus oocytes. J Cell Biol 1991; 115: 1077.
32. White TW, Bruzzone R, Goodenough DA, Paul DL. Mouse Cx50, a functional member of the connexin family of gap junction proteins, is the lens fiber protein MP70. Mol Biol Cell 1992; 3: 711.
33. Melton CM, Zaunbrecher GM, Yoshizaki G, Patiño R, Whisnant S, Rendon A, Lee VH. Expression of connexin 43 mRNA and protein in developing follicles of prepubertal porcine ovaries. Comp Biochem Physiol 2001; 130: 43.
34. Nagano T, Suzuki F. Freeze-fracture observations on the intercellular junctions of Sertoli cells and of Leydig cells in the human testis. Cell Tissue Res 1976; 166: 37.
35. Bigliardi E, Vegni-Talluri M. Gap junctions between Sertoli cells in the infertile human testis. Fertil Steril 1977; 28: 755.
36. Schleiermacher E. Ultrastructural changes of the intercellular relationship in impaired human spermatogenesis. Hum Genet 1980; 54: 391.
37. Batias C, Defamie N, Lablack A, Thepot D, Fenichel P, Segretain D, Points G. Modified expression of testicular gap-junction connexin 43 during normal spermatogenic cycle and in altered spermatogenesis. Cell Tissue Res 1999; 298: 113.